Abstract: A system (100) and method (2000): specify image features (1342/1344/1346) which are to be avoided in selecting a region of interest (10) in tissue of a body for making a shear wave elasticity measurement of the tissue; receive (2020) one or more image signals from an acoustic probe (120) produced from acoustic echoes from an area of the tissue; process (2030) acoustic images (504/506/508) in real-time to identify the image features which are to be avoided in selecting the region of interest; provide (2040) visual feedback to a user to choose a location for the region of interest based on the identified image features; select (2050) the region of interest in response to the visual feedback; and make (2060) the shear wave elasticity measurement of the tissue within the selected region of interest using one or more acoustic radiation force pulses.