Abstract: Wound closure apparatus is provided having a force-transmitting surface operable to be placed in a proximal, external, wound-closing position on a patient, together with a force-exerting assembly operable to exert a wound-closing pressure against the patient's tissue. The force-transmitting surface is preferably three-dimensionally asymmetric to generate different forces along the length of the surface. The apparatus is especially designed for the closure of wounds attendant to endovascular interventions, e.g., a femoral artery puncture wound. The apparatus is positioned and operated so as to partially close the patient's artery upstream of the arteriotomy. The apparatus and methods hereof may also be used for the closure of wounds created during venous intervention procedures. A smaller wound closure apparatus is provided for the closure of brachial and radial wounds, and has a wrist or arm strap for securing the apparatus onto the wrist or bicep region of a patient.

Abstract: Wound closure apparatus is provided having a force-transmitting surface operable to be placed in a proximal, external, wound-closing position on a patient, together with a force-exerting assembly operable to exert a wound-closing pressure against the patient's tissue. The force-transmitting surface is preferably three-dimensionally asymmetric to generate different forces along the length of the surface. The apparatus is especially designed for the closure of wounds attendant to endovascular interventions, e.g., a femoral artery puncture wound. The apparatus is positioned and operated so as to partially close the patient's artery upstream of the arteriotomy. The apparatus and methods hereof may also be used for the closure of wounds created during venous intervention procedures. A smaller wound closure apparatus is provided for the closure of brachial and radial wounds, and has a wrist or arm strap for securing the apparatus onto the wrist or bicep region of a patient.

Abstract: Wound closure apparatus is provided including a body having an elongated, lowermost force-transmitting surface operable to be placed in a proximal, external, wound-closing position on a patient, together with a force-exerting assembly coupled with the body and operable to exert a downwardly directed force serving to generate wound-closing pressure against the patient's tissue. The force-transmitting surface is preferably three-dimensionally asymmetric so that forces of different magnitude are exerted at different locations along the length of the surface. The apparatus is especially designed for the closure of wounds attendant to endovascular interventions, e.g., a femoral artery puncture wound incident to percutaneous cardiac intervention (PCI), and is capable of quickly effecting wound closure with a time-to-ambulation (TTA) of approximately 60 minutes, and with a very low complication rate.

Abstract: Wound closure apparatus is provided including a body having an elongated, lowermost force-transmitting surface operable to be placed in a proximal, external, wound-closing position on a patient, together with a force-exerting assembly coupled with the body and operable to exert a downwardly directed force serving to generate wound-closing pressure against the patient's tissue. The force-transmitting surface is preferably three-dimensionally asymmetric so that forces of different magnitude are exerted at different locations along the length of the surface. The apparatus is especially designed for the closure of wounds attendant to endovascular interventions, e.g., a femoral artery puncture wound incident to percutaneous cardiac intervention (PCI), and is capable of quickly effecting wound closure with a time-to-ambulation (TTA) of approximately 60 minutes, and with a very low complication rate.

Abstract: Wound closure apparatus is provided including a body having an elongated, lowermost force-transmitting surface operable to be placed in a proximal, external, wound-closing position on a patient, together with a force-exerting assembly coupled with the body and operable to exert a downwardly directed force serving to generate wound-closing pressure against the patient's tissue. The force-transmitting surface is preferably three-dimensionally asymmetric so that forces of different magnitude are exerted at different locations along the length of the surface. The apparatus is especially designed for the closure of wounds attendant to endovascular interventions, e.g., a femoral artery puncture wound incident to percutaneous cardiac intervention (PCI), and is capable of quickly effecting wound closure with a time-to-ambulation (TTA) of approximately 60 minutes, and with a very low complication rate.

Abstract: Wound closure apparatus is provided including a body having an elongated, lowermost force-transmitting surface operable to be placed in a proximal, external, wound-closing position on a patient, together with a force-exerting assembly coupled with the body and operable to exert a downwardly directed force serving to generate wound-closing pressure against the patient's tissue. The force-transmitting surface is preferably three-dimensionally asymmetric so that forces of different magnitude are exerted at different locations along the length of the surface. The apparatus is especially designed for the closure of wounds attendant to endovascular interventions, e.g., a femoral artery puncture wound incident to percutaneous cardiac intervention (PCI), and is capable of quickly effecting wound closure with a time-to-ambulation (TTA) of approximately 60 minutes, and with a very low complication rate.

Abstract: Wound closure apparatus is provided including a body having an elongated, lowermost force-transmitting surface operable to be placed in a proximal, external, wound-closing position on a patient, together with a force-exerting assembly coupled with the body and operable to exert a downwardly directed force serving to generate wound-closing pressure against the patient's tissue. The force-transmitting surface is preferably three-dimensionally asymmetric so that forces of different magnitude are exerted at different locations along the length of the surface. The apparatus is especially designed for the closure of wounds attendant to endovascular interventions, e.g., a femoral artery puncture wound incident to percutaneous cardiac intervention (PCI), and is capable of quickly effecting wound closure with a time-to-ambulation (TTA) of approximately 60 minutes, and with a very low complication rate.

Abstract: A wound sealing system and method for closing a vascular access site. The method invisions suturing a single continuous Z-stitch into a skin area around a wound and wound tract while the catheter remains within the vessel; covering the wound and suture holes with a hemostatic powder; tightening and knotting the ends of the suture together in an X configuration, applying finger pressure against the hemostatic powder as the catheter is removed; and twisting the suture ends together to tension the Z-stitch, pulling the skin area into inversion. The wound sealing system includes a powder containment device (PCD) which surrounds wound and catheter and a suture twisting member configured with the PCD to tension the Z-stitch closing the wound and arresting blood flow. The hole in the PCD holds a quantity of the hemostatic agent sufficient to cover the wound and suture holes.

