Patents by Inventor Guangming Zhong

Guangming Zhong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TRK inhibitors useful as anticancer drugs
    Patent number: 11952364
    Abstract: A group of tropomyosin receptor kinase inhibitors including an amido-phenoxy-indazole structure fragment. These compounds show potent inhibitory effects on various oncogenic kinases, especially TRK, and thus can be used to treat tumors or cancers.
    Type: Grant
    Filed: September 3, 2019
    Date of Patent: April 9, 2024
    Assignee: TYLIGAND BIOSCIENCE (SHANGHAI) LIMITED
    Inventors: Boyu Zhong, Tony Yantao Zhang, Yiju Cao, Guangming Chen
  • Methods and compositions for attenuated chlamydia as vaccine and vector
    Patent number: 10596247
    Abstract: The present invention provides Chlamydia organisms and compositions and methods of use in the treatment/prevention of chlamydial infection in a subject, for eliciting an immune response in a subject and for use as vectors.
    Type: Grant
    Filed: February 19, 2016
    Date of Patent: March 24, 2020
    Assignee: Board of Regents, The University of Texas System
    Inventor: Guangming Zhong
  • METHODS AND COMPOSITIONS FOR ATTENUATED CHLAMYDIA AS VACCINE AND VECTOR
    Publication number: 20180021423
    Abstract: The present invention provides Chlamydia organisms and compositions and methods of use in the treatment/prevention of chlamydial infection in a subject, for eliciting an immune response in a subject and for use as vectors.
    Type: Application
    Filed: February 19, 2016
    Publication date: January 25, 2018
    Inventor: Guangming Zhong
  • Methods and compositions for chlamydial antigens for diagnosis and treatment of chlamydial infection and disease
    Patent number: 9068007
    Abstract: Disclosed are isolated Chlamydia trachomatis proteins, methods of fusion protein and associated antibody production, and methods of using isolated proteins and antibodies in diagnosis and detection. Also disclosed are compositions comprising isolated proteins, wherein the compositions can further comprising pharmaceutically acceptable carriers, an adjuvant and/or an immunostimulant, and methods using the pharmaceutical compositions for treating or preventing an infection by Chlamydia in a subject. The compositions may also comprise a protein or immunogenic fragment of a pathogenic organism other than Chlamydia trachomatis.
    Type: Grant
    Filed: October 9, 2009
    Date of Patent: June 30, 2015
    Assignee: Board of Regents, The University of Texas System
    Inventor: Guangming Zhong
  • Methods and compositions for chlamydial antigens as reagents for diagnosis of tubal factor infertility and chlamydial infection
    Patent number: 9046530
    Abstract: The present invention provides Chlamydia proteins and fragments thereof and methods of use in diagnostic assays.
    Type: Grant
    Filed: November 30, 2012
    Date of Patent: June 2, 2015
    Assignee: Board of Regents, The University of Texas System
    Inventor: Guangming Zhong
  • METHODS AND COMPOSITIONS FOR CHLAMYDIAL ANTIGENS AS REAGENTS/STRATEGIES FOR DIAGNOSIS AND TREATMENT OF CHLAMYDIAL INFECTION AND DISEASE
    Publication number: 20130251749
    Abstract: The present invention provides Chlamydia proteins and methods of use in diagnostic and detection assays as well as in treatment and immunization protocols.
    Type: Application
    Filed: May 13, 2013
    Publication date: September 26, 2013
    Inventor: Guangming Zhong
  • Methods and Compositions for Chlamydial Antigens as Reagents for Diagnosis of Tubal Factor Infertility and Chlamydial Infection
    Publication number: 20130143757
    Abstract: The present invention provides Chlamydia proteins and fragments thereof and methods of use in diagnostic assays.
    Type: Application
    Filed: November 30, 2012
    Publication date: June 6, 2013
    Applicant: Board of Regents, The University of Texas System
    Inventor: Guangming Zhong
  • Chlamydial antigens as reagents for diagnosis and treatment of chlamydial infection and disease
    Patent number: 8440208
    Abstract: The present invention provides Chlamydia proteins and methods of use in diagnostic and detection assays as well as in treatment and immunization protocols.
