Patents by Inventor Guangfei Huang

Guangfei Huang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing Z-endoxifen of high purity
    Patent number: 10464881
    Abstract: Disclosed is a process for preparing (Z)-endoxifen, comprising (i) recrystallizing an input crystalline solid comprising a mixture of (Z)-endoxifen (1) and (E)-endoxifen (2) from a first solvent to provide a first crystalline solid and a first mother liquor, wherein the first mother liquor has a ratio of (1) to (2) at least 1.3 times greater than the ratio in the input crystalline solid (1) and (2); (ii) recrystallizing a solid produced by concentrating the first mother liquor, or by removal of the first solvent from the first mother liquor, from a second solvent to give a second crystalline solid and a second mother liquor; (iii) optionally recrystallizing the second crystalline solid from the second solvent one to five additional times to give a third crystalline solid; wherein the third crystalline solid has a ratio of (Z)-endoxifen (1) to (E)-endoxifen (2) greater than 20:1.
    Type: Grant
    Filed: October 24, 2016
    Date of Patent: November 5, 2019
    Assignees: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, ALCHEM LABORATORIES CORPORATION
    Inventors: Paul S. Liu, Sergiy M. Denysenko, Guangfei Huang
  • PROCESS FOR PREPARING Z-ENDOXIFEN OF HIGH PURITY
    Publication number: 20180305295
    Abstract: Disclosed is a process for preparing (Z)-endoxifen, comprising (i) recrystallizing an input crystalline solid comprising a mixture of (Z)-endoxifen (1) and (E)-endoxifen (2) from a first solvent to provide a first crystalline solid and a first mother liquor, wherein the first mother liquor has a ratio of (1) to (2) at least 1.3 times greater than the ratio in the input crystalline solid (1) and (2); (ii) recrystallizing a solid produced by concentrating the first mother liquor, or by removal of the first solvent from the first mother liquor, from a second solvent to give a second crystalline solid and a second mother liquor; (iii) optionally recrystallizing the second crystalline solid from the second solvent one to five additional times to give a third crystalline solid; wherein the third crystalline solid has a ratio of (Z)-endoxifen (1) to (E)-endoxifen (2) greater than 20:1.
    Type: Application
    Filed: October 24, 2016
    Publication date: October 25, 2018
    Inventors: Paul S. LIU, Sergiy M. DENYSENKO, Guangfei HUANG
  • Pyrimidinone compounds as calcilytics
    Patent number: 7491728
    Abstract: The pyrimidinone compounds are disclosed. Methods of preparing the pyrimidinone compounds are also disclosed.
    Type: Grant
    Filed: April 7, 2004
    Date of Patent: February 17, 2009
    Assignee: SmithKline Beecham Corp.
    Inventors: Irina V. Shcherbakova, Manuel F. Balanddrin, Guangfei Huang, Otto Geoffroy, John Fox, Robert Marquis, Dennis Shinji Yamashita, Juan Luengo, Wenyong Wang
  • Pyrimidinone Compounds As Calcilytics
    Publication number: 20070197555
    Abstract: The pyrimidinone compounds are disclosed. Methods of preparing the pyrimidinone compounds are also disclosed.
    Type: Application
    Filed: April 7, 2004
    Publication date: August 23, 2007
    Inventors: Irina Shcherbakova, Manuel Balandrin, Guangfei Huang, Otto Geoffroy, John Fox, Robert Marquis, Dennis Yamashita, Juan Luengo, Wenyong Wang
  • Methods for preparing 2,3,5,6-substituted 3h-pyrimidin-4-ones
    Publication number: 20070161792
    Abstract: Pyrimidinone compounds are disclosed. Methods of preparing the pyrimidinone compounds are also disclosed.
    Type: Application
    Filed: April 7, 2004
    Publication date: July 12, 2007
    Applicant: NPS PHARMACUETICALS, INC
    Inventors: Irina Shcherbakova, Manuel Balandria, Guangfei Huang, Otto Geoffroy, John Fox, Satheesh Nair