Abstract: A method of reducing infections associated with vascular access procedures. A powder containment device (PCD) is preferably adhesively attached to a skin area, the PCD having a hole formed centrally therethrough adapted to completely surround the catheter wound site. The open cavity formed by the PCD being attached to the skin is filled with a hemostatic agent of a salt ferrate and an insoluble cation exchange material. The salt ferrate combines with blood to form a trivalent Fe+++ ion promoting blood clotting and producing oxygen at the wound site for bacteria reduction. The cation exchange material also forms a protective cover over the wound site as the trivalent Fe+++ ion is formed. Semi-occlusive pressure is applied against the hemostatic agent for a time sufficient to arrest blood flow from the wound site right after inserting or removing the catheter. The PCD and hemostatic agent are then covered with an adhesive dressing.

Abstract: A method of reducing infections associated with vascular access procedures. A powder containment device (PCD) is preferably adhesively attached to a skin area, the PCD having a hole formed centrally therethrough adapted to completely surround the catheter wound site. The open cavity formed by the PCD being attached to the skin is filled with a hemostatic agent of a salt ferrate and an insoluble cation exchange material. The salt ferrate combines with blood to form a trivalent Fe+++ ion promoting blood clotting and producing oxygen at the wound site for bacteria reduction. The cation exchange material also forms a protective cover over the wound site as the trivalent Fe+++ ion is formed. Semi-occlusive pressure is applied against the hemostatic agent for a time sufficient to arrest blood flow from the wound site right after inserting or removing the catheter. The PCD and hemostatic agent are then covered with an adhesive dressing.

Abstract: A cosmeceutically acceptable formulation as a wound dressing including red palm oil and a triglyceride, preferably fish oil, preferably derived from salmon. Another aspect of this disclosure is providing a mixture of red palm oil and very long chain (>C>18) omega 3 and 6 fatty acids. The formulation may also include one or more of the following: coconut oil and shea butter for anti-inflammatory activity and antimicrobial efficacy, fish collagen, an acidic preservative, a cationic surfactant, and various vitamins.

Abstract: A process and apparatus for increasing biological activity in waste treatment ponds and lagoons. In this process a floating fluid circulator having an annular space between nested frusto-conical surfaces is operated in a pond or lagoon. An aerator within the scope of the floating fluid circulator is provided. That aerator includes an upper float chassis having a frusto-conical configuration, a sectional diverter arranged in a lower portion of the upper float chassis, the sectional aerator having a lower diverter portion and motor driven means mounted on the upper float chassis connected to a rotatable impeller.

Abstract: The present invention is directed to transdermal compositions and the uses thereof. These compositions include at least one of the following components: a C1-C6 dialkyl, C12-C30 dialkyl quaternary ammonium salt, a C12-C30 fatty acid, a nitrogenous organic base, C12-30 fatty alcohol, monoglyceride or the reaction products thereof.

Abstract: A composition capable of forming a film that ionically bonds to the skin comprising: one or more active agents; a nonionic or substantially nonionic first film forming component; one or more cationic surfactants comprising one or more fatty moieties that are soluble in the first film forming component; and a liquid carrier. Also provided are stable emulsions of such compositions, compositions that are especially adapted to delivering medicinal agents to the surface of the skin, and methods for preparing such compositions.

Abstract: A composition capable of forming a film that ionically bonds to the skin comprising one or more active agents, a nonionic or substantially nonionic first film forming component, one or more cationic surfactant and a liquid carrier.

Abstract: Skin and/or wound and burn care compositions and/or phase stable emulsions comprising one or more of the following; organic base salts of fatty acids, fatty esters, fatty alcohols, non-ionic and quaternary ammonium surfactants, and other highly polar compounds, a liquid carrier, and optionally one or more active agents. The compositions and/or phase stable emulsions contain fatty microspheres. The compositions that are especially adapted to topically deliver active and/or medicinal agents to the surface of the skin, burns, skin lesions, warts, and ulcers, and methods for preparing such compositions.

Abstract: A composition capable of forming a film that ionically bonds to the skin comprising one or more active agents; a nonionic or skin comprising: one or more active agents; a nonionic or substantially nonionic first film forming component; one or more cationic surfactants comprising one or more fatty moieties that are soluble in the first film forming component; and a liquid carrier. Also provided are stable emulsions of such compositions, compositions that are especially adapted to delivering medicinal agents to the surface of the skin, and methods for preparing such compositions.

Abstract: A process and apparatus for blow-molding, sterilizing, filling and capping plastic containers under conditions of positive control in a close-coupled, compact machine to enhance operational efficiency.

Abstract: An aquaculture process for dissolving gas in liquid by impinging two or more streams substantially and directly one to the other wherein the two streams enter an impingement zone from conveying means of substantially equal shape with a velocity greater than 2 ft/sec, wherein at least one of the streams is a gas/liquid mixture and at least one of the streams passes through a venturi prior to impingement, the impingement of the two streams taking place above a water line of an environment being discharged into so as to offset the pressure of the fluid discharging from the process, the impingement of the two streams further taking place in a contained environment such that the fluid dynamics of each stream just prior to and after the point of impingement is substantially turbulent, whereby after impingement, the streams are discharged at velocities that have substantially turbulent fluid dynamics with the discharge from the impingement zone not changing direction before discharge to the surrounding environment,