Patents by Inventor Gudrun Muth-Naumann

Gudrun Muth-Naumann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mutants of the factor VII-activating protease and detection methods using specific antibodies
    Patent number: 7863009
    Abstract: Mutants of the DNA sequence coding for the protease (FSAP) which activates blood clotting factor VII and single-chain plasminogen activators, the mutants comprising a G/C base exchange at nucleotide position 1177 and/or a G/A base exchange at nucleotide position 1601, are described. The corresponding protease has a Glu/Gln exchange at amino acid position 393 and/or a Gly/Glu exchange at amino acid position 534. Diagnostic methods which are used for detecting FSAP in body fluids or tissue cells and also for identifying patients with genetic heterozygous or homozygous FSAP expression are also described. In addition, antibodies against FSAP and its mutants are disclosed and diagnostic methods which can be used to detect antibodies against FSAP and its mutants are specified.
    Type: Grant
    Filed: September 16, 2008
    Date of Patent: January 4, 2011
    Assignee: CSL Behring GmbH
    Inventors: Juergen Roemisch, Hans-Arnold Stoehr, Annette Feussner, Wiegand Lang, Thomas Weimer, Margret Becker, Claudia Nerlich, Gudrun Muth-Naumann, Bernd Knoblauch
  • Inhibitory monoclonal antibody against blood clotting factor VII-activating protease
    Patent number: 7829095
    Abstract: A monoclonal antibody which inhibits the blood clotting factor VII-activating protease and its proenzyme and a blood clotting factor VII-activating protease, stabilized by the addition of said monoclonal antibody, and its proenzyme are described. A suitable monoclonal antibody is produced by hybridoma cell line DSM ACC 2533. The application of the inhibitory, monoclonal antibody in the stabilization of blood clotting preparations and in preparations for reducing the coagulability of the blood is disclosed.
    Type: Grant
    Filed: February 7, 2003
    Date of Patent: November 9, 2010
    Assignee: CSL Behring GmbH
    Inventors: Juergen Roemisch, Wiegand Lang, Annette Feussner, Gudrun Muth-Naumann, Hans-Arnold Stoehr, Christian Kannemaier, Klaus Preissner, Fumie Nakazawa
  • Marburg I mutant of factor VII activating protease (FSAP) as risk factor for arterial thrombosis and methods of detecting FSAP and FSAP mutations
    Patent number: 7803569
    Abstract: An arterial thrombosis risk factor comprising one or more of the identified mutants of coagulation factor VII activating protease (FSAP) is described. In addition, diagnostic determination methods for detecting these mutants which are identified as risk factors are described.
    Type: Grant
    Filed: December 5, 2006
    Date of Patent: September 28, 2010
    Assignee: CSL Behring GmbH
    Inventors: Stefan Kiechl, Johann Willeit, Christian Josef Wiedermann, Juergen Roemisch, Thomas Weimer, Annette Feussner, Hans-Arnold Stoehr, Volker Doersam, Wiegand Lang, Margret Becker, Claudia Nerlich, Gudrun Muth-Naumann, Bernd Knoblauch
  • Mutants of the factor VII-activating protease and detection methods using specific antibodies
    Publication number: 20090162871
    Abstract: Mutants of the DNA sequence coding for the protease (FSAP) which activates blood clotting factor VII and single-chain plasminogen activators, the mutants comprising a G/C base exchange at nucleotide position 1177 and/or a G/A base exchange at nucleotide position 1601, are described. The corresponding protease has a Glu/Gln exchange at amino acid position 393 and/or a Gly/Glu exchange at amino acid position 534. Diagnostic methods which are used for detecting FSAP in body fluids or tissue cells and also for identifying patients with genetic heterozygous or homozygous FSAP expression are also described. In addition, antibodies against FSAP and its mutants are disclosed and diagnostic methods which can be used to detect antibodies against FSAP and its mutants are specified.
