Patents by Inventor Guanghua Yan
Guanghua Yan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240025905Abstract: Salts of dihydropyrimidine derivatives, complexes and uses thereof in medicine, and complexes and pharmaceutical compositions thereof. The uses of the addition salts, the complexes or the pharmaceutical compositions in the manufacture of a medicament, especially in the manufacture of a medicament for preventing, managing, treating or lessening hepatitis B virus (HBV) infection.Type: ApplicationFiled: November 30, 2021Publication date: January 25, 2024Applicant: SUNSHINE LAKE PHARMA CO., LTD.Inventors: Qingyun REN, Xinchang LIU, Yingjun ZHANG, Guanghua YAN
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Publication number: 20220194951Abstract: A dihydropyrimidine compound and application thereof as a drug, in particular, application as a drug for treating and preventing hepatitis B. Specifically, a compound represented by general formula (I) or (Ia) or a stereoisomer, a tautomer, an oxynitride, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, wherein variables are as defined in the description. Use of the compound represented by general formula (I) or (Ia) or the stereoisomer, the tautomer, the oxynitride, the solvate, the metabolite, or the pharmaceutically acceptable salt thereof as a drug, in particular use as a drug for treating and preventing hepatitis B.Type: ApplicationFiled: April 29, 2020Publication date: June 23, 2022Applicant: SUNSHINE LAKE PHARMA CO., LTD.Inventors: Qingyun REN, Yingjun ZHANG, Xinchang LIU, Siegfried GOLDMANN, Guanghua YAN, Meng WANG, Douxing LEI, Feng LI
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Patent number: 11261190Abstract: A dihydropyrimidine compound and use as a medicament, especially application as a medicament used for treating and preventing hepatitis B, specifically, is a compound having Formula (I) or (Ia), or a stereoisomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, wherein the variables of the formulas are as defined in the specification; and also includes the use of the compound having Formula (I) or (Ia), or an enantiomer, a diastereoisomer, a tautomer, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof as a medicament, especially use as a medicament for treating and preventing hepatitis B.Type: GrantFiled: October 17, 2018Date of Patent: March 1, 2022Assignee: SUNSHINE LAKE PHARMA CO., LTD.Inventors: Xinchang Liu, Qingyun Ren, Guanghua Yan, Siegfried Goldmann, Yingjun Zhang
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Patent number: 10966970Abstract: A fused tricyclic compound and use thereof as a medicament, in particular as a medicament for the treatment and/or prevention of hepatitis B. Specifically, a compound having Formula (I) or a stereoisomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, wherein each variate is as defined in specification. The compound also includes a Formula (I) or a stereoisomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof as a medicament, especially as a medicament for the treatment and/or prevention of hepatitis B.Type: GrantFiled: June 2, 2018Date of Patent: April 6, 2021Assignee: SUNSHINE LAKE PHARMA CO., LTD.Inventors: Xinchang Liu, Qingyun Ren, Jianzhou Huang, Zhimin Xiong, Jinfeng Xiong, You Li, Yang Liu, Zhifu Zou, Guanghua Yan, Siegfried Goldmann, Yingjun Zhang
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Publication number: 20200283445Abstract: A dihydropyrimidine compound and use as a medicament, especially application as a medicament used for treating and preventing hepatitis B, specifically, is a compound having Formula (I) or (Ia), or a stereisomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, wherein the variables of the formulas are as defined in the specification; and also includes the use of the compound having Formula (I) or (Ia), or an enantiomer, a diastereoisomer, a tautomer, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof as a medicament, especially use as a medicament for treating and preventing hepatitis B.Type: ApplicationFiled: October 17, 2018Publication date: September 10, 2020Applicant: SUNSHINE LAKE PHARMA CO., LTD.Inventors: Xinchang LIU, Qingyun REN, Guanghua YAN, Siegfried GOLDMANN, Yingjun ZHANG
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Publication number: 20200113879Abstract: A fused tricyclic compound and use thereof as a medicament, in particular as a medicament for the treatment and/or prevention of hepatitis B. Specifically, a compound having Formula (I) or a stereoisomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, wherein each variate is as defined in specification. The compound also includes a Formula (I) or a stereoisomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof as a medicament, especially as a medicament for the treatment and/or prevention of hepatitis B.Type: ApplicationFiled: June 2, 2018Publication date: April 16, 2020Applicants: SUNSHINE LAKE PHARMA CO., LTD., NORTH & SOUTH BROTHER PHARMACY INVESTMENT COMPANY LIMITEDInventors: Xinchang LIU, Qingyun REN, Jianzhou HUANG, Zhimin XIONG, Jinfeng XIONG, You LI, Yang LIU, Zhifu ZOU, Guanghua YAN, Siegfried GOLDMANN, Yingjun ZHANG
