Abstract: The present disclosure relates to the technical field of medicines, and in particular, to a composite scaffold material, a preparation method therefor and use thereof. The present disclosure provides a composite scaffold material, including a charged fiber framework material. The fiber framework material is coated with positively charged biocompatible materials and negatively charged biocompatible materials alternately, by means of electrostatic attraction. The composite scaffold material of the present disclosure overcomes the defects of traditional scaffold materials, such as poor hydrophilicity, biocompatibility, histiocyte adhesion ability, and biological induction activity. The composite scaffold material has better applicability when used for tissue adhesion, closure, leaking stoppage, hemostasis, isolation, repair, and adhesion prevention, and can also be used for preparing a drug carrier (e.g., sustained release carrier) and a tissue engineering scaffold material.

Abstract: The present invention provides a drug-loaded tissue adhesive film, comprising alternately superposed cationic layers and anionic layers, at least one of the cationic layers and the anionic layers being a drug layer, or at least one of the cationic layers and the anionic layers containing a drug with charges. The provided drug-loaded tissue adhesive film has good tissue adhesiveness, biocompatibility, degradable absorption, and stability, and the physical and chemical properties of the drug-loaded tissue adhesive film can be adjusted by adjusting material compositions.