Abstract: A compound as a BTK inhibitor or an HER2 inhibitor, a preparation method therefor, and a use thereof. The compound comprises a structure as shown in formula II or a tautomer, a mesomer, a racemate, an enantiomer, a diastereomer, or a mixture form thereof, and a pharmaceutically acceptable hydrate, a solvate, or salt. The BTK protein kinase inhibitor of the present invention has strong inhibitory activity on wild-type BTK or mutated BTK (C481S), and some of the compounds have high brain permeability; the HER2 inhibitor of the present invention has good HER2 kinase inhibitory activity and high blood-brain barrier transmittance; and the compound of the present invention has good pharmacokinetic properties and a good application prospect.

Abstract: A compound serving as a BTK inhibitor, a preparation method therefor, and a use thereof. The compound has a structure represented by formula I, or a tautomer, a mesomer, a racemate, an enantiomer, a diastereomer or a mixture thereof, or a pharmaceutically acceptable hydrate, solvent, or salt thereof, wherein A1, A2, A3, A4, A5 and A6 are each independently selected from C—R5 and N, and at least one of those is N; and M is selected from substituted or unsubstituted saturated or heterosaturated hydrocarbyl, substituted or unsubstituted unsaturated cyclic group or heterocyclyl, and substituted or unsubstituted monocyclic, bicyclic, or tricyclic aryl or heteroaryl. The provided BTK protein kinase inhibitor has strong inhibition for wild BTK and mutated BTK (C481S), has good pharmacokinetic properties, and has good application prospects.

Abstract: A light bulb includes a bulb shell, a light source, a driver, a head housing and a bottom switch. The light source is enclosed by the bulb shell for emitting a light through the bulb shell. The driver converts an external power to a driving current supplied to the light source. The head housing has an Edison cap. The head housing is coupled to the bulb shell. The driver is enclosed by the head housing. The Edison cap is plugged to an Edison socket for receiving the external power source. The bottom switch is disposed on the bottom of the Edison cap for changing a setting of the driver.

Abstract: A light bulb includes a bulb shell, a light source, a driver, a head housing and a bottom switch. The light source is enclosed by the bulb shell for emitting a light through the bulb shell. The driver converts an external power to a driving current supplied to the light source. The head housing has an Edison cap. The head housing is coupled to the bulb shell. The driver is enclosed by the head housing. The Edison cap is plugged to an Edison socket for receiving the external power source. The bottom switch is disposed on the bottom of the Edison cap for changing a setting of the driver.

Abstract: The present invention provides a compound having a structure shown in formula (I) or an isomer, pharmaceutically acceptable solvate, or salt thereof. The compound is used as a Bruton's tyrosine kinase inhibitor, and has a higher inhibitory activity against BTK and less adverse effects.

Abstract: The present invention provides a compound having a structure shown in formula (I) or an isomer, pharmaceutically acceptable solvate, or salt thereof. The compound is used as a Bruton's tyrosine kinase inhibitor, and has a higher inhibitory activity against BTK and less adverse effects.