Abstract: A ventilated cover for a toothbrush holder is formed to fit closely over a toothbrush cup, and to prevent entry of flies and other insects and airborne pests and carriers of disease organisms within the cup and cover. The cover includes a multitude of very fine holes therethrough, which holes provide air circulation to aid in the drying of the bristles of any toothbrushes contained within the cup and under the cover, but which holes are too small to allow passage of any airborne pests or insects. The cover is preferably formed of plastic, but may alternatively be formed of ceramic, a durable perforated metal, or even a fine mesh screen. The present invention may also include a toothbrush cup and a disc adapted to fit within the upper rim of the cup, with the disc providing upstanding support for one or more toothbrushes held within the cup. The disc may also provide for the positioning of the cover thereover. The cover and/or assembly may be provided in any of a variety of colors and designs, if desired.