Patents by Inventor Guenter Grethe

Guenter Grethe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of methyl 3,4-anhydro-2,6-dideoxy-L-ribohexopyranoside
    Patent number: 4310462
    Abstract: A process to produce methyl 3,4-anhydro-2,6-dideoxy-L-ribohexopyranoside, its enantiomer and racemate thereof.The compound is useful as an intermediate in the production of daunosamine which in turn is a prime constituent in the anti-cancer agents Daunomycin and Adriamycin. Also disclosed are novel intermediates in the process.
    Type: Grant
    Filed: October 17, 1980
    Date of Patent: January 12, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Guenter Grethe, Milan R. Uskokovic, John Sereno
  • 3,4-Anhydro-2,6-dideoxy-L-ribohexose
    Patent number: 4238399
    Abstract: A process to produce methyl 3,4-anhydro-2,6-dideoxy-L-ribohexopyranoside, its enantiomer and racemate thereof.The compound is useful as an intermediate in the production of daunosamine which in turn is a prime constituent in the anti-cancer agents Daunomycin and Adriamycin. Also disclosed are novel intermediates in the process.
    Type: Grant
    Filed: June 13, 1979
    Date of Patent: December 9, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Guenter Grethe, Milan R. Uskokovic, John Sereno
  • Process for the preparation of methyl 3,4-anhydro-2,6-dideoxy-L-ribo-hexopyranoside
    Patent number: 4228080
    Abstract: A process to produce methyl 3,4-anhydro-2,6-dideoxy-L-ribohexopyranoside, its enantiomer and racemate thereof.The compound is useful as an intermediate in the production of daunosamine which in turn is a prime constituent in the anti-cancer agents Daunomycin and Adriamycin. Also disclosed are novel intermediates in the process.
    Type: Grant
    Filed: June 13, 1979
    Date of Patent: October 14, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Guenter Grethe, Milan R. Uskokovic, John Sereno
  • Process for the preparation of methyl 3,4-anhydro-2,6-dideoxy-L-ribo-hexopyranoside
    Patent number: 4174344
    Abstract: A process to produce methyl 3,4-anhydro-2,6-dideoxy-L-ribohexopyranoside, its enantiomer and racemate thereof.The compound is useful as an intermediate in the production of daunosamine which in turn is a prime constituent in the anti-cancer agents Daunomycin and Adriamycin. Also disclosed are novel intermediates in the process.
    Type: Grant
    Filed: November 14, 1977
    Date of Patent: November 13, 1979
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Guenter Grethe, Milan R. Uskokovic, John Sereno
  • Processes and intermediates for cis or trans 2-or 3-(1-acyl-3-vinyl-4-piperidine)acetic or propionic acid esters
    Patent number: 4012396
    Abstract: Cis or trans 2-(1-acyl-3-vinyl-4-piperidine)acetic acid esters and cis or trans 3-(1-acyl-3-vinyl-4-piperidine)propionic acid esters, antipodes and racemates thereof, are prepared, inter alia, from the corresponding cis or trans 2- or 3-[1-acyl-3-(2-chloroethyl)-4-piperidine]acetic or propionic acid esters, respectively. The cis or trans 2- or 3-(1-acyl-3-vinyl-4-piperidine)acetic or propionic acid esters are useful as intermediates for the synthesis of quinine and quinidine and analogs and stereoisomers thereof.
    Type: Grant
    Filed: May 23, 1975
    Date of Patent: March 15, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Guenter Grethe, Milan Radoje Uskokovic
  • Processes and intermediates for cis or trans 2- or 3-(1-acyl-3-vinyl-4-piperidine)acetic or propionic acid esters
    Patent number: 3959294
    Abstract: Cis or trans 2-(1-acyl-3-vinyl-4-piperidine)acetic acid esters and cis or trans 3-(1-acyl-3-vinyl-4-piperidine)propionic acid esters, antipodes and racemates thereof, are prepared, inter alia, from the corresponding cis or trans 2- or 3-[1-acyl-3-(2-chloroethyl)-4-piperidine]acetic or propionic acid esters, respectively. The cis or trans 2- or 3-(1-acyl-3-vinyl-4-piperidine)acetic or propionic acid esters are useful as intermediates for the synthesis of quinine and quinidine and analogs and stereoisomers thereof.
