Patents by Inventor Guan-Chiun Lee

Guan-Chiun Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9970035
    Abstract: A method for producing biodiesel is provided, which includes providing a recombinant Candida rugosa lipase; reacting the recombinant C. rugosa lipase and a non-edible oil; and isolating the biodiesel from the reacted solution.
    Type: Grant
    Filed: April 21, 2016
    Date of Patent: May 15, 2018
    Assignee: National Taiwan Normal University
    Inventors: Guan-Chiun Lee, Ting-Chun Kuo
  • Publication number: 20170202792
    Abstract: A method for treating a tau-associated disease is disclosed, which comprises the step of administering a pharmaceutical composition to a subject in need. Particularly, a method for treating Alzheimer's disease is disclosed, which comprises the step of administering a pharmaceutical composition to a subject in need.
    Type: Application
    Filed: August 16, 2016
    Publication date: July 20, 2017
    Inventors: Hsiu-Mei HSIEH, Ying-Chieh SUN, Guan-Chiun LEE, Guey-Jen LEE-CHEN, Ming-Tsan SU, Hui-Chen HUANG, Yu-Shao HSIEH, Chia-Jen HSU
  • Publication number: 20170137850
    Abstract: A method for producing biodiesel is provided, which includes providing a recombinant Candida rugosa lipase; reacting the recombinant C. rugosa lipase and a non-edible oil; and isolating the biodiesel from the reacted solution.
    Type: Application
    Filed: April 21, 2016
    Publication date: May 18, 2017
    Inventors: Guan-Chiun LEE, Ting-Chun KUO
  • Patent number: 9629835
    Abstract: A method for treating tau-associated disease by administering a pharmaceutical composition comprising a quinoline derivative to a subject in need is disclosed. Particularly, a method for treating Alzheimer's disease by administering a pharmaceutical composition comprising a quinoline derivative to a subject in need is disclosed. The two disclosed quinoline derivatives have the inhibition effect for GSK-3? kinase activity, so as the two disclosed quinoline derivatives have the ability for inhibiting tau hyperphosphorylation or reducing tau aggregation.
    Type: Grant
    Filed: August 16, 2016
    Date of Patent: April 25, 2017
    Assignee: National Taiwan Normal University
    Inventors: Guey-Jen Lee-Chen, Hsiu-Mei Hsieh, Guan-Chiun Lee, Ying-Chieh Sun
  • Patent number: 9463197
    Abstract: A method for treating an abnormal polyglutamine-mediated disease is disclosed, which comprises: administering a pharmaceutical composition comprising a trehalose-based compound to a subject in need. Additionally, the pharmaceutical composition optionally further comprises a trehalase inhibitor.
    Type: Grant
    Filed: July 15, 2014
    Date of Patent: October 11, 2016
    Assignee: NATIONAL TAIWAN NORMAL UNIVERSITY
    Inventors: Guey-Jen Lee-Chen, Hsiu-Mei Hsieh, Guan-Chiun Lee
  • Publication number: 20150025028
    Abstract: A method for treating an abnormal polyglutamine-mediated disease is disclosed, which comprises: administering a pharmaceutical composition comprising a trehalose-based compound to a subject in need. Additionally, the pharmaceutical composition optionally further comprises a trehalase inhibitor.
    Type: Application
    Filed: July 15, 2014
    Publication date: January 22, 2015
    Inventors: Guey-Jen LEE-CHEN, Hsiu-Mei HSIEH, Guan-Chiun LEE
  • Patent number: 7981639
    Abstract: A method for producing a monosaccharide-rich syrup from starch-containing produce. The method includes treating a starch-containing produce slurry with a first starch hydrolyzing enzyme that hydrolyzes starch to oligosaccharide and a second starch hydrolyzing enzyme that hydrolyzes starch or oligosaccharide to glucose. The starch-containing produce can be further treated with an enzyme that converts glucose to other monosaccharides, or treated with a microorganism that converts glucose to a fermentation product. Also within the scope of this invention is a method for producing a syrup rich in a disaccharide, such as trehalose.
    Type: Grant
    Filed: February 19, 2004
    Date of Patent: July 19, 2011
    Assignee: Academia Sinica
    Inventors: Jei-Fu Shaw, Guan-Chiun Lee, Jen-Jye Chen
  • Patent number: 7927850
    Abstract: The present invention relates to the isolation and functional identification of a novel acid and heat resistant trehalose synthase enzyme cloned from Picrophilus torridus. More particularly, the present invention discloses the DNA sequence for the Picrophilus torridus trehalose synthase gene, PTTS, which when expressed in a heterologous host such as Escherichia coli, provides enzymatic activity that catalyzes the direct interconversion of maltose and trehalose through intramolecular transglycosylation. Additionally, the present invention teaches methods of use of PTTS for production of trehalose as well as for production of various useful compounds comprising trehalose.
    Type: Grant
    Filed: July 21, 2006
    Date of Patent: April 19, 2011
    Assignee: Academia Sinica
    Inventors: Jei-Fu Shaw, Guan-Chiun Lee, Yi-Shan Chen
  • Patent number: 7655453
    Abstract: The present invention features an isolated nucleic acid that includes a mutant DNA encoding a Candida rugosa lipase, wherein the mutant DNA is 80% identical to a wild-type DNA encoding the Candida rugosa lipase, and includes at least 12 (e.g., 13, 15, 17, or all) universal serine codons corresponding to CTG codons in the wild-type DNA. Each of the universal serine codons, independently, is TCT, TCC, TCA, TCG, AGT, or AGC. The Candida rugosa lipase can be Candida rugosa lipase 1, 2, 3, 4, 5, or 8.
