Abstract: The present invention discloses a radioactive source delivery system and its method of use. The radioactive source delivery system comprise a radioactive source delivery mechanism connecting to the needle trocar via a flexible delivery tube, through which the radioactive source is implanted into a target body; and a needle pulling driver driving the flexible delivery tube which connects to the needle trocar inserted into the target body and controls the needle trocar to be pulled partly out of the target body, thereby adjusting the implantation position of the radioactive source.

Abstract: The present disclosure proposes a flexible delivery system and method for a radioactive source. The system includes a main body, a delivery channel, a flexible pushing wire, and a wire driving mechanism. The flexible pushing wire is disposed in the delivery channel, the delivery channel is configured to guide the flexible pushing wire to move forward and backward, the wire driving mechanism is capable of driving the flexible pushing wire to move reciprocally, and the flexible pushing wire is capable of driving seeds, or seed strain chains, or seed strand casings to a target position along the delivery channel, which can achieve high-precision positional control and implantation and solve the problem of drifting movement of the puncture needle and multi-channel implantation of radioactive sources.

Abstract: The invention discloses a radioactive source delivery system with a stylet pulling mechanism and its method of use. The wire driving mechanism is connected to the wire output channel, and the wire driving mechanism is used to drive the pushing wire to move back and forth along the wire output channel. A stylet pulling mechanism is located on one side of the front end of the wire output channel. Through the channel-switching mechanism, the wire output channel is docked with a flexible delivery tube. The front end of the flexible the delivery tube is connected to a puncture needle or has a quick connector for connecting to the puncture needle. The stylet pulling mechanism can dock with the tail portion of the flexible stylet inside the flexible delivery tube, pulling the flexible stylet out of the flexible delivery tube to form a hollow flexible delivery channel. A radioactive source feeding mechanism is used to place the radioactive source in front of the pushing wire.

Abstract: The present invention provides a method for synthesizing Milbemycin oxime. The method comprises the following steps. (1) Oxidizing reaction: oxidizing Milbemycin, using hypochlorite or chlorite as oxidizers and piperidine nitrogen oxygen free radicals as the catalyst and halide as the catalyst promoter. The oxidation reaction is conducted in a dichloromethane solvent for 0.5-4 hours at ?5-15° C. to produce the intermediate product Milbemycin ketone. (2) Oximation reaction: reacting the Milbemycin ketone with a hydroxylamine hydrochloride oximation agent in a 1,4-dioxane reaction solvent for 10-16 hours at 25-35° C. to obtain Milbemycin oxime. The method provided by the present invention realized the industrial production of Milbemycin oxime for the first time domestically. Moreover, the yield of the prepared product is higher than competing products both at home and abroad.

Abstract: The present invention provides a method for synthesizing Milbemycin oxime. The method comprises the following steps. (1) Oxidizing reaction: oxidizing Milbemycin, using hypochlorite or chlorite as oxidizers and piperidine nitrogen oxygen free radicals as the catalyst and halide as the catalyst promoter. The oxidation reaction is conducted in a dichloromethane solvent for 0.5-4 hours at ?5-15° C. to produce the intermediate product Milbemycin ketone. (2) Oximation reaction: reacting the Milbemycin ketone with a hydroxylamine hydrochloride oximation agent in a 1,4-dioxane reaction solvent for 10-16 hours at 25-35° C. to obtain Milbemycin oxime. The method provided by the present invention realized the industrial production of Milbemycin oxime for the first time domestically. Moreover, the yield of the prepared product is higher than competing products both at home and abroad.