Patents by Inventor Guangchao Xu

Guangchao Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AAV CAPSID DESIGNS
    Publication number: 20230374545
    Abstract: The disclosure in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capabilities. In some aspects, the disclosure relates to gene transfer methods using the recombinant adeno-associated viruses. In some aspects, the disclosure relates to isolated AAV capsid proteins and isolated nucleic acids encoding the same.
    Type: Application
    Filed: January 5, 2023
    Publication date: November 23, 2023
    Applicants: University of Massachusetts, Sichuan University
    Inventors: Guangping Gao, Guangchao Xu, Phillip Tai, Yuquan Wei, Li Luo
  • AAV CAPSIDS VARIANTS AND USES THEREOF
    Publication number: 20230138766
    Abstract: Aspects of the disclosure relate to compositions and methods for delivering a transgene (e.g., a transgene encoding one or more gene products) to a target cell. The disclosure is based, in part, on adeno-associated virus (AAV) capsid protein variants characterized by tropisms for certain cell types (e.g., neurons, muscle cells, bone cells, heart cells, etc.). In some embodiments, recombinant A A Vs (rAAVs) comprising the capsid protein variants (e.g., AAVv66, SEQ ID NO: 1) are more efficiently packaged than rAAVs having certain wild-type AAV capsid proteins. Methods of delivering an rAAV comprising the AAV capsid protein variants are also described by the disclosure.
    Type: Application
    Filed: March 30, 2021
    Publication date: May 4, 2023
    Applicants: University of Massachusetts, Sichuan University
    Inventors: Guangping Gao, Guangchao Xu, Phillip Tai, Yuquan Wei, Li Luo
  • AAV capsid designs
    Patent number: 11578340
    Abstract: The disclosure in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capabilities. In some aspects, the disclosure relates to gene transfer methods using the recombinant adeno-associated viruses. In some aspects, the disclosure relates to isolated AAV capsid proteins and isolated nucleic acids encoding the same.
    Type: Grant
    Filed: October 13, 2017
    Date of Patent: February 14, 2023
    Assignees: University of Massachusetts, Sichuan University
    Inventors: Guangping Gao, Guangchao Xu, Phillip Tai, Yuquan Wei, Li Luo
  • AAV CAPSID DESIGNS
    Publication number: 20200316221
    Abstract: The disclosure in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capabilities. In some aspects, the disclosure relates to gene transfer methods using the recombinant adeno-associated viruses. In some aspects, the disclosure relates to isolated AAV capsid proteins and isolated nucleic acids encoding the same.
    Type: Application
    Filed: April 7, 2020
    Publication date: October 8, 2020
    Applicant: University of Massachusetts
    Inventors: Guangping Gao, Guangchao Xu, Phillip Tai, Yuquan Wei, Li Luo
  • AAV CAPSID DESIGNS
    Publication number: 20190300904
    Abstract: The disclosure in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capabilities. In some aspects, the disclosure relates to gene transfer methods using the recombinant adeno-associated viruses. In some aspects, the disclosure relates to isolated AAV capsid proteins and isolated nucleic acids encoding the same.
    Type: Application
    Filed: October 13, 2017
    Publication date: October 3, 2019
    Applicant: University of Massachusetts
    Inventors: Guangping Gao, Guangchao Xu, Phillip Tai, Yuquan Wei, Li Luo