    Type: Grant
    Filed: August 20, 2007
    Date of Patent: February 2, 2010
    Assignee: Academia Sinica
    Inventors: Jei-fu Shaw, Guan-chiun Lee, Shye-Jye Tang
  • Publication number: 20090053795
    Abstract: The present invention features an isolated nucleic acid that includes a mutant DNA encoding a Candida rugosa lipase, wherein the mutant DNA is 80% identical to a wild-type DNA encoding the Candida rugosa lipase, and includes at least 12 (e.g., 13, 15, 17, or all) universal serine codons corresponding to CTG codons in the wild-type DNA. Each of the universal serine codons, independently, is TCT, TCC, TCA, TCG, AGT, or AGC. The Candida rugosa lipase can be Candida rugosa lipase 1, 2, 3, 4, 5, or 8.
    Type: Application
    Filed: August 20, 2007
    Publication date: February 26, 2009
    Applicant: Academia Sinica
    Inventors: Jei-Fu Shaw, Guan-chiun Lee, Shye-Jye Tang
  • Patent number: 7468429
    Abstract: The present invention features an isolated nucleic acid that includes a mutant DNA encoding a Candida rugosa lipase, wherein the mutant DNA is 80% identical to a wild-type DNA encoding the Candida rugosa lipase, and includes at least 12 (e.g., 13, 15, 17, or all) universal serine codons corresponding to CTG codons in the wild-type DNA. Each of the universal serine codons, independently, is TCT, TCC, TCA, TCG, AGT, or AGC. The Candida rugosa lipase can be Candida rugosa lipase 1, 2, 3, 4, 5, or 8.
    Type: Grant
    Filed: February 7, 2006
    Date of Patent: December 23, 2008
    Assignee: Academia Sinica
    Inventors: Jei-Fu Shaw, Guan-Chiun Lee, Shye-Jye Tang
  • Publication number: 20080182311
    Abstract: The present invention relates to the isolation and functional identification of a novel acid and heat resistant trehalose synthase enzyme cloned from Picrophilus torridus. More particularly, the present invention discloses the DNA sequence for the Picrophilus torridus trehalose synthase gene, PTTS, which when expressed in a heterologous host such as Escherichia coli, provides enzymatic activity that catalyzes the direct interconversion of maltose and trehalose through intramolecular transglycosylation. Additionally, the present invention teaches methods of use of PTTS for production of trehalose as well as for production of various useful compounds comprising trehalose.
    Type: Application
    Filed: July 21, 2006
    Publication date: July 31, 2008
    Inventors: Jei-Fu Shaw, Guan-Chiun Lee, Yi-Shan Chen
  • Publication number: 20060121528
    Abstract: The present invention features an isolated nucleic acid that includes a mutant DNA encoding a Candida rugosa lipase, wherein the mutant DNA is 80% identical to a wild-type DNA encoding the Candida rugosa lipase, and includes at least 12 (e.g., 13, 15, 17, or all) universal serine codons corresponding to CTG codons in the wild-type DNA. Each of the universal serine codons, independently, is TCT, TCC, TCA, TCG, AGT, or AGC. The Candida rugosa lipase can be Candida rugosa lipase 1, 2, 3, 4, 5, or 8.
    Type: Application
    Filed: February 7, 2006
    Publication date: June 8, 2006
    Inventors: Jei-Fu Shaw, Guan-Chiun Lee, Shye-Jye Tang
  • Patent number: 7052879
    Abstract: The present invention features an isolated nucleic acid that includes a mutant DNA encoding a Candida rugosa lipase, wherein the mutant DNA is 80% identical to a wild-type DNA encoding the Candida rugosa lipase, and includes at least 12 (e.g., 13, 15, 17, or all) universal serine codons corresponding to CTG codons in the wild-type DNA. Each of the universal serine codons, independently, is TCT, TCC, TCA, TCG, AGT, or AGC. The Candida rugosa lipase can be Candida rugosa lipase 1, 2, 3, 4, 5, or 8.
    Type: Grant
    Filed: August 31, 2001
    Date of Patent: May 30, 2006
    Assignee: Academia Sinica
    Inventors: Jei-Fu Shaw, Guan-Chiun Lee, Shye-Jye Tang
  • Publication number: 20040161829
    Abstract: A method for producing a monosaccharide-rich syrup from starch-containing produce. The method includes treating a starch-containing produce slurry with a first starch hydrolyzing enzyme that hydrolyzes starch to oligosaccharide and a second starch hydrolyzing enzyme that hydrolyzes starch or oligosaccharide to glucose. The starch-containing produce can be further treated with an enzyme that converts glucose to other monosaccharides, or treated with a microorganism that converts glucose to a fermentation product. Also within the scope of this invention is a method for producing a syrup rich in a disaccharide, such as trehalose.
    Type: Application
    Filed: February 19, 2004
    Publication date: August 19, 2004
    Inventors: Jei-Fu Shaw, Guan-Chiun Lee, Jen-Jye Chen
  • Publication number: 20030124701
    Abstract: The present invention features an isolated nucleic acid that includes a mutant DNA encoding a Candida rugosa lipase, wherein the mutant DNA is 80% identical to a wild-type DNA encoding the Candida rugosa lipase, and includes at least 12 (e.g., 13, 15, 17, or all) universal serine codons corresponding to CTG codons in the wild-type DNA. Each of the universal serine codons, independently, is TCT, TCC, TCA, TCG, AGT, or AGC. The Candida rugosa lipase can be Candida rugosa lipase 1, 2, 3, 4, 5, or 8.
    Type: Application
    Filed: August 31, 2001
    Publication date: July 3, 2003
    Inventors: Jei-Fu Shaw, Guan-Chiun Lee, Shye-Jye Tang