Patents by Inventor Guanli Wu

Guanli Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20100254904
    Abstract: Targeted therapeutic delivery systems comprising gas- or gaseous precursor-filled lipid microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic delivery applications are also provided. Targeted therapeutic delivery systems comprising gas- or gaseous precursor-filled liposomes having a drug encapsulated therein are preferred. Methods of and apparatus for preparing such liposomes and methods for employing such liposomes in therapeutic delivery applications are also disclosed.
    Type: Application
    Filed: August 1, 2006
    Publication date: October 7, 2010
    Inventors: Evan C. Unger, Thomas A. Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu
  • Patent number: 7083572
    Abstract: Targeted therapeutic delivery systems comprising gas- or gaseous precursor-filled lipid microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic delivery applications are also provided. Targeted therapeutic delivery systems comprising gas- or gaseous precursor-filled liposomes having a drug encapsulated therein are preferred. Methods of and apparatus for preparing such liposomes and methods for employing such liposomes in therapeutic delivery applications are also disclosed.
    Type: Grant
    Filed: March 26, 2002
    Date of Patent: August 1, 2006
    Assignee: Bristol-Myers Squibb Medical Imaging, Inc.
    Inventors: Evan C. Unger, Thomas A. Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu
  • Publication number: 20050163716
    Abstract: Methods of and apparatus for preparing gas-filled microspheres are described. Gas-filled microspheres prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
    Type: Application
    Filed: January 14, 2005
    Publication date: July 28, 2005
    Inventors: Evan Unger, Thomas Fritz, Terry Matsunaga, Varadarajan Ramaswami, David Yellowhair, Guanli Wu
  • Publication number: 20030039613
    Abstract: Targeted therapeutic delivery systems comprising gas- or gaseous precursor-filled lipid microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic delivery applications are also provided.
    Type: Application
    Filed: March 26, 2002
    Publication date: February 27, 2003
    Inventors: Evan C. Unger, Thomas A. Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu
  • Publication number: 20030003055
    Abstract: Methods of and apparatus for preparing gas-filled microspheres are described. Gas-filled microspheres prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
    Type: Application
    Filed: August 6, 2002
    Publication date: January 2, 2003
    Inventors: Evan C. Unger, Thomas A. Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu
  • Patent number: 6479034
    Abstract: Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
    Type: Grant
    Filed: July 17, 1998
    Date of Patent: November 12, 2002
    Assignee: Bristol-Myers Squibb Medical Imaging, Inc.
    Inventors: Evan C. Unger, Thomas A. Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu
  • Patent number: 6443898
    Abstract: Therapeutic delivery systems comprising gaseous precursor-filled microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic delivery applications are also provided. Therapeutic delivery systems comprising gaseous precursor-filled liposomes having encapsulated therein a contrast agent or drug are preferred. Methods of and apparatus for preparing such liposomes and methods for employing such liposomes in therapeutic delivery applications are also disclosed.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 3, 2002
    Assignee: Imarx Pharmaceutical Corp.
    Inventors: Evan C. Unger, Thomas A. Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu
  • Patent number: 6414139
    Abstract: Novel silicon amphiphilic compounds which comprise a silicon residue. The silicon amphiphilic compounds are particularly suitable for use in compositions for diagnostic imaging, such as ultrasound. Compositions of the silicon amphiphilic compounds comprise a gas or gaseous precursor, and may take the form of vesicle compositions, such as micelles or liposomes.
    Type: Grant
    Filed: September 3, 1996
    Date of Patent: July 2, 2002
    Assignee: Imarx Therapeutics, Inc.
    Inventors: Evan C. Unger, Dekang Shen, Guanli Wu
  • Publication number: 20010044583
    Abstract: Contrast agents for ultrasonic imaging comprising gas filled liposomes prepared using vacuum drying gas instillation methods, and gas filled liposomes substantially devoid of liquid in the interior thereof, are described. Methods of and apparatus for preparing such liposomes and methods for employing such liposomes in ultrasonic imaging applications are also disclosed. Also described are diagnostic kits for ultrasonic imaging which include the subject contrast agents.
    Type: Application
    Filed: July 10, 2001
    Publication date: November 22, 2001
    Inventors: Evan C. Unger, Guanli Wu
  • Publication number: 20010025144
    Abstract: Contrast agents for ultrasonic imaging comprising gas filled liposomes prepared using vacuum drying gas instillation methods, and gas filled liposomes substantially devoid of liquid in the interior thereof, are described. Methods of and apparatus for preparing such liposomes and methods for employing such liposomes in ultrasonic imaging applications are also disclosed. Also described are diagnostic kits for ultrasonic imaging which include the subject contrast agents.
    Type: Application
    Filed: December 30, 1997
    Publication date: September 27, 2001
    Inventors: EVAN C. UNGER, GUANLI WU
  • Patent number: 6071495
    Abstract: Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
    Type: Grant
    Filed: October 2, 1997
    Date of Patent: June 6, 2000
    Assignee: ImaRx Pharmaceutical Corp.
    Inventors: Evan C. Unger, Thomas A. Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu
  • Patent number: 6056938
    Abstract: Cationic lipid compounds which comprise at least two cationic groups. The cationic lipid compounds are particularly suitable for use as carriers in the intracellular delivery of bioactive agents, including pharmaceuticals and genetic material. Compositions of the present cationic lipid compounds include suspensions, emulsions, micelles and liposomes.
    Type: Grant
    Filed: May 5, 1998
    Date of Patent: May 2, 2000
    Assignee: Imarx Pharaceutical Corp.
    Inventors: Evan C. Unger, Dekang Shen, Guanli Wu
  • Patent number: 6033646
    Abstract: Lyophilized lipid compositions, as well as methods for their preparation, are embodied by the present invention. Gas-filled microspheres prepared using the lyophilized lipid composition are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
    Type: Grant
    Filed: February 19, 1998
    Date of Patent: March 7, 2000
    Assignee: ImaRx Pharmaceutical Corp.
    Inventors: Evan C. Unger, Thomas A. Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu
  • Patent number: 5948387
    Abstract: Novel contrast media for use in ultrasonic imaging are described. Such contrast media may be comprised of an aqueous solution of one or more biocompatible polymers, wherein said biocompatible polymers are coated with and/or in admixture with at least one silicon containing compound. Alternatively, the contrast media may be comprised of an aqueous solution of one or more biocompatible synthetic polymers, or an aqueous solution of cellulose. The contrast media may be employed, if desired, with anti-gas agents and/or suspending agents.
    Type: Grant
    Filed: May 9, 1997
    Date of Patent: September 7, 1999
    Assignee: Imarx Pharmaceutical Corp.
    Inventors: Evan C. Unger, Guanli Wu
  • Patent number: 5935553
    Abstract: Methods of and apparatus for preparing gas-filled liposomes are described. Gas-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
    Type: Grant
    Filed: November 25, 1996
    Date of Patent: August 10, 1999
    Assignee: ImaRx Pharmaceutical Corp.
    Inventors: Evan C. Unger, Thomas A. Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu
  • Patent number: 5853752
    Abstract: Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: December 29, 1998
    Assignee: ImaRx Pharmaceutical Corp.
    Inventors: Evan C. Unger, Thomas A. Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu
  • Patent number: 5830430
    Abstract: Cationic lipid compounds which comprise at least two cationic groups. The cationic lipid compounds are particularly suitable for use as carriers in the intracellular delivery of bioactive agents, including pharmaceuticals and genetic material. Compositions of the present cationic lipid compounds include suspensions, emulsions, micelles and liposomes.
    Type: Grant
    Filed: February 21, 1995
    Date of Patent: November 3, 1998
    Assignee: ImaRx Pharmaceutical Corp.
    Inventors: Evan C. Unger, Dekang Shen, Guanli Wu
  • Patent number: 5776429
    Abstract: Lyophilized lipid compositions, as well as methods for their preparation, are embodied by the present invention. Gas-filled microspheres prepared using the lyophilized lipid composition are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
    Type: Grant
    Filed: April 30, 1996
    Date of Patent: July 7, 1998
    Assignee: ImaRx Pharmaceutical Corp.
    Inventors: Evan C. Unger, Thomas A. Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu
  • Patent number: 5770222
    Abstract: Therapeutic drug delivery systems comprising gas-filled microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic drug delivery applications are also provided. Drug delivery systems comprising gas-filled liposomes having encapsulated therein a drug are preferred. Methods of and apparatus for preparing such liposomes and methods for employing such liposomes in drug delivery applications are also disclosed.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 23, 1998
    Assignee: ImaRx Pharmaceutical Corp.
    Inventors: Evan C. Unger, Thomas A. Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu
  • Patent number: 5769080
    Abstract: Contrast agents for ultrasonic imaging comprising gas filled liposomes prepared using vacuum drying gas instillation methods, and gas filled liposomes substantially devoid of liquid in the interior thereof, are described. Methods of and apparatus for preparing such liposomes and methods for employing such liposomes in ultrasonic imaging applications are also disclosed. Also described are diagnostic kits for ultrasonic imaging which include the subject contrast agents.
    Type: Grant
    Filed: February 22, 1994
    Date of Patent: June 23, 1998
    Assignee: DuPont Merck Pharmaceutical Company
    Inventors: Evan C. Unger, Guanli Wu