Patents by Inventor Guangxiu Dai

Guangxiu Dai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Certain triazolopyridines and triazolopyrazines, compositions thereof and methods of use therefor
    Patent number: 11896592
    Abstract: Provided are certain triazolopyridines and triazolopyrazines of Formula 1, wherein X, Y, R1, R2, R3, R4 and R5 have any of the meanings described herein; processes for their preparation, pharmaceutical compositions containing them, and their use in the treatment of cell proliferative disorders.
    Type: Grant
    Filed: February 3, 2021
    Date of Patent: February 13, 2024
    Assignee: Hutchison Medipharma Limited
    Inventors: Wei-Guo Su, Hong Jia, Guangxiu Dai
  • HETEROARYL HETEROCYCLIC COMPOUNDS AND USES THEREOF
    Publication number: 20230382916
    Abstract: The present invention relates to heteroaryl heterocyclic compounds of formula (I), pharmaceutical compositions comprising same, methods for preparing same, and uses thereof, wherein the variables are as defined in the description.
    Type: Application
    Filed: April 17, 2023
    Publication date: November 30, 2023
    Inventors: Guangxiu DAI, Kun XIAO
  • Substituted piperazines as BTK inhibitors
    Patent number: 11655254
    Abstract: Provided are heteroaryl heterocyclic compounds of formula (I), pharmaceutical compositions comprising same, methods for preparing same, and uses thereof, wherein the variables are as defined in the description. The compounds are Btk inhibitors.
    Type: Grant
    Filed: April 25, 2022
    Date of Patent: May 23, 2023
    Assignee: HUTCHISON MEDIPHARMA LIMITED
    Inventors: Guangxiu Dai, Kun Xiao
  • HETEROARYL HETEROCYCLIC COMPOUNDS AND USES THEREOF
    Publication number: 20230043030
    Abstract: The present invention relates to heteroaryl heterocyclic compounds, e.g., the compound of the formula shown below, pharmaceutical compositions comprising same, methods for preparing same, and uses thereof.
    Type: Application
    Filed: August 31, 2022
    Publication date: February 9, 2023
    Inventors: Guangxiu DAI, Kun XIAO
  • CYCLOOLEFIN SUBSTITUTED HETEROAROMATIC COMPOUNDS AND THEIR USE
    Publication number: 20220372005
    Abstract: Compounds of formula (I) or a pharmaceutically acceptable salt thereof, and/or solvates racemic mixtures, enantiomers, diasteromers, and tautomers thereof, wherein A, R1, R2, R3, R3?, R4, R4?, R5, R6, R7, R8, m, and n are as defined in the detailed description.
    Type: Application
    Filed: May 18, 2022
    Publication date: November 24, 2022
    Applicant: HUTCHISON MEDIPHARMA LIMITED
    Inventors: Wei-Guo SU, Guangxiu DAI, Kun XIAO
  • 2-(3?-(hydroxymethyl)-1-methyl-5-((5-(2-methyl-4-(oxetan-3-yl)piperazin-1-yl)pyridin-2-yl)amino)-6-oxo-1,6-dihydro-[3,4?-bipyridin]-2?-yl)-7,7-dimethyl-7,8-dihydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one as a BTK inhibitor
    Patent number: 11478474
    Abstract: The present invention relates to heteroaryl heterocyclic compounds, e.g., the compound of the formula shown below, pharmaceutical compositions comprising same, methods for preparing same, and uses thereof.
    Type: Grant
    Filed: October 20, 2021
    Date of Patent: October 25, 2022
    Assignee: HUTCHISON MEDIPHARMA LIMITED
    Inventors: Guangxiu Dai, Kun Xiao
  • HETEROARYL HETEROCYCLIC COMPOUNDS AND USES THEREOF
    Publication number: 20220332719
    Abstract: Provided are heteroaryl heterocyclic compounds of formula (I), pharmaceutical compositions comprising same, methods for preparing same, and uses thereof, wherein the variables are as defined in the description. The compounds are Btk inhibitors.
    Type: Application
    Filed: April 25, 2022
    Publication date: October 20, 2022
    Inventors: Guangxiu DAI, Kun XIAO
  • Cycloolefin substituted heteroaromatic compounds and their use
    Patent number: 11414390
    Abstract: Compounds of formula (I) or a pharmaceutically acceptable salt thereof, and/or solvates, racemic mixtures, enantiomers, diasteromers, and tautomers thereof, wherein A, R1, R2, R3, R3?, R4, R4?, R5, R6, R7, R8, m, and n are as defined in the detailed description.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: August 16, 2022
    Assignee: Hutchison Medipharma Limited
    Inventors: Wei-Guo Su, Guangxiu Dai, Kun Xiao
  • HETEROARYL HETEROCYCLIC COMPOUNDS AND USES THEREOF
    Publication number: 20220125785
    Abstract: The present invention belongs to the pharmaceutical field, and provides crystalline forms, solvates and the crystalline forms thereof of the compound (S)-4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]pyridazin-7-yl)ethyl)amino)pyrimidine-5-carbo nitrile, and the pharmaceutical compositions comprising the same as well as the methods of preparing the same and the use thereof.
    Type: Application
    Filed: October 20, 2021
    Publication date: April 28, 2022
    Inventors: Guangxiu DAI, Kun XIAO
  • CYCLOOLEFIN SUBSTITUTED HETEROAROMATIC COMPOUNDS AND THEIR USE
    Publication number: 20210363115
    Abstract: The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof, and/or solvates, racemic mixtures, enantiomers, diasteromers, and tautomers thereof, wherein A, R1, R2, R3, R3?, R4, R4?, R5, R6, R7, R8, m, and n are as defined in the detailed description of the invention.
    Type: Application
    Filed: September 7, 2018
    Publication date: November 25, 2021
    Applicant: Hutchison Medipharma Limited
    Inventors: Wei-Guo Su, Guangxiu Dai, Kun Xiao
  • CYCLOOLEFIN SUBSTITUTED HETEROAROMATIC COMPOUNDS AND THEIR USE
    Publication number: 20210163426
    Abstract: Compounds of formula (I) or a pharmaceutically acceptable salt thereof, and/or solvates, racemic mixtures, enantiomers, diasteromers, and tautomers thereof, wherein A, R1, R2, R3, R3?, R4, R4?, R5, R6, R7, R8, m, and n are as defined in the detailed description.
    Type: Application
    Filed: September 7, 2018
    Publication date: June 3, 2021
    Inventors: Wei-Guo Su, Guangxiu Dai, Kun Xiao
  • CERTAIN TRIAZOLOPYRIDINES AND TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR
    Publication number: 20210154192
    Abstract: Provided are certain triazolopyridines and triazolopyrazines, compositions thereof and methods of use therefor.
    Type: Application
    Filed: February 3, 2021
    Publication date: May 27, 2021
    Applicant: Hutchison Medipharma Limited
    Inventors: Wei-Guo Su, Hong Jia, Guangxiu Dai
  • Certain triazolopyridines and triazolopyrazines, compositions thereof and methods of use therefor
    Patent number: 10946014
    Abstract: Provided are certain triazolopyridines and triazolopyrazines, compositions thereof and methods of use therefor.
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: March 16, 2021
    Assignee: Hutchison Medipharma Limited
    Inventors: Wei-Guo Su, Hong Jia, Guangxiu Dai
  • CERTAIN TRIAZOLOPYRIDINES AND TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR
    Publication number: 20200179377
    Abstract: Provided are certain triazolopyridines and triazolopyrazines, compositions thereof and methods of use therefor.
    Type: Application
    Filed: November 8, 2019
    Publication date: June 11, 2020
    Applicant: Hutchison Medipharma Limited
    Inventors: Guangxiu Dai, Hong Jia, Wei-Guo Su
  • Imidazopyridazine compounds and their use
    Patent number: 10611777
    Abstract: This disclosure provides novel imidazopyridazine compounds of formula (I) and pharmaceutical acceptable salt thereof, pharmaceutical compositions containing them, a process for preparing them, and their practical effect in inhibiting PI3K and potential use in treating a disease responsive to inhibition of PI3K, for example, an inflammatory disease, autoimmune disease or cancer.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: April 7, 2020
    Assignee: HUTCHISON MEDIPHARMA LIMITED
    Inventors: Wei-Guo Su, Guangxiu Dai, Weihan Zhang, Wei Deng
  • Certain triazolopyridines and triazolopyrazines, compositions thereof and methods of use therefor
    Patent number: 10512645
    Abstract: Provided are certain triazolopyridines and triazolopyrazines, compositions thereof and methods of use therefor.
    Type: Grant
    Filed: April 4, 2018
    Date of Patent: December 24, 2019
    Assignee: Hutchinson Medipharma Limited
    Inventors: Wei-Guo Su, Hong Jia, Guangxiu Dai
  • NOVEL IMIDAZOPYRIDAZINE COMPOUNDS AND THEIR USE
    Publication number: 20190127391
    Abstract: This disclosure provides novel imidazopyridazine compounds of formula (I) and pharmaceutical acceptable salt thereof, pharmaceutical compositions containing them, a process for preparing them, and their practical effect in inhibiting PI3K and potential use in treating a disease responsive to inhibition of PI3K, for example, an inflammatory disease, autoimmune disease or cancer.
    Type: Application
    Filed: December 20, 2018
    Publication date: May 2, 2019
    Inventors: Wei-Guo Su, Guangxiu Dai, Weihan Zhang, Wei Deng
  • Imidazopyridazine compounds and their use
    Patent number: 10208066
    Abstract: This disclosure provides novel imidazopyridazine compounds of formula (I) and pharmaceutical acceptable salt thereof, pharmaceutical compositions containing them, a process for preparing them, and their practical effect in inhibiting PI3K and potential use in treating a disease responsive to inhibition of PI3K, for example, an inflammatory disease, autoimmune disease or cancer.
    Type: Grant
    Filed: September 23, 2015
    Date of Patent: February 19, 2019
    Assignee: HUTCHISON MEDIPHARMA LIMITED
    Inventors: Wei-Guo Su, Guangxiu Dai, Welhan Zhang, Wei Deng
  • CERTAIN TRIAZOLOPYRIDINES AND TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR
    Publication number: 20180263977
    Abstract: Provided are certain triazolopyridines and triazolopyrazines, compositions thereof and methods of use therefor.
    Type: Application
    Filed: April 4, 2018
    Publication date: September 20, 2018
    Applicant: Hutchison Medipharma Limited
    Inventors: Wei-Guo Su, Hong Jia, Guangxiu Dai
  • Certain triazolopyridines and triazolopyrazines, compositions thereof and methods of use therefor
    Patent number: 9956218
    Abstract: Provided are certain triazolopyridines and triazolopyrazines, compositions thereof and methods of use therefor.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: May 1, 2018
    Assignee: Hutchison Medipharma Limited
    Inventors: Wei-Guo Su, Hong Jia, Guangxiu Dai