Abstract: The present disclosure provides a compound of formula (I), or an isotopically labeled product, an enantiomer, a diastereomer or a pharmaceutically acceptable salt thereof; a pharmaceutical composition comprising a compound of formula (I); and use of a compound of formula (I) or a pharmaceutical composition thereof in the treatment of diabetes mellitus and related symptoms.

Abstract: A method for preparing a substituted acrylate compound of general formula (I) is provided.

Abstract: The present invention is directed to an efficient process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form of formula I wherein R1 and R2 independently denote C1-3-alkyl groups and X? denotes an acid anion, such as the chloride, bromide, tosylate, mesylate or trifluoroacetate anion, with high quality, and a process for synthesis of EGFR tyrosine kinase inhibitors with heterocyclic quinazoline, quinoline or pyrimidopyrimidine core structure, using the acid addition salt I and activated derivatives thereof as intermediates.

Abstract: The present invention is directed to an efficient process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form of formula I wherein R1 and R2 independently denote C1-3-alkyl groups and X? denotes an acid anion, such as the chloride, bromide, tosylate, mesylate or trifluoroacetate anion, with high quality, and a process for synthesis of EGFR tyrosine kinase inhibitors with heterocyclic quinazoline, quinoline or pyrimidopyrimidine core structure, using the acid addition salt I and activated derivatives thereof as intermediates.

Abstract: A tool trolley for an electrolysis multifunctional machine set comprises: a frame (1); a hopper (2) fixed to the frame; a tool rotarytable (3) disposed at the lower portion of the hopper and rotatable around the hopper; an operating cab (4) disposed below the center of the tool rotarytable; a crust breaking tool (5), an anode replacing tool (6), a grab bucket tool (7) for cleaning anode pit and a feeding tool (8) of the tool rotarytable flexibly connected to the tool rotarytable disposed around the operating cab; a rotation drive mechanism (13) disposed between the hopper and the tool rotarytable. The tools are radially configured around the operating cab which is rotatable within ±190 degrees or stationary, and meanwhile, the operating console in the operating cab may also be rotated ±90 degrees. Therefore, it is convenient for operation, and the operator is provided with a wider view. The tool trolley is simple in structure, and can be installed and maintained in an easier and quicker manner.