Patents by Inventor Grigory Veinberg

Grigory Veinberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • N-carbamoylmethyl-4-(R)-phenyl-2-pyrrolidinone, method of its preparation and pharmaceutical use
    Patent number: 9382203
    Abstract: The invention relates to the R-enantiomer of N-carbamoylmethyl-4-phenyl-2-pyrrolidinone (R-Carphedon) of pharmacological value. The method of its preparation includes the N-alkylation of 4(R)-phenyl-2-pyrrolidinone with ethyl bromoacetate in the presence of a strong base and the treatment of intermediate N-ethoxycarbonylmethyl-4(R)-phenyl-2-pyrrolidinone with ammonia.
    Type: Grant
    Filed: April 16, 2015
    Date of Patent: July 5, 2016
    Assignee: JOINT STOCK COMPANY (JSC) “OLAINFARM”
    Inventors: Grigory Veinberg, Maksim Vorona, Liga Zvejniece, Aleksandrs Chernobrovijs, Ivars Kalvinsh, Ligita Karina, Maija Dambrova
  • N-Carbamoylmethy1-4-(R)-phenyl-2-pyrrolidinone, method of its preparation and pharmaceutical use
    Patent number: 9102615
    Abstract: The invention relates to the R-enantiomer of N-carbamoylmethyl-4-phenyl-2-pyrrolidinone (R-Carphedon) of pharmacological value. The method of its preparation includes the N-alkylation of 4(R)-phenyl-2-pyrrolidinone with ethyl bromoacetate in the presence of a strong base and the treatment of intermediate N-ethoxycarbonylmethyl-4(R)-phenyl-2-pyrrolidinone with ammonia.
    Type: Grant
    Filed: March 15, 2007
    Date of Patent: August 11, 2015
    Assignee: Joint Stock Company (JSC) “OLAINFARM”
    Inventors: Grigory Veinberg, Maksim Vorona, Liga Zvejniece, Aleksandrs Chernobrovijs, Ivars Kalvinsh, Ligita Karina, Maija Dambrova
  • N-Carbamoylmethyl-4-(R)-Phenyl-2-Pyrrolidinone, Method of its Preparation and Pharmaceutical Use
    Publication number: 20150216846
    Abstract: The invention relates to the R-enantiomer of N-carbamoylmethyl-4-phenyl-2-pyrrolidinone (R-Carphedon) of pharmacological value. The method of its preparation includes the N-alkylation of 4(R)-phenyl-2-pyrrolidinone with ethyl bromoacetate in the presence of a strong base and the treatment of intermediate N-ethoxycarbonylmethyl-4(R)-phenyl-2-pyrrolidinone with ammonia.
    Type: Application
    Filed: April 16, 2015
    Publication date: August 6, 2015
    Inventors: Grigory Veinberg, Maksim Vorona, Liga Zvejniece, Aleksandrs Chernobrovijs, Ivars Kalvinsh, Ligita Karina, Maija Dambrova
  • Regeneration of 2,2?-cyclopropylidene-bis (oxazolines)
    Patent number: 8846944
    Abstract: The present invention provides a method for regeneration of chiral 2,2?-cyclopropylidene-bis(oxazolines), such as (3&R,3?aR,8aS,8?aS)-2,2?-cyclopropylidenebis-[3a,8a]-dihydro-8H-indeno-[1,2-d]-oxazole and (45,4?5,5R,5?R)-2,2?-cyclopropylidenebis-4,5-diphenyldihydro-4,5-oxazole, used as a part of complex catalysts for e.g. stereoselective addition reactions, from the reaction mixtures, by selective sorption of 2,2?-cyclopropylidene-bis(oxazolines) on a sorbent, such as silica gel, isolation of the sorbent from reaction mixture, desorption of 2,2?-cyclopropylidene-bis(oxazolines) from the sorbent with suitable organic solvent and final recovery of 2,2?-cyclopropylidene-bis(oxazolines) from the organic solvent used for desorption process. Catalytic quality of recovered compounds does not differ from those in freshly prepared catalysts.
    Type: Grant
    Filed: November 30, 2009
    Date of Patent: September 30, 2014
    Assignee: Latvian Institute of Organic Synthesis
    Inventors: Ivars Kalvinsh, Antons Lebedevs, Aleksandrs Chernobrovijs, Grigory Veinberg, Maksims Vorona, Agnija Ievina
  • REGENERATION OF 2,2'-CYCLOPROPYLIDENE-BIS (OXAZOLINES)
    Publication number: 20110263864
    Abstract: The present invention provides a method for regeneration of chiral 2,2?-cyclopropylidene-bis(oxazolines), such as (3&R, 3?aR,8aS,8?aS)-2,2?-cyclopropylidenebis-[3a,8a]-dihydro-8H-indeno-[1,2-d]-oxazole and (45,4?5,5R,5?R)-2,2?-cyclopropy-lidenebis-4,5-diphenyldihydro-4,5-oxazole, used as a part of complex catalysts for e.g. stereoselective addition reactions, from the reaction mixtures, by selective sorption of 2,2?-cyclopropylidene-bis(oxazolines) on a sorbent, such as silica gel, isolation of the sorbent from reaction mixture, desorption of 2,2?-cyclopropylidene-bis(oxazolines) from the sorbent with suitable organic solvent and final recovery of 2,2?-cyclopropylidene-bis(oxazolines) from the organic solvent used for desorption process. Catalytic quality of recovered compounds does not differ from those in freshly prepared catalysts.
    Type: Application
    Filed: November 30, 2009
    Publication date: October 27, 2011
    Inventors: Ivars Kalvinsh, Antons Lebedevs, Aleksandrs Chernobrovijs, Grigory Veinberg, Maksims Vorona, Agnija Levina
  • N-Carbamoylmethyl-4-(R)-Phenyl-2-Pyrrolidinone, Method of its Preparation and Pharmaceutical Use
    Publication number: 20100022784
    Abstract: The invention relates to the R-enantiomer of N-carbamoylmethyl-4-phenyl-2-pyrrolidinone (R-Carphedon) of pharmacological value. The method of its preparation includes the N-alkylation of 4(R)-phenyl-2-pyrrolidinone with ethyl bromoacetate in the presence of a strong base and the treatment of intermediate N-ethoxycarbonylmethyl-4(R)-phenyl-2-pyrrolidinone with ammonia.
    Type: Application
    Filed: March 15, 2007
    Publication date: January 28, 2010
    Applicant: Joint Stock Company "Olainfarm"
    Inventors: Grigory Veinberg, Maksim Vorona, Aleksandrs Chernobrovijs, Ivars Kalvinsh, Ligita Karina, Maija Dambrova