Patents by Inventor Gudrun Stengel
Gudrun Stengel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11975328Abstract: The assembly includes a docking console and a manifold. The docking console includes a cartridge support surface having a first end and a second end. The manifold has one or more wells defined therein. The docking console further includes a manifold retention bracket to releasably hold the manifold against a fluid cartridge supported on the cartridge support surface at an interface position such that the one or more wells are in fluid communication with the fluid cartridge and a biased seal bar to press the fluid cartridge against the manifold held by the manifold retention bracket. A hydrophilic porous frit disposed within at least one of the wells and is to permit liquid to flow through the outlet aperture but prevent gas from passing through the outlet aperture.Type: GrantFiled: October 21, 2021Date of Patent: May 7, 2024Assignees: ILLUMINA, INC., ILLUMINA CAMBRIDGE LIMITEDInventors: Bradley Kent Drews, Gudrun Stengel, James Christopher Blake, Mohammed Kafeel Ahamed, Michael Steven Becker, Michael Dangelo, Mark J. Nibbe, Daniel L. Fuller, Oliver Jon Miller
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Publication number: 20240110222Abstract: Provided herein are compositions and methods for the multiplexed profiling of RNA and DNA modifications across transcriptomes and genomes, respectively. The methods combine molecular recognition of non-canonical features (e.g., base modifications, backbone modifications, lesions, and/or structural elements) of a target nucleic acid with a step of writing the information from this recognition event into the neighboring genetic sequence of the target nucleic acid using a barcode. The resultant barcoded nucleic acids are then converted into sequencing libraries and read by DNA/RNA sequencing methods. This step reveals the sequence of the barcode, which is correlated with the non-canonical feature in the target nucleic acid(s). The high throughput profiling methods described herein allow for localization of one or more modifications in a target nucleic acid. The methods also allow for identification of the nature and location of several or all DNA/RNA modifications in parallel.Type: ApplicationFiled: October 2, 2023Publication date: April 4, 2024Applicant: Alida Biosciences Inc.Inventors: Gudrun Stengel, Byron Purse, Yu-Hsien Hwang-Fu, Jerome Santos
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Publication number: 20240002921Abstract: Provided herein are compositions and methods for the multiplexed profiling of RNA and DNA modifications across transcriptomes and genomes, respectively. The methods combine molecular recognition of non-canonical features (e.g., base modifications, backbone modifications, lesions, and/or structural elements) of a target nucleic acid with a step of writing the information from this recognition event into the neighboring genetic sequence of the target nucleic acid using a barcode. The resultant barcoded nucleic acids are then converted into sequencing libraries and read by DNA/RNA sequencing methods. This step reveals the sequence of the barcode, which is correlated with the non-canonical feature in the target nucleic acid(s). The high throughput profiling methods described herein allow for identification and/or localization of one or more modifications in a target nucleic acid. The methods also allow for identification of the nature and location of several or all DNA/RNA modifications in parallel.Type: ApplicationFiled: June 28, 2023Publication date: January 4, 2024Applicant: ALIDA BIOSCIENCES, INC.Inventors: Gudrun STENGEL, Hua YU, Andrew PRICE, Jerome SANTOS, Yu-Hsien HWANG-FU, Byron PURSE
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Publication number: 20230416828Abstract: Provided herein are compositions and methods for the multiplexed profiling of RNA and DNA modifications across transcriptomes and genomes, respectively. The methods combine molecular recognition of non-canonical features (e.g., base modifications, backbone modifications, lesions, and/or structural elements) of a target nucleic acid with a step of writing the information from this recognition event into the neighboring genetic sequence of the target nucleic acid using a barcode. The resultant barcoded nucleic acids are then converted into sequencing libraries and read by DNA/RNA sequencing methods. This step reveals the sequence of the barcode, which is correlated with the non-canonical feature in the target nucleic acid(s). The high throughput profiling methods described herein allow for identification and/or localization of one or more modifications in a target nucleic acid. The methods also allow for identification of the nature and location of several or all DNA/RNA modifications in parallel.Type: ApplicationFiled: June 28, 2023Publication date: December 28, 2023Applicant: ALIDA BIOSCIENCES, INC.Inventors: Gudrun STENGEL, Hua YU, Andrew PRICE, Jerome SANTOS, Yu-Hsien HWANG-FU, Byron PURSE
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Patent number: 11773425Abstract: Provided herein are compositions and methods for the multiplexed profiling of RNA and DNA modifications across transcriptomes and genomes, respectively. The methods combine molecular recognition of non-canonical features (e.g., base modifications, backbone modifications, lesions, and/or structural elements) of a target nucleic acid with a step of writing the information from this recognition event into the neighboring genetic sequence of the target nucleic acid using a barcode. The resultant barcoded nucleic acids are then converted into sequencing libraries and read by DNA/RNA sequencing methods. This step reveals the sequence of the barcode, which is correlated with the non-canonical feature in the target nucleic acid(s). The high throughput profiling methods described herein allow for localization of one or more modifications in a target nucleic acid. The methods also allow for identification of the nature and location of several or all DNA/RNA modifications in parallel.Type: GrantFiled: March 28, 2022Date of Patent: October 3, 2023Assignee: Alida Biosciences Inc.Inventors: Gudrun Stengel, Byron Purse, Yu-Hsien Hwang-Fu, Jerome Santos
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Publication number: 20220298543Abstract: Provided herein are compositions and methods for the multiplexed profiling of RNA and DNA modifications across transcriptomes and genomes, respectively. The methods combine molecular recognition of non-canonical features (e.g., base modifications, backbone modifications, lesions, and/or structural elements) of a target nucleic acid with a step of writing the information from this recognition event into the neighboring genetic sequence of the target nucleic acid using a barcode. The resultant barcoded nucleic acids are then converted into sequencing libraries and read by DNA/RNA sequencing methods. This step reveals the sequence of the barcode, which is correlated with the non-canonical feature in the target nucleic acid(s). The high throughput profiling methods described herein allow for localization of one or more modifications in a target nucleic acid. The methods also allow for identification of the nature and location of several or all DNA/RNA modifications in parallel.Type: ApplicationFiled: March 28, 2022Publication date: September 22, 2022Applicant: Alida Biosciences Inc.Inventors: Gudrun Stengel, Byron Purse, Yu-Hsien Hwang-Fu, Jerome Santos
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Publication number: 20220298542Abstract: Provided herein are compositions and methods for the multiplexed profiling of RNA and DNA modifications across transcriptomes and genomes, respectively. The methods combine molecular recognition of non-canonical features (e.g., base modifications, backbone modifications, lesions, and/or structural elements) of a target nucleic acid with a step of writing the information from this recognition event into the neighboring genetic sequence of the target nucleic acid using a barcode. The resultant barcoded nucleic acids are then converted into sequencing libraries and read by DNA/RNA sequencing methods. This step reveals the sequence of the barcode, which is correlated with the non-canonical feature in the target nucleic acid(s). The high throughput profiling methods described herein allow for localization of one or more modifications in a target nucleic acid. The methods also allow for identification of the nature and location of several or all DNA/RNA modifications in parallel.Type: ApplicationFiled: March 28, 2022Publication date: September 22, 2022Applicant: Alida Biosciences Inc.Inventors: Gudrun Stengel, Byron Purse, Yu-Hsien Hwang-Fu, Jerome Santos
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Publication number: 20220106636Abstract: Provided herein are methods of making, amplifying, and sequencing tagged nucleic acid complements, compositions including interposing oligonucleotide barcodes, and kits useful in obtaining long-range sequence data.Type: ApplicationFiled: September 27, 2021Publication date: April 7, 2022Inventors: Eli N. GLEZER, Martin Maria FABANI, Ryan SHULTZABERGER, Bharat SRIDHAR, Gudrun STENGEL, Christopher Jen-Yue WEI
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Publication number: 20220042087Abstract: Provided herein are methods of making, amplifying, and sequencing tagged nucleic acid complements, compositions including interposing oligonucleotide barcodes, and kits useful in obtaining long-range sequence data.Type: ApplicationFiled: October 8, 2021Publication date: February 10, 2022Inventors: Eli N. GLEZER, Martin Maria FABANI, Ryan SHULTZABERGER, Bharat SRIDHAR, Gudrun STENGEL, Christopher Jen-Yue WEI
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Publication number: 20220040690Abstract: The assembly includes a docking console and a manifold. The docking console includes a cartridge support surface having a first end and a second end. The manifold has one or more wells defined therein. The docking console further includes a manifold retention bracket to releasably hold the manifold against a fluid cartridge supported on the cartridge support surface at an interface position such that the one or more wells are in fluid communication with the fluid cartridge and a biased seal bar to press the fluid cartridge against the manifold held by the manifold retention bracket. A hydrophilic porous frit disposed within at least one of the wells and is to permit liquid to flow through the outlet aperture but prevent gas from passing through the outlet aperture.Type: ApplicationFiled: October 21, 2021Publication date: February 10, 2022Applicants: Illumina, Inc., Illumina Cambridge LimitedInventors: Bradley Kent DREWS, Gudrun STENGEL, James Christopher BLAKE, Mohammed Kafeel AHAMED, Michael Steven BECKER, Michael Dangelo, Mark J. NIBBE, Daniel L. FULLER, Oliver Jon MILLER
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Patent number: 11179724Abstract: The assembly includes a docking console and a manifold. The docking console includes a cartridge support surface having a first end and a second end. The manifold has one or more wells defined therein. The docking console further includes a manifold retention bracket to releasably hold the manifold against a fluid cartridge supported on the cartridge support surface at an interface position such that the one or more wells are in fluid communication with the fluid cartridge and a biased seal bar to press the fluid cartridge against the manifold held by the manifold retention bracket. A hydrophilic porous frit disposed within at least one of the wells and is to permit liquid to flow through the outlet aperture but prevent gas from passing through the outlet aperture.Type: GrantFiled: September 11, 2018Date of Patent: November 23, 2021Assignees: Illumina, Inc., Illumina Cambridge LimitedInventors: Bradley Kent Drews, Gudrun Stengel, James Christopher Blake, Mohammed Kafeel Ahamed, Michael Steven Becker, Michael Dangelo, Mark J. Nibbe, Daniel L. Fuller, Oliver Jon Miller
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Patent number: 11155858Abstract: Provided herein are methods of making, amplifying, and sequencing tagged nucleic acid complements, compositions including interposing oligonucleotide barcodes, and kits useful in obtaining long-range sequence data.Type: GrantFiled: December 18, 2020Date of Patent: October 26, 2021Assignee: SINGULAR GENOMICS SYSTEMS, INC.Inventors: Eli N. Glezer, Martin Maria Fabani, Ryan Shultzaberger, Bharat Sridhar, Gudrun Stengel, Christopher Jen-Yue Wei
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Publication number: 20210198730Abstract: Provided herein are methods of making, amplifying, and sequencing tagged nucleic acid complements, compositions including interposing oligonucleotide barcodes, and kits useful in obtaining long-range sequence data.Type: ApplicationFiled: December 18, 2020Publication date: July 1, 2021Inventors: Eli N. GLEZER, Martin Maria FABANI, Ryan SHULTZABERGER, Bharat SRIDHAR, Gudrun STENGEL, Christopher Jen-Yue WEI
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Publication number: 20190091682Abstract: The assembly includes a docking console and a manifold. The docking console includes a cartridge support surface having a first end and a second end. The manifold has one or more wells defined therein. The docking console further includes a manifold retention bracket to releasably hold the manifold against a fluid cartridge supported on the cartridge support surface at an interface position such that the one or more wells are in fluid communication with the fluid cartridge and a biased seal bar to press the fluid cartridge against the manifold held by the manifold retention bracket. A hydrophilic porous frit disposed within at least one of the wells and is to permit liquid to flow through the outlet aperture but prevent gas from passing through the outlet aperture.Type: ApplicationFiled: September 11, 2018Publication date: March 28, 2019Applicants: lllumina, Inc., lllumina Cambridge LimitedInventors: Bradley Kent Drews, Gudrun Stengel, James Christopher Blake, Mohammed Kafeel Ahamed, Michael Steven Becker, Michael Dangelo, Mark J. Nibbe, Daniel L. Fuller, Oliver Jon Miller