    Type: Grant
    Filed: May 23, 1975
    Date of Patent: May 25, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Guenter Grethe, Milan Radoje Uskokovic
  • Processes and intermediates for cis or trans 2- or 3-(1-acyl-3-vinyl-4-piperidine)acetic or propionic acid esters
    Patent number: 3957800
    Abstract: Cis or trans 2-(1-acyl-3-vinyl-4-piperidine)acetic acid esters and cis or trans 3-(1-acyl-3-vinyl-4-piperidine)propionic acid esters, antipodes and racemates thereof, are prepared, inter alia, from the corresponding cis or trans 2- or 3[1-acyl-3-(2-chloroethyl)-4-piperidine]acetic or propionic acid esters, respectively. The cis or trans 2- or 3-(1-acyl-3-vinyl-4-piperidine)acetic or propionic acid esters are useful as intermediates for the synthesis of quinine and quinidine and analogs and stereoisomers thereof.
    Type: Grant
    Filed: May 23, 1975
    Date of Patent: May 18, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Guenter Grethe, Milan Radoje Uskokovic
  • Trifluoromethyl substituted analogs of quinine and quinidine
    Patent number: 3953453
    Abstract: Trifluoromethyl substituted analogs of quinine and quinidine are prepared by reacting a 4-quinolyllithium compound with a 4,5-erythro-5-ethyl-(or vinyl)-quinuclidine-2 .xi.-carboxaldehyde or the corresponding quinuclidine-2 .xi.-carboxylic acid alkyl ester. The end products are useful as antimalarial agents.
    Type: Grant
    Filed: November 11, 1974
    Date of Patent: April 27, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Guenter Grethe, Milan Radoje Uskokovic
  • Process for piperidine intermediates for quinine, quinidine and analogs thereof
    Patent number: 3931192
    Abstract: Quinine, quinidine and analogs thereof, are prepared by reacting a 4-quinolyllithium compound with a 4,5-erythro-5-ethyl(or vinyl)-quinuclidine-2.epsilon. -carboxaldehyde or the corresponding quinuclidine-2-carboxylic acid alkyl ester. Also described, inter alia, is the preparation of a 4,5-erythro-5-ethyl(or vinyl)-quinuclidine-2.epsilon.-carboxaldehyde, and a 4,5-crythro-5-ethyl(or vinyl)-quinuclidine-2.epsilon. -carboxylic acid and esters thereof. The end products are useful as antimalarial and antiarrhythmic agents.
    Type: Grant
    Filed: May 2, 1974
    Date of Patent: January 6, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Guenter Grethe, Milan Radoje Uskokovic
  • Quinuclidine derivatives
    Patent number: 3931193
    Abstract: Quinine, quinidine and analogs thereof, are prepared by reacting a 4-quinolyllithium compound with a 4,5-erythro-5-ethyl(or vinyl)-quinuclidine-2 .xi.-carboxaldehyde or the corresponding quinuclidine-2-carboxylic acid alkyl ester. Also described, inter alia, is the preparation of a 4,5-erythro-5-ethyl(or vinyl)-quinuclidine-2 .xi.-carboxaldehyde, and a 4,5-erythro-5-ethyl(or vinyl)-quinuclidine-2 .xi.-carboxylic acid and esters thereof. The end products are useful as anti-malarial and antiarrhythmic agents.
    Type: Grant
    Filed: May 2, 1974
    Date of Patent: January 6, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Guenter Grethe, Milan Radoje Uskokovic