Patents by Inventor Guangshan Li

Guangshan Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20120244568
    Abstract: A label-free cell assay method including: culturing rigid cells in a buffer, the rigid cells having a diameter of about 3 to about 7 micrometers; depositing the rigid cells on the surface of a sensor system; and detecting the rigid cells with the sensor when exposed to two or more wavelengths of light having two or more penetration depths, as defined herein. Also disclosed are assay methods for contacting the rigid cells with a substance and determining the response of the contacted rigid cells to the substance, such as a drug candidate or modulator compound, as defined herein.
    Type: Application
    Filed: January 25, 2012
    Publication date: September 27, 2012
    Inventors: Fang Lai, Guangshan Li, Anping Liu, Jinlin Peng
  • Patent number: 8243276
    Abstract: A surface plasmon resonance sensor system including a high refractive index prism, a sensor chip, a light source having multiple wavelengths over a broad range of wavelengths, optical lenses, a photodetector, a data acquisition unit, and as defined herein. The sensor chip can include, for example, a thin layer of silicon and gold on one face of a transparent substrate and the prism adjacent to the opposite face of the transparent substrate. Such an arrangement provides variable penetration depths up to about 1.5 micrometers with a dynamic range for sensing index of refraction changes in a sample that are several times greater than that of a conventional SPR sensor. The disclosure provides methods for using the surface plasmon resonance sensor system for cell assay or chemical assay related applications.
    Type: Grant
    Filed: November 30, 2009
    Date of Patent: August 14, 2012
    Assignee: Corning Incorporated
    Inventors: James Gregory Couillard, Norman Henry Fontaine, Guangshan Li, Anping Liu, Jinlin Peng, Donnell Thaddeus Walton
  • Publication number: 20120133943
    Abstract: Systems and methods for sensing a surface plasmon resonance (SPR) biosensor using two or more wavelengths and with reduced chromatic aberration are disclosed. The system includes a beam-forming optical system that has chromatic aberration at the two or more wavelengths. A light source system provides respectively light of the two or more wavelengths, with light of each wavelength provided from a different distance from the beam-forming optical system. The different distances are selected to reduce or eliminate adverse effects of chromatic aberration on the formation of a focus spot on the SPR biosensor chip. An illumination system for illuminating a SPR biosensor using different light having different wavelengths is also disclosed.
    Type: Application
    Filed: November 29, 2010
    Publication date: May 31, 2012
    Inventors: Norman Henry Fontaine, Guangshan Li, Anping Liu, Jinlin Peng
  • Patent number: 8163561
    Abstract: A surface plasmon resonance sensor system including a high refractive index prism, a sensor chip, a light source having multiple wavelengths over a broad range of wavelengths, optical lenses, a photodetector, a data acquisition unit, and as defined herein. The sensor chip can include, for example, a thin layer of silicon and gold on one face of a transparent substrate and the prism adjacent to the opposite face of the transparent substrate. Such an arrangement provides variable penetration depths up to about 1.5 micrometers with a dynamic range for sensing index of refraction changes in a sample that are several times greater than that of a conventional SPR sensor. The disclosure provides methods for using the surface plasmon resonance sensor system for cell assay or chemical assay related applications.
    Type: Grant
    Filed: November 30, 2009
    Date of Patent: April 24, 2012
    Assignee: Corning Incorporated
    Inventors: Norman Henry Fontaine, Joydeep Lahiri, Guangshan Li, Anping Liu, Jinlin Peng
  • Publication number: 20110171746
    Abstract: A surface plasmon resonance sensor system including a high refractive index prism, a sensor chip, a light source having multiple wavelengths over a broad range of wavelengths, optical lenses, a photodetector, a data acquisition unit, and as defined herein. The sensor chip can include, for example, a thin layer of silicon and gold on one face of a transparent substrate and the prism adjacent to the opposite face of the transparent substrate. Such an arrangement provides variable penetration depths up to about 1.5 micrometers with a dynamic range for sensing index of refraction changes in a sample that are several times greater than that of a conventional SPR sensor. The disclosure provides methods for using the surface plasmon resonance sensor system for cell assay or chemical assay related applications.
    Type: Application
    Filed: November 30, 2009
    Publication date: July 14, 2011
    Inventors: Norman Henry Fontaine, Joydeep Lahiri, Guangshan Li, Anping Liu, Jinlin Peng
  • Publication number: 20110128546
    Abstract: A surface plasmon resonance sensor system including a high refractive index prism, a sensor chip, a light source having multiple wavelengths over a broad range of wavelengths, optical lenses, a photodetector, a data acquisition unit, and as defined herein. The sensor chip can include, for example, a thin layer of silicon and gold on one face of a transparent substrate and the prism adjacent to the opposite face of the transparent substrate. Such an arrangement provides variable penetration depths up to about 1.5 micrometers with a dynamic range for sensing index of refraction changes in a sample that are several times greater than that of a conventional SPR sensor. The disclosure provides methods for using the surface plasmon resonance sensor system for cell assay or chemical assay related applications.
