Abstract: A trust rule between a first service and a second service in a plurality of services deployed in a distributed system is received; the trust rule defines whether the first service is allowed to access the second service. A trust tree is obtained for the distributed system, and the trust tree comprises a plurality of certificates for accessing the plurality of services. A first group of certificates is selected for the first service based on the trust rule and the trust tree, and the first group of certificates enables the first service to access the second service.

Abstract: A method, system, and computer program product for detecting out-of-date runbooks are disclosed. The method may include generating a defect corresponding to an alert on a running workload system. The method may further include, in response to generating the defect in the running workload system, automatically obtaining an identification of a runbook based on information of the alert, automatically accessing the runbook based on the identification of the runbook, the runbook including instructions for fixing the defect, automatically parsing the instructions to obtain executable operations, and automatically executing the executable operations on the running workload system. The method may further include, in response to detecting that the alert is not solved on the running workload system after a predefined period, automatically determining that the runbook is out-of-date, and automatically generating a runbook out-of-date signal.

Abstract: A trust rule between a first service and a second service in a plurality of services deployed in a distributed system is received; the trust rule defines whether the first service is allowed to access the second service. A trust tree is obtained for the distributed system, and the trust tree comprises a plurality of certificates for accessing the plurality of services. A first group of certificates is selected for the first service based on the trust rule and the trust tree, and the first group of certificates enables the first service to access the second service.

Abstract: A method, system, and computer program product for detecting out-of-date runbooks are disclosed. The method may include generating a defect corresponding to an alert on a running workload system. The method may further include, in response to generating the defect in the running workload system, automatically obtaining an identification of a runbook based on information of the alert, automatically accessing the runbook based on the identification of the runbook, the runbook including instructions for fixing the defect, automatically parsing the instructions to obtain executable operations, and automatically executing the executable operations on the running workload system. The method may further include, in response to detecting that the alert is not solved on the running workload system after a predefined period, automatically determining that the runbook is out-of-date, and automatically generating a runbook out-of-date signal.

Abstract: Computerized aspects monitor listening virtual local area network ports for multicast packets from hypervisor virtual machines that meet a multicast group definition, and retrieve source addresses for original hypervisor sources of detected ones of the multicast packets, bind the retrieved addresses to the multicast packets to generate encapsulated packets, and forward the encapsulated packets as user datagram protocol unicast packets to a destination address of a virtual extensible helper daemon defined for a destination hypervisor of a second virtual local area network. The destination address meets the multicast group definition for the first virtual local area network, and the second virtual local area network is geographically remote from and different from the first virtual local area network, and thus the aspects send the first user datagram protocol unicast packet through an internet protocol router to the designated receiving port.

Abstract: Computerized aspects monitor listening virtual local area network ports for multicast packets from hypervisor virtual machines that meet a multicast group definition, and retrieve source addresses for original hypervisor sources of detected ones of the multicast packets, bind the retrieved addresses to the multicast packets to generate encapsulated packets, and forward the encapsulated packets as user datagram protocol unicast packets to a destination address of a virtual extensible helper daemon defined for a destination hypervisor of a second virtual local area network. The destination address meets the multicast group definition for the first virtual local area network, and the second virtual local area network is geographically remote from and different from the first virtual local area network, and thus the aspects send the first user datagram protocol unicast packet through an internet protocol router to the designated receiving port.

Abstract: Computerized aspects monitor listening virtual local area network ports for multicast packets from hypervisor virtual machines that meet a multicast group definition, and retrieve source addresses for original hypervisor sources of detected ones of the multicast packets, bind the retrieved addresses to the multicast packets to generate encapsulated packets, and forward the encapsulated packets as user datagram protocol unicast packets to a destination address of a virtual extensible helper daemon defined for a destination hypervisor of a second virtual local area network. The destination address meets the multicast group definition for the first virtual local area network, and the second virtual local area network is geographically remote from and different from the first virtual local area network, and thus the aspects send the first user datagram protocol unicast packet through an internet protocol router to the designated receiving port.

