Patents by Inventor Guang-Yuh Chiou

Guang-Yuh Chiou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MicroRNA as a cancer progression predictor and its use for treating cancer
    Patent number: 9107934
    Abstract: The present invention is based on the findings that a novel function for miR142-3p in the regulation of Sox2, adenylyl cyclase 9 (AC9), and CD133 expressions, and consequently the overall stemness of recurrent GBM cells as well as CSCs, and that miR142-3p modulated tumor-initiating properties in recurrent GBM. The present invention consequently supports the development of novel miRNA-based strategies for brain tumor treatment.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: August 18, 2015
    Assignee: Taipei Veterans General Hospital
    Inventors: Shih-Hwa Chiou, Guang-Yuh Chiou
  • METHOD FOR PREPARING INDUCED PLURIPOTENT STEM CELLS AND ITS APPLICATIONS
    Publication number: 20140093486
    Abstract: The present invention relates to a novel method for preparing induced pluripotent stem cells (iPSCs) by introducing three genes, Oct3/4, Sox2, and Parp1, into somatic cells. The present invention also relates to the iPSCs produced by the aforementioned method. Also provided is a method of rejuvenating cells by use of a PARylated protein or an enzyme with PARylation activity. Further provided is a method for inducing the secretion of interferon-? inducible protein-10 (IP-10) comprising administering to a subject in need thereof an effective amount of iPSCs or iPSC-CM.
    Type: Application
    Filed: October 1, 2013
    Publication date: April 3, 2014
    Applicant: Taipei Veterans General Hospital
    Inventors: SHIH-HWA CHIOU, YUEH CHIEN, GUANG-YUH CHIOU, YI-PING YANG
  • MicroRNA as a cancer progression predictor and its use for treating cancer
    Patent number: 8404437
    Abstract: The present invention is based on the findings that a novel function for miR142-3p in the regulation of Sox2, adenylyl cyclase 9 (AC9), and CD133 expressions, and consequently the overall stemness of recurrent GBM cells as well as CSCs, and that miR142-3p modulated tumor-initiating properties in recurrent GBM. The present invention consequently supports the development of novel miRNA-based strategies for brain tumor treatment.
    Type: Grant
    Filed: March 29, 2011
    Date of Patent: March 26, 2013
    Assignee: Taipei Veterans General Hospital
    Inventors: Shih-Hwa Chiou, Guang-Yuh Chiou
  • MICRORNA AS A CANCER PROGRESSION PREDICTOR AND ITS USE FOR TREATING CANCER
    Publication number: 20120255043
    Abstract: The present invention is based on the findings that a novel function for miR142-3p in the regulation of Sox2, adenylyl cyclase 9 (AC9), and CD133 expressions, and consequently the overall stemness of recurrent GBM cells as well as CSCs, and that miR142-3p modulated tumor-initiating properties in recurrent GBM. The present invention consequently supports the development of novel miRNA-based strategies for brain tumor treatment.
    Type: Application
    Filed: March 29, 2011
    Publication date: October 4, 2012
    Applicant: TAIPEI VETERANS GENERAL HOSPITAL
    Inventors: Shih-Hwa Chiou, Guang-Yuh Chiou