Publication number: 20250236894
Abstract: The invention provides a Hemsleya chinensis cytochrome oxidase HcCYP87D19 gene, and the sequence of the gene is shown in SEQ NO: 1. This invention constructs a transgenic Saccharomyces cerevisiae engineering bacteria co-transfected with Hemsleya cathayensis cytochrome oxidase HcCYP87D19 and HcCYP81Q58, the bacteria can produce a variety of cucurbitacin intermediates including 11-Carbonyl-cucurbita-5,23-diene-3?,16a,20,25-tetrol (6), 11-Carbonyl-cucurbita-5,23-diene-3?,16?,20,23-tetrol (6b), 11-Carbonyl-cucurbita-5,23-diene-16?,20,25-triol-3-one (6a), 11-Carbonyl-cucurbita-5,24-diene-16?,20,23-triol-3-one (6c), it provides a source for cucurbitacin production.
Type:
Application
Filed:
January 8, 2025
Publication date:
July 24, 2025
Applicants:
Yunnan Agricultural University, Yunnan Yunke Characteristic Plant Extraction Laboratory Co., Ltd.
Inventors:
Guanghui ZHANG, Chunli HUANG, Shengchao YANG, Bing HAO, Geng CHEN, Yanyu SHU, Zhiyuan LI, Xiaolin FENG, Simei HE, Yingchun LU