    Type: Application
    Filed: September 16, 2008
    Publication date: June 25, 2009
    Inventors: Juergen Roemisch, Hans-Arnold Stoehr, Annette Feussner, Wiegand Lang, Thomas Weimer, Margret Becker, Claudia Nerlich, Gudrun Muth-Naumann, Bernd Knoblauch
  • Mutants of the factor VII-activating protease and detection methods using specific antibodies
    Patent number: 7442514
    Abstract: Mutants of the DNA sequence coding for the protease (FSAP) which activates blood clotting factor VII and single-chain plasminogen activators, the mutants comprising a G/C base exchange at nucleotide position 1177 and/or a G/A base exchange at nucleotide position 1601, are described. The corresponding protease has a Glu/Gln exchange at amino acid position 393 and/or a Gly/Glu exchange at amino acid position 534. Diagnostic methods which are used for detecting FSAP in body fluids or tissue cells and also for identifying patients with genetic heterozygous or homozygous FSAP expression are also described. In addition, antibodies against FSAP and its mutants are disclosed and diagnostic methods which can be used to detect antibodies against FSAP and its mutants are specified.
    Type: Grant
    Filed: September 1, 2004
    Date of Patent: October 28, 2008
    Assignee: CSL Behring GmbH
    Inventors: Juergen Roemisch, Hans-Arnold Stoehr, Annette Feussner, Wiegand Lang, Thomas Weimer, Margret Becker, Claudia Nerlich, Gudrun Muth-Naumann, Bernd Knoblauch
  • Marburg I mutant of factor VII activating protease (FSAP) as risk factor for arterial thrombosis and methods of detecting FSAP and FSAP mutations
    Publication number: 20070099229
    Abstract: A novel arterial thrombosis risk factor comprising one or more of the identified mutants of coagulation factor VII-activating protease (FSAP) is described. In addition, diagnostic determination methods for detecting these mutants which are identified as risk factors are described.
    Type: Application
    Filed: December 5, 2006
    Publication date: May 3, 2007
    Inventors: Stefan Kiechl, Johann Willeit, Christian Wiedermann, Juergen Roemisch, Thomas Weimer, Annette Feussner, Hans-Arnold Stoehr, Volker Doersam, Wiegand Lang, Margret Becker, Claudia Nerlich, Gudrun Muth-Naumann, Bernd Knoblauch
  • Marburg I mutant of factor VII activating protease (FSAP) as risk factor for arterial thrombosis
    Patent number: 7153679
    Abstract: A novel arterial thrombosis risk factor comprising one or more of the identified mutants of coagulation factor VII-activating protease (FSAP) is described. In addition, diagnostic determination methods for detecting these mutants which are identified as risk factors are described.
    Type: Grant
    Filed: March 19, 2003
    Date of Patent: December 26, 2006
    Assignee: Aventis Behring GmbH
    Inventors: Stefan Kiechl, Johann Willeit, Christian Josef Wiedermann, Juergen Roemisch, Thomas Weimer, Annette Feussner, Hans-Arnold Stoehr, Volker Doersam, Wiegand Lang, Margret Becker, Claudia Nerlich, Gudrun Muth-Naumann, Bernd Knoblauch
  • Mutants of the factor VII-activating protease and detection methods using specific antibodies
    Publication number: 20050032109
    Abstract: Mutants of the DNA sequence coding for the protease (FSAP) which activates blood clotting factor VII and single-chain plasminogen activators, the mutant comprising a G/C base exchange at nucleotide position 1177 and/or a G/A base exchange at nucleotide position 1601, is described. The corresponding protease has a Glu/Gln exchange at amino acid position 393 and/or a Gly/Glu exchange at amino acid position 534. Furthermore, diagnostic methods which are used for detecting FSAP in body fluids or tissue cells and also for identifying patients with genetic heterozygous or homozygous FSAP expression are described. In addition, antibodies against FSAP and its mutants are disclosed and diagnostic methods which can be used to detect antibodies against FSAP and its mutants are specified.
    Type: Application
    Filed: September 1, 2004
    Publication date: February 10, 2005
    Inventors: Juergen Roemisch, Hans-Arnold Stoehr, Annette Feussner, Wiegand Lang, Thomas Weimer, Margret Becker, Claudia Nerlich, Gudrun Muth-Naumann, Bernd Knoblauch
  • Mutants of the factor VII-activating protease and detection methods using specific antibodies
    Patent number: 6831167
    Abstract: Mutants of the DNA sequence coding for the protease (FSAP) which activates blood clotting factor VII and single-chain plasminogen activators, the mutants comprising a G/C base exchange at nucleotide position 1177 and/or a G/A base exchange at nucleotide position 1601, are described. The corresponding protease has a Glu/Gln exchange at amino acid position 393 and/or a Gly/Glu exchange at amino acid position 534. Diagnostic methods which are used for detecting FSAP in body fluids or tissue cells and also for identifying patients with genetic heterozygous or homozygous FSAP expression are also described. In addition, antibodies against FSAP and its mutants are disclosed and diagnostic methods which can be used to detect antibodies against FSAP and its mutants are specified.
    Type: Grant
    Filed: July 26, 2001
    Date of Patent: December 14, 2004
    Assignee: Aventis Behring GmbH
    Inventors: Juergen Roemisch, Hans-Arnold Stoehr, Annette Feussner, Wiegand Lang, Thomas Weimer, Margret Becker, Claudia Nerlich, Gudrun Muth-Naumann
  • Marburg I mutant of factor VII activating protease (FSAP) as risk factor for arterial thrombosis
    Publication number: 20040009543
    Abstract: A novel arterial thrombosis risk factor comprising one or more of the identified mutants of coagulation factor VII-activating protease (FSAP) is described. In addition, diagnostic determination methods for detecting these mutants which are identified as risk factors are described.
    Type: Application
    Filed: March 19, 2003
    Publication date: January 15, 2004
    Inventors: Stefan Kiechl, Johann Willeit, Christian Josef Wiedermann, Juergen Roemisch, Thomas Weimer, Annette Feussner, Hans-Arnold Stoehr, Volker Doersam, Wiegand Lang, Margret Becker, Claudia Nerlich, Gudrun Muth-Naumann, Bernd Knoblauch
  • Inhibitory monoclonal antibody against blood clotting factor VII-activating protease
    Publication number: 20030215447
    Abstract: A monoclonal antibody which inhibits the blood clotting factor VII-activating protease and its proenzyme and a blood clotting factor VII-activating protease, stabilized by the addition of said monoclonal antibody, and its proenzyme are described. A suitable monoclonal antibody is produced by hybridoma cell line DSM ACC 2533. The application of the inhibitory, monoclonal antibody in the stabilization of blood clotting preparations and in preparations for reducing the coagulability of the blood is disclosed.
    Type: Application
    Filed: February 7, 2003
    Publication date: November 20, 2003
    Inventors: Juergen Roemisch, Wiegand Lang, Annette Feussner, Gudrun Muth-Naumann, Hans-Arnold Stoehr, Christian Kannemaier, Klaus Preissner, Fumie Nakazawa
  • Mutants of the factor VII-activating protease and detection methods using specific antibodies
    Publication number: 20020142316
    Abstract: Mutants of the DNA sequence coding for the protease (FSAP) which activates blood clotting factor VII and single-chain plasminogen activators, the mutant comprising a G/C base exchange at nucleotide position 1177 and/or a G/A base exchange at nucleotide position 1601, is described. The corresponding protease has a Glu/Gin exchange at amino acid position 393 and/or a Gly/Glu exchange at amino acid position 534. Furthermore, diagnostic methods which are used for detecting FSAP in body fluids or tissue cells and also for identifying patients with genetic heterozygous or homozygous FSAP expression are described. In addition, antibodies against FSAP and its mutants are disclosed and diagnostic methods which can be used to detect antibodies against FSAP and its mutants are specified.
    Type: Application
    Filed: July 26, 2001
    Publication date: October 3, 2002
    Inventors: Juergen Roemisch, Hans-Arnold Stoehr, Annette Feussner, Wiegand Lang, Thomas Weimer, Margret Becker, Claudia Nerlich, Gudrun Muth-Naumann