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Patent number: 10471278Abstract: A cranial alignment device for use in intracranial stereotactic radiotherapy includes a nosepiece that is custom shaped to mate with the dorsum and alae of the patient's nose.Type: GrantFiled: June 26, 2014Date of Patent: November 12, 2019Assignee: University of Florida Research Foundation, IncorporatedInventors: Kathryn Elizabeth Mittauer, Guanghua Yan, Richard Helmig, Chihray Liu, Bo Lu
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Patent number: 10098889Abstract: This invention relates to L-tartaric acid complexes, acid addition salts, base addition salts of the compound named (S)-4-(((R)-6-(2-chloro-4-fluorophenyl)-5-(methoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl) morpholine-3-carboxylic acid or tautomer thereof and pharmaceutical compositions thereof, and further relates to use of the compounds or the pharmaceutical compositions in the manufacture of a medicament, especially for use in preventing, managing, treating or lessening a HBV infection. The complex, acid addition salt or base addition salt of the present invention is crystalline form, substantially crystalline form, polymorphism, amorphism, hydrate or solvate.Type: GrantFiled: February 1, 2016Date of Patent: October 16, 2018Assignee: SUNSHINE LAKE PHARMA CO., LTD.Inventors: Qingyun Ren, Liang Chen, Xinchang Liu, Jinsheng Liang, Chenliang Wu, Zhifu Zou, Guanghua Yan, Desheng Huangfu, Siegfried Goldmann, Yingjun Zhang
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Publication number: 20180263991Abstract: This invention relates to L-tartaric acid complexes, acid addition salts, base addition salts of the compound named (S)-4-(((R)-6-(2-chloro-4-fluorophenyl)-5-(methoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl) methyl) morpholine-3-carboxylic acid or tautomer thereof and pharmaceutical compositions thereof, and further relates to use of the compounds or the pharmaceutical compositions in the manufacture of a medicament, especially for use in preventing, managing, treating or lessening a HBV infection. The complex, acid addition salt or base addition salt of the present invention is crystalline form, substantially crystalline form, polymorphism, amorphism, hydrate or solvate.Type: ApplicationFiled: February 1, 2016Publication date: September 20, 2018Applicant: SUNSHINE LAKE PHARMA CO., LTDInventors: Qingyun Ren, Liang CHEN, Xinchang LIU, Jinsheng LIANG, Chenliang WU, Zhifu ZOU, Guanghua YAN, Desheng HUANGFU, Siegfried GOLDMANN, Yingjun ZHANG
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Patent number: 9573941Abstract: The present invention relates to processes for preparing a dihydropyrimidine derivative having Formula (I) or a tautomer thereof having Formula (Ia), as well as a intermediate thereof. The processes of the invention have simple operation, high optical purity of product, high yield and convenient work-up, which is suitable for industrial production.Type: GrantFiled: November 27, 2014Date of Patent: February 21, 2017Assignee: SUNSHINE LAKE PHARMA CO., LTD.Inventors: Qingyun Ren, Xinchang Liu, Zhifu Zou, Guanghua Yan, Mingchao Bi, Siegfried Goldmann, Yingjun Zhang
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Patent number: 9561387Abstract: An ambiguity-free optical tracking system (100) includes a position sensor unit (104), a control box (106), a computer (110) and software. The position sensor unit includes two cameras (121 and 122) that track a plurality of individual infra-red reflecting markers (160) affixed on a patient's skin. Coordinates of the cameras in a coordinate system of the cameras are determined as part of a system calibration process by intentionally creating ambiguous markers with two true markers. Using this information, an ambiguity elimination algorithm automatically identifies and eliminates ambiguous markers. A recursive backtracking algorithm builds a one-to-one correspondence between reference markers and markers optically observed during treatment. By utilizing a concept of null markers, the backtracking algorithm deals with missing, misplaced and occluded markers.Type: GrantFiled: April 12, 2013Date of Patent: February 7, 2017Assignee: Unitversity of Florida Research Foundation, Inc.Inventors: Guanghua Yan, Bo Lu, Chihray Liu, Jonathan G. Li
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Patent number: 9511243Abstract: A patient safety system (PSS) (100) uses optical tracking in a linear accelerator treatment room to prevent gross setup errors. A patient (150) undergoes a computed tomography (CT) treatment-simulation scan while a CT ball bearing (BB) is on patient's surface. The CT BB is replaced with an infrared reflective marker (IRRM) (160) before radiotherapy treatment starts. Coordinates of the CT BB relative to an isocenter of the treatment room are used as reference for tracking. The coordinate system of an optical tracking system is converted to a coordinate system of the treatment room. The PSS evaluates setup accuracy for a radiotherapy session by comparing real-time position of the single IRRM determined by the optical tracking technology with a predicted reference position, and displays results on a graphical user interface. The PSS stops radiation when a deviation between real-time coordinates and predicted coordinates of the IRRM (160) exceeds a predefined threshold.Type: GrantFiled: April 12, 2013Date of Patent: December 6, 2016Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.Inventors: Guanghua Yan, Bo Lu, Chihray Liu, Jonathan G. Li
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Patent number: 9468416Abstract: A jig for calibrating an image-guided radiotherapy apparatus is disclosed. The jig includes a ball bearing and a three-axis positioner. Once the ball bearing has been moved to the calculated radiation isocenter of the apparatus, other calibration procedures can be performed by directing light onto the jig.Type: GrantFiled: June 3, 2014Date of Patent: October 18, 2016Assignee: University of Florida Research Foundation, Inc.Inventors: Chihray Liu, Guanghua Yan
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Publication number: 20160244438Abstract: The present invention relates to processes for preparing a dihydropyrimidine derivative having Formula (I) or a tautomer thereof having Formula (Ia), as well as a intermediate thereof. The processes of the invention have simple operation, high optical purity of product, high yield and convenient work-up, which is suitable for industrial production.Type: ApplicationFiled: November 27, 2014Publication date: August 25, 2016Applicant: SUNSHINE LAKE PHARMA CO., LTD.Inventors: Qingyun REN, Xinchang LIU, Zhifu ZOU, Guanghua YAN, Mingchao BI, Siegfried GOLDMANN, Yingjun ZHANG
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Publication number: 20150374443Abstract: A cranial alignment device for use in intracranial stereotactic radiotherapy includes a nosepiece that is custom shaped to mate with the dorsum and alae of the patient's nose.Type: ApplicationFiled: June 26, 2014Publication date: December 31, 2015Applicant: University of Florida Research Foundation, IncorporatedInventors: Kathryn Elizabeth Mittauer, Guanghua Yan, Richard Helmig, Chihray Liu, Bo Lu
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Publication number: 20150343239Abstract: A jig for calibrating an image-guided radiotherapy apparatus is disclosed. The jig includes a ball bearing and a three-axis positioner. Once the ball bearing has been moved to the calculated radiation isocenter of the apparatus, other calibration procedures can be performed by directing light onto the jig.Type: ApplicationFiled: June 3, 2014Publication date: December 3, 2015Applicant: University of Florida Research Foundation, IncorporatedInventors: Chihray Liu, Guanghua Yan
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Publication number: 20150126796Abstract: A patient safety system (PSS) (100) uses optical tracking in a linear accelerator treatment room to prevent gross setup errors. A patient (150) undergoes a computed tomography (CT) treatment-simulation scan while a CT ball bearing (BB) is on patient's surface. The CT BB is replaced with an infrared reflective marker (IRRM) (160) before radiotherapy treatment starts. Coordinates of the CT BB relative to an isocenter of the treatment room are used as reference for tracking. The coordinate system of an optical tracking system is converted to a coordinate system of the treatment room. The PSS evaluates setup accuracy for a radiotherapy session by comparing real-time position of the single IRRM determined by the optical tracking technology with a predicted reference position, and displays results on a graphical user interface. The PSS stops radiation when a deviation between real-time coordinates and predicted coordinates of the IRRM (160) exceeds a predefined threshold.Type: ApplicationFiled: April 12, 2013Publication date: May 7, 2015Applicant: University of Florida Research Foundation, Inc.Inventors: Guanghua Yan, Bo Lu, Chihray Liu, Jonathan G. Li
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Publication number: 20150085072Abstract: An ambiguity-free optical tracking system (100) includes a position sensor unit (104), a control box (106), a computer (110) and software. The position sensor unit includes two cameras (121 and 122) that track a plurality of individual infra-red reflecting markers (160) affixed on a patient's skin. Coordinates of the cameras in a coordinate system of the cameras are determined as part of a system calibration process by intentionally creating ambiguous markers with two true markers. Using this information, an ambiguity elimination algorithm automatically identifies and eliminates ambiguous markers. A recursive backtracking algorithm builds a one-to-one correspondence between reference markers and markers optically observed during treatment. By utilizing a concept of null markers, the backtracking algorithm deals with missing, misplaced and occluded markers.Type: ApplicationFiled: April 12, 2013Publication date: March 26, 2015Inventors: Guanghua Yan, Bo Lu, Chihray Liu, Jonathan G. Li