Abstract: Computerized aspects monitor listening virtual local area network ports for multicast packets from hypervisor virtual machines that meet a multicast group definition, and retrieve source addresses for original hypervisor sources of detected ones of the multicast packets, bind the retrieved addresses to the multicast packets to generate encapsulated packets, and forward the encapsulated packets as user datagram protocol unicast packets to a destination address of a virtual extensible helper daemon defined for a destination hypervisor of a second virtual local area network. The destination address meets the multicast group definition for the first virtual local area network, and the second virtual local area network is geographically remote from and different from the first virtual local area network, and thus the aspects send the first user datagram protocol unicast packet through an internet protocol router to the designated receiving port.

Abstract: The present invention relates to the three dimensional solution structure of the N-terminal domain of TNFR-1 associated death domain protein (“N-TRADD”), as well as the identification and characterization of a C-TRAF2 binding active site of N-TRADD. Also provided for by the present invention are methods of utilizing the three dimensional structures for the design and selection of potent and selective inhibitors of TNF signaling pathways.

Abstract: The present invention relates to the three dimensional solution structure of receptor interacting protein dead domain (RIP DD), as well as the identification and characterization of various binding active sites of RIP DD. Also provided for by the present invention are methods of utilizing the three dimensional structure for the design and selection of potent and selective inhibitors of TNF signaling pathways.

Abstract: The present invention relates to the three dimensional solution structure of the N-terminal domain of TNFR-1 associated death domain protein (“N-TRADD”), as well as the identification and characterization of a C-TRAF2 binding active site of N-TRADD. Also provided for by the present invention are methods of utilizing the three dimensional structures for the design and selection of potent and selective inhibitors of TNF signaling pathways.

Abstract: This invention is directed to the crystal structure of Acyl Carrier Protein Synthase (ACPS) complexed with Acyl Carrier Protein (ACP), the solution structure of B. subtilis ACP, and to the use of these structures in rational drug design methods to identify agents that may interact with active sites of ACPS and ACP, and to the testing of these agents to identify agents that may represent novel antibiotics.

Abstract: This invention is directed to the crystal structure of Acyl Carrier Protein Synthase (ACPS) complexed with Acyl Carrier Protein (ACP), the solution structure of B. subtilis ACP, and to the use of these structures in rational drug design methods to identify agents that may interact with active sites of ACPS and ACP, and to the testing of these agents to identify agents that may represent novel antibiotics.

Abstract: The present invention relates to the three dimensional solution structure of receptor interacting protein dead domain (RIP DD), as well as the identification and characterization of various binding active sites of RIP DD. Also provided for by the present invention are methods of utilizing the three dimensional structure for the design and selection of potent and selective inhibitors of TNF signaling pathways.

Abstract: This invention is directed to the crystal structure of Acyl Carrier Protein Synthase (ACPS) complexed with Acyl Carrier Protein (ACP), the solution structure of B. subtilis ACP, and to the use of these structures in rational drug design methods to identify agents that may interact with active sites of ACPS and ACP, and to the testing of these agents to identify agents that may represent novel antibiotics.

Abstract: Crystallographic and NMR solution structures of human IL-6 are reported. The invention provides models and systems incorporating such structures which are useful for identifying IL-6/IL-6 receptor interactions and for identification of agonists and antagonists of such interactions. Crystalline human IL-6 is also provided.

Abstract: Crystallographic and NMR solution structures of human IL-6 are reported. The invention provides models and systems incorporating such structures which are useful for identifying IL-6/IL-6 receptor interactions and for identification of agonists and antagonists of such interactions. Crystalline human IL-6 is also provided.

Abstract: The present invention relates to the three dimensional solution structure of the N-terminal domain of TNFR-1 associated death domain protein (“N-TRADD”), as well as the identification and characterization of a C-TRAF2 binding active site of N-TRADD. Also provided for by the present invention are methods of utilizing the three dimensional structures for the design and selection of potent and selective inhibitors of TNF signaling pathways.

Abstract: The present invention relates to the three dimensional solution structure of tumor necrosis factor receptor 1 death domain (TNFR-1 DD), as well as the identification and characterization of various binding active sites of TNFR-1 DD. Also provided for by the present invention are methods of utilizing the three dimensional structure for the design and selection of potent and selective inhibitors of TNF signaling pathways.