    Type: Application
    Filed: November 30, 2009
    Publication date: June 2, 2011
    Inventors: James Gregory Couillard, Norman Henry Fontaine, Guangshan Li, Anping Liu, Jinlin Peng, Donnell Thaddeus Walton
  • Publication number: 20090181409
    Abstract: An apparatus and non-invasive method to measure cell-cell interactions, such as T-cell and stem cell interactions, under physiologically relevant conditions, and optionally measure the effects of stimuli on the cell-cell interactions, as defined herein.
    Type: Application
    Filed: January 10, 2008
    Publication date: July 16, 2009
    Inventors: Ye Fang, Guangshan Li
  • Patent number: 7364849
    Abstract: A method of treating a substrate for immobilizing a biomolecule and substrates produced by the method are disclosed. The method includes contacting at least a portion of a substrate with a reducing agent such as a hydride. Treatment with an appropriate reducing agent substantially eliminates autofluorescence on substrates.
    Type: Grant
    Filed: December 5, 2003
    Date of Patent: April 29, 2008
    Assignee: Corning Incorporated
    Inventors: Yijia Bao, Guangshan Li, Nalini Raghavachari, Mingqian He, Xinying Xie, Yuming Xie
  • Publication number: 20070048747
    Abstract: Described herein are methods for assaying analytes.
    Type: Application
    Filed: September 1, 2005
    Publication date: March 1, 2007
    Inventors: Thomas Leslie, Guangshan Li, Jeffrey Lynn, Jinlin Peng
  • Patent number: 7141374
    Abstract: A method of treating a substrate for immobilizing a biomolecule and substrates produced by the method are disclosed. The method includes contacting at least a portion of a substrate with a reducing agent such as a hydride. Treatment with an appropriate reducing agent substantially eliminates autofluorescence on substrates.
    Type: Grant
    Filed: December 5, 2003
    Date of Patent: November 28, 2006
    Assignee: Corning Incorporated
    Inventors: Yijia Bao, Guangshan Li, Nalini Raghavachari, Mingqian He, Xinying Xie, Yuming Xie
  • Patent number: 6787312
    Abstract: A method of treating a substrate for immobilizing a biomolecule and substrates produced by the method are disclosed. The method includes contacting at least a portion of a substrate with a reducing agent such as a hydride. Treatment with an appropriate reducing agent substantially eliminates autofluorescence on substrates.
    Type: Grant
    Filed: August 9, 2001
    Date of Patent: September 7, 2004
    Assignee: Corning Incorporated
    Inventors: Yijia Bao, Guangshan Li, Nalini Raghavachari, Mingqian He, Xinying Xie, Yuming Xie
  • Publication number: 20040142365
    Abstract: A method of treating a substrate for immobilizing a biomolecule and substrates produced by the method are disclosed. The method includes contacting at least a portion of a substrate with a reducing agent such as a hydride. Treatment with an appropriate reducing agent substantially eliminates autofluorescence on substrates.
    Type: Application
    Filed: December 5, 2003
    Publication date: July 22, 2004
    Inventors: Yijia Bao, Guangshan Li, Nalini Raghavachari, Mingqian He, Xinying Xie, Yuming Xie
  • Publication number: 20040121391
    Abstract: A method of treating a substrate for immobilizing a biomolecule and substrates produced by the method are disclosed. The method includes contacting at least a portion of a substrate with a reducing agent such as a hydride. Treatment with an appropriate reducing agent substantially eliminates autofluorescence on substrates.
    Type: Application
    Filed: December 5, 2003
    Publication date: June 24, 2004
    Inventors: Yijia Bao, Guangshan Li, Nalini Raghavachari, Mingqian He, Xinying Xie, Yuming Xie
  • Publication number: 20030082618
    Abstract: Methods and DNA microarray devices for detecting or measuring genetic aberrations or changes in genomic DNA using comparative genomic hybridization (CGH) techniques and gene-expression assays are provided.
    Type: Application
    Filed: October 15, 2002
    Publication date: May 1, 2003
    Inventors: Guangshan Li, Uwe R. Muller, Yijia Bao, Xinying Xie, Nalini Raghavachari
  • Publication number: 20030036062
    Abstract: A method of treating a substrate for immobilizing a biomolecule and substrates produced by the method are disclosed. The method includes contacting at least a portion of a substrate with a reducing agent such as a hydride. Treatment with an appropriate reducing agent substantially eliminates autofluorescence on substrates.
    Type: Application
    Filed: August 9, 2001
    Publication date: February 20, 2003
    Inventors: Yijia Bao, Guangshan Li, Nalini Raghavachari, Mingqian He, Xinying Xie, Yuming Xie