Patents by Inventor Gueijun Ji

Gueijun Ji has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process improvements in steroid chemistry
    Patent number: 6982329
    Abstract: Steroids containing a cyclohexene moiety are efficiently oxidized to the corresponding ?,?-unsaturated ketone using copper iodide and t-butyl hydroperoxide. A steroid compound containing the ?,?-unsaturated ketone structure is efficiently converted to the corresponding vicinal diol using a hydroborating reagent followed by oxidative workup, e.g., borane followed by sodium perborate. Benzoyl and substituted benzoyls are superior protecting groups for hydroxyl groups present in the compounds.
    Type: Grant
    Filed: December 22, 2003
    Date of Patent: January 3, 2006
    Assignee: Inflazyme Pharmaceuticals Ltd.
    Inventors: David L. Burgoyne, Gueijun Ji, Eugene W. Kelleher, Nicholas D. Paschalides, Kishore Ramachandran, Yaping Shen, Yuanlin Zhou
  • Process for the production of 6, 7- dihydroxy steroid compounds by allylic oxidation of steroid - 5 - ene compounds to steroid - 5 - ene - 7 - one compounds followed by hydroboration and oxidation and intermediates of this process
    Publication number: 20040266744
    Abstract: Steroids containing a cyclohexene moiety are efficiently oxidized to the corresponding &agr;, &bgr;-unsaturated ketone using copper iodide and t-butyl hydroperoxide. A steroid compound containing the &agr;, &bgr;-unsaturated ketone structure is efficiently converted to the corresponding vicinal diol using a hydroborating reagent followed by oxidative workup, e.g., borane followed by sodium perborate. Benzoyl and substituted benzoyls are superior protecting groups for hydroxyl groups present in the compounds.
    Type: Application
    Filed: July 15, 2004
    Publication date: December 30, 2004
    Inventors: David L Burgoyne, Yaping Shen, Gueijun Ji, Yuanlin Zhou, Kishore D. Ramachandran, Nicholas D. Paschalides, Eugene W. Kelleher
  • Process improvements in steroid chemistry
    Publication number: 20040138486
    Abstract: Steroids containing a cyclohexene moiety are efficiently oxidized to the corresponding &agr;,&bgr;-unsaturated ketone using copper iodide and t-butyl hydroperoxide. A steroid compound containing the &agr;,&bgr;-unsaturated ketone structure is efficiently converted to the corresponding vicinal diol using a hydroborating reagent followed by oxidative workup, e.g., borane followed by sodium perborate. Benzoyl and substituted benzoyls are superior protecting groups for hydroxyl groups present in the compounds.
    Type: Application
    Filed: December 22, 2003
    Publication date: July 15, 2004
    Applicant: Inflazyme Pharmaceuticals Ltd.
    Inventors: David L. Burgoyne, Gueijun Ji, Eugene W. Kelleher, Nicholas D. Paschalides, Kishore Ramachandran, Yaping Shen, Yuanlin Zhou
  • Process for the production of 6,7-diols of steroidal compounds
    Patent number: 6696580
    Abstract: Steroids containing a cyclohexene moiety are efficiently oxidized to the corresponding &agr;,&bgr;-unsaturated ketone using copper iodide and t-butyl hydroperoxide. A steroid compound containing the &agr;,&bgr;-unsaturated ketone structure is efficiently converted to the corresponding vicinal diol using a hydroborating reagent followed by oxidative workup, e.g., borane followed by sodium perborate. Benzoyl and substituted benzoyls are superior protecting groups for hydroxyl groups present in the compounds.
    Type: Grant
    Filed: May 22, 2002
    Date of Patent: February 24, 2004
    Assignee: Inflazyme Pharmaceuticals Ltd.
    Inventors: David L. Burgoyne, Gueijun Ji, Eugene W. Kelleher, Nicholas D. Paschalides, Kishore Ramachandran, Yaping Shen, Yuanlin Zhou
  • Process improvements in steroid chemistry
    Publication number: 20030050286
    Abstract: Steroids containing a cyclohexene moiety are efficiently oxidized to the corresponding &agr;,&bgr;-unsaturated ketone using copper iodide and t-butyl hydroperoxide. A steroid compound containing the &agr;,&bgr;-unsaturated ketone structure is efficiently converted to the corresponding vicinal diol using a hydroborating reagent followed by oxidative workup, e.g., borane followed by sodium perborate. Benzoyl and substituted benzoyls are superior protecting groups for hydroxyl groups present in the compounds.
    Type: Application
    Filed: May 22, 2002
    Publication date: March 13, 2003
    Inventors: David L. Burgoyne, Gueijun Ji, Eugene W. Kelleher, Nicholas D. Paschalides, Kishore Ramachandran, Yaping Shen, Yuanlin Zhou