    Type: Grant
    Filed: May 1, 2008
    Date of Patent: May 14, 2013
    Assignee: Board of Regents, The University of Texas System
    Inventor: Guangming Zhong
  • Methods and Compositions for Chlamydial Antigens for Diagnosis and Treatment of Chlamydial Infection and Disease
    Publication number: 20130045181
    Abstract: The present invention provides Chlamydia proteins and methods of use in treatment and immunization protocols as well as in diagnostic and detection assays.
    Type: Application
    Filed: March 9, 2011
    Publication date: February 21, 2013
    Inventor: Guangming Zhong
  • Methods and compositions for immunization against chlamydial infection and disease
    Patent number: 8092812
    Abstract: The present invention provides Chlamydia proteins and compositions and methods of use in the treatment/prevention of chlamydial infection in a subject, for eliciting an immune response in a subject and for reducing the likelihood of infertility and reducing the incidence and/or degree of hydrosalpinx due to Chlamydia infection in a subject.
    Type: Grant
    Filed: December 17, 2010
    Date of Patent: January 10, 2012
    Assignee: Board of Regents, The University of Texas System
    Inventors: Bernard P. Arulanandam, Ashlesh K. Murthy, Guangming Zhong
  • Methods and Compositions for Chlamydial Antigens for Diagnosis and Treatment of Chlamydial Infection and Disease
    Publication number: 20110256094
    Abstract: Disclosed are isolated Chlamydia trachomatis proteins, methods of fusion protein and associated antibody production, and methods of using isolated proteins and antibodies in diagnosis and detection. Also disclosed are compositions comprising isolated proteins, wherein the compositions can further comprising pharmaceutically acceptable carriers, an adjuvant and/or an immunostimulant, and methods using the pharmaceutical compositions for treating or preventing an infection by Chlamydia in a subject. The compositions may also comprise a protein or immunogenic fragment of a pathogenic organism other than Chlamydia trachomatis.
    Type: Application
    Filed: October 9, 2009
    Publication date: October 20, 2011
    Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM
    Inventor: Guangming Zhong
  • METHODS AND COMPOSITIONS FOR IMMUNIZATION AGAINST CHLAMYDIAL INFECTION AND DISEASE
    Publication number: 20110123491
    Abstract: The present invention provides Chlamydia proteins and compositions and methods of use in the treatment/prevention of chlamydial infection in a subject, for eliciting an immune response in a subject and for reducing the likelihood of infertility and reducing the incidence and/or degree of hydrosalpinx due to Chlamydia infection in a subject.
    Type: Application
    Filed: December 17, 2010
    Publication date: May 26, 2011
    Inventors: Bernard P. Arulanandam, Ashlesh K. Murthy, Guangming Zhong
  • Methods and compositions for immunization against chlamydial infection and disease
    Patent number: 7892567
    Abstract: The present invention provides Chlamydia proteins and compositions and methods of use in the treatment/prevention of chlamydial infection in a subject, for eliciting an immune response in a subject and for reducing the likelihood of infertility and reducing the incidence and/or degree of hydrosalpinx due to Chlamydia infection in a subject.
    Type: Grant
    Filed: October 1, 2008
    Date of Patent: February 22, 2011
    Assignee: Board of Regents, The University of Texas System
    Inventors: Bernard P. Arulanandam, Ashlesh K. Murthy, Guangming Zhong
  • CHLAMYDIAL ANTIGENS AS REAGENTS FOR DIAGNOSIS AND TREATMENT OF CHLAMYDIAL INFECTION AND DISEASE
    Publication number: 20100119549
    Abstract: The present invention provides Chlamydia proteins and methods of use in diagnostic and detection assays as well as in treatment and immunization protocols.
    Type: Application
    Filed: May 1, 2008
    Publication date: May 13, 2010
    Inventor: Guangming Zhong
  • METHODS AND COMPOSITIONS FOR IMMUNIZATION AGAINST CHLAMYDIAL INFECTION AND DISEASE
    Publication number: 20090098165
    Abstract: The present invention provides Chlamydia proteins and compositions and methods of use in the treatment/prevention of chlamydial infection in a subject, for eliciting an immune response in a subject and for reducing the likelihood of infertility and reducing the incidence and/or degree of hydrosalpinx due to Chlamydia infection in a subject.
    Type: Application
    Filed: October 1, 2008
    Publication date: April 16, 2009
    Inventors: Bernard P. Arulanandam, Ashlesh K. Murthy, Guangming Zhong