Patents by Inventor Guangliang Yu

Guangliang Yu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250213701
    Abstract: The present disclosure provides a proteolysis-targeting compound TPB-L-E3B, a method for synthesizing the same, and use thereof. The compound can treat human tumor diseases through the eRF3a-targeting proteolysis mechanism, and exhibits great potential in treating such diseases in in-vitro studies, particularly, in treating diseases such as prostate cancer, ovarian cancer, liver cancer, cervical cancer, leukemia, breast cancer, and the like.
    Type: Application
    Filed: March 20, 2025
    Publication date: July 3, 2025
    Inventors: Guangliang YU, Kai ZHONG, Yao CHEN, Liuquan HAN, Jiahui TIAN, Changzhou ZHANG, Zhenxing HU, Ping XU, Shujun MAO
  • Patent number: 8580997
    Abstract: Disclosed is a process for preparing single enantiomers of beta-amino phenylbutyric acid derivatives and pharmaceutically acceptable salts thereof, which affords the desired compounds having special optical configuration. The process comprises a step of chemical synthesis and a step of resolving the optical isomers of beta-amino phenylbutyric acid derivatives with a resolving agent. The resolving step comprises reacting the optical isomers with resolving agents, such as di-para-toluoyl-L-tartaric acid and di-para-toluoyl-D-tartaric acid. The obtained R-beta-amino phenylbutyric acid derivatives (I) have high optical purity, and the total yield of the accumulative resolution of the laevo and the dextro isomer is up to above 70%.
    Type: Grant
    Filed: April 14, 2009
    Date of Patent: November 12, 2013
    Assignee: Jiangsu Hengrui Medicine Co. Ltd.
    Inventors: Piaoyang Sun, Yongjiang Chen, Guangliang Yu
  • Patent number: 8541405
    Abstract: Methods for the preparation of Ivabradine sulfate and form I crystal thereof. In particular, the Ivabradine sulfate and the preparation methods thereof, and the stable form I crystal of Ivabradine sulfate and the preparation methods thereof.
    Type: Grant
    Filed: October 29, 2009
    Date of Patent: September 24, 2013
    Assignee: Jiangsu Hengrui Medicine Co., Ltd.
    Inventors: Piaoyang Sun, Yongjiang Chen, Guangliang Yu
  • Patent number: 8198485
    Abstract: A method of resolving an important chemical intermediate, 4,5-dimethoxy-1-(methylaminomethyl)-benzocyclobutane, comprises the following steps: reacting its two enantiomers of 4,5-dimethoxy-1-(methylaminomethyl)-benzocyclobutane with di-p-toluoyl-L-tartaric acid (LDTTA) or di-p-toluoyl-D-tartaric acid (DDTTA) in an alcoholic solution or an alcohol in water solution to give the corresponding salts, and then resolving the salts. This method gives high enantiomer excess value, high yield which is more than 80% in total with normal resolution and reverse resolution.
    Type: Grant
    Filed: October 10, 2008
    Date of Patent: June 12, 2012
    Assignee: Jiangsu Hengrui Medicine Co., Ltd.
    Inventors: Piaoyang Sun, Yongjiang Chen, Guangliang Yu
  • Publication number: 20110275614
    Abstract: Methods for the preparation of Ivabradine sulfate and form I crystal thereof. In particular, the Ivabradine sulfate and the preparation methods thereof, and the stable form I crystal of Ivabradine sulfate and the preparation methods thereof.
    Type: Application
    Filed: October 29, 2009
    Publication date: November 10, 2011
    Inventors: Piaoyang Sun, Yongjiang Chen, Guangliang Yu
  • Publication number: 20110130587
    Abstract: Disclosed is a process for preparing single enantiomers of beta-amino phenylbutyric acid derivatives and pharmaceutically acceptable salts thereof, which affords the desired compounds having special optical configuration. The process comprises a step of chemical synthesis and a step of resolving the optical isomers of beta-amino phenylbutyric acid derivatives with a resolving agent. The resolving step comprises reacting the optical isomers with resolving agents, such as di-para-toluoyl-L-tartaric acid and di-para-toluoyl-D-tartaric acid. The obtained R-beta-amino phenylbutyric acid derivatives (I) have high optical purity, and the total yield of the accumulative resolution of the laevo and the dextro isomer is up to above 70%.
    Type: Application
    Filed: April 14, 2009
    Publication date: June 2, 2011
    Applicant: Jiangsu Hengrui Medicine Co., Ltd.
    Inventors: Piaoyang Sun, Yongjiang Chen, Guangliang Yu