Patents by Inventor Guangmei Yang

Guangmei Yang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250026756
    Abstract: The present invention belongs to the field of medicinal chemistry, and particularly relates to synthesis, a preparation method and the use of an inhibitor containing dual targets SHP2 and CDK4/6, wherein the inhibitor comprises three compounds of general formulas I-III and pharmaceutically acceptable salts, enantiomers, diastereomers, tautomers, solvates, polymorphs or prodrugs thereof. According to the present invention, a class of brand-new SHP2 and CDK4/6 dual-target inhibitors are prepared by means of a pharmacophore fusion and reasonable drug design method, so that the problems of drug resistance, poor drug effect, etc., of the existing SHP2 inhibitor and CDK4/6 inhibitor are solved; the great significance of the present invention is providing the first SHP2 and CDK4/6 dual-target inhibitor, which provides a basis for solving the problem of drug resistance of kinase and phosphatase in the later period.
    Type: Application
    Filed: July 21, 2022
    Publication date: January 23, 2025
    Applicant: CHINA PHARMACEUTICAL UNIVERSITY
    Inventors: Xiaoxing WU, Xiaoyu CHEN, Wenqiang LI, Chengxia SHU, Guangmei LUO, Kexin YANG
  • Publication number: 20220053822
    Abstract: An aerosol generating product includes an aerosol atomizing element and a smoke cooling element, and the smoke cooling element is located downstream of the flow direction of the smoke generated by the aerosol atomizing element. A filter element is located downstream of the flow direction of the smoke through which the smoke cooling element passes; or a hollow element located upstream of the flow direction of the smoke through which the smoke cooling element passes. The smoke cooling element is composed of particles, and the structure includes a gap for smoke of a cigarette to pass through. The gap through which cigarette smoke can pass is a three-dimensional and non-linear gap. The structure is in the form of rods. When the smoke aerosol passes through the cooling element, ensuring the smoke to pass through smoothly.
    Type: Application
    Filed: August 31, 2021
    Publication date: February 24, 2022
    Inventors: Jianguo Cao, Zhanping Yang, Kai Su, Jianhua Cao, Tao Yu, Jianfeng Xia, Jianjun Miu, Jingjing Shen, Guangmei Yang, Paul Busby, Christopher Bundren, Michael Combs