Patents by Inventor Guenter Knaup
Guenter Knaup has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240409886Abstract: The present invention relates to a culture medium, preferably a cell culture medium, comprising at least one dipeptide, the dipeptide comprising asparagine (Asn) and glutamine (Gln). The invention further relates to the use of a culture medium of the invention for culturing cells, preferably plant cells, animal cells or mammalian cells. Another aspect of the invention relates to a method of manufacturing a cell culture product comprising the steps of (i) providing a cell capable of producing said cell culture product; (ii) contacting said cell with a culture medium according to the invention; and (iii) obtaining said cell culture product from said culture medium or from said cell.Type: ApplicationFiled: August 22, 2024Publication date: December 12, 2024Applicant: Evonik Operations GmbHInventors: Friedhelm MERZ, Andreas KARAU, Thomas HERMANN, Guenter KNAUP
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Patent number: 12115260Abstract: The present invention relates to a tablet comprising one or more omega-3 fatty acid amino acid salt(s), a method for preparing a tablet according to the invention and the use of a tablet according to the invention as a food supplement or as a pharmaceutical product.Type: GrantFiled: May 24, 2017Date of Patent: October 15, 2024Assignee: Evonik Operations GmbHInventors: Thomas Gottstein, Guenter Knaup, Michael Schwarm
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Patent number: 11622952Abstract: The present invention relates to a tablet comprising one or more omega-3 fatty acid amino acid salts, a method for preparing a tablet according to the invention and the use of a tablet according to the invention as a food supplement or as a pharmaceutical product.Type: GrantFiled: August 15, 2018Date of Patent: April 11, 2023Assignee: Evonik Operations GmbHInventors