Abstract: Disclosed herein are methods of determining polydispersity (PDI) and molecular mass distribution (MMD) of reactive PEG samples using mass spectrometry. More specifically, a mass spectrometry method called GEMMA is used to determine PDI and MMD of PEG samples which provides more accurate measurements for high molecular weight PEG samples than prior known MALDI-TOF analysis.

Abstract: Methods for determining molecular mass of at least 150 kDa of an analyte of interest using MALDI mass spectrometry in combination with a recombinant von Willebrand factor (rVWF) molecular weight marker are disclosed. More specifically, monomeric and multimeric rVWF are used for external and internal calibration of mass spectra applied for analytes having high molecular weights above 150 kDa.

Abstract: Disclosed herein are methods of determining polydispersity (PDI) and molecular mass distribution (MMD) of reactive PEG samples using mass spectrometry. More specifically, a mass spectrometry method called GEMMA is used to determine PDI and MMD of PEG samples which provides more accurate measurements for high molecular weight PEG samples than prior known MALDI-TOF analysis.

Abstract: In a method for classifying and separating particles in a fluid stream in which the particles are sprayed and electrically charged and deflected in an electrical field one portion of the stream of the charged or ionized particles respectively is introduced into a first separation device operated as an analyzer (4) and is deflected under variation of the applied high voltage or the electric field respectively, whereby particles reach a detector chamber (10) according to separation criteria like, for example charge or particle size. This high voltage and/or field strength corresponding to a species collected in the detector chamber (10) is read and/or stored as a reference value. The particle stream is fed into a separator (5), in which the previously acquired high voltage and/or field strength is applied and particles of the species deflected in the analyzer (4) into the detector chamber (10) are enriched and discharged correspondingly.