Abstract: Disclosed are a novel tetrahydroisoquinoline compound, a method for preparing intermediates thereof, a pharmaceutical composition thereof and the use thereof. The tetrahydroisoquinoline compound of the present invention has a good inhibitory effect on phosphodiesterase (PDE4), and can be used in the prevention, treatment or auxiliary treatment of multiple diseases associated with the activity or expression of phosphodiesterase, especially PDE4-associated immune and inflammatory diseases, such as psoriasis and arthritis.

Abstract: A receiver, a receiver assembly and a heat pump system. The receiver includes a first pipe, a second pipe and a third pipe leading to the cavity of the receiver, wherein the first pipe, the second pipe and the third pipe connect to a first load unit, a second load unit and a cold and heat source unit, respectively.

Abstract: A heat pump system, a defrosting method for the heat pump system, and a controller. The heat pump system includes a heat exchanger assembly for exchanging heat with a fluid medium, the heat exchanger assembly comprised a first heat exchanger and a second heat exchanger arranged in parallel, the second heat exchanger being arranged upstream of the first heat exchanger in the flow direction of the fluid medium, and when the heat pump system is operating in a heating mode and the temperature and/or ambient humidity to which the heat exchanger assembly is currently exposed reach a pre-set value, the second heat exchanger and the first heat exchanger function as a condenser and an evaporator, respectively.

Abstract: A method for dynamic state estimation (DSE) in a power distribution system (PDS) determines a new state of the PDS from a current state of the PDS via an indirect state transition model defining a transition of the current state of the PDS to the new state of the PDS through a transition of a current power injection to a new power injection on each bus of the PDS. The method measures one or combination of power flows, power injections, voltage magnitudes and phase angles on the measuring buses in the PDS and updates the new state of the PDS based on corresponding differences between one or combination of the estimated power flows, the estimated power injections, the estimated voltage magnitudes and the estimated phase angles with the measured power flows, the measured power injections, the measured voltage magnitudes and the measured phase angles.

Abstract: A method for dynamic state estimation (DSE) in a power distribution system (PDS) determines a new state of the PDS from a current state of the PDS via an indirect state transition model defining a transition of the current state of the PDS to the new state of the PDS through a transition of a current power injection to a new power injection on each bus of the PDS. The method measures one or combination of power flows, power injections, voltage magnitudes and phase angles on the measuring buses in the PDS and updates the new state of the PDS based on corresponding differences between one or combination of the estimated power flows, the estimated power injections, the estimated voltage magnitudes and the estimated phase angles with the measured power flows, the measured power injections, the measured voltage magnitudes and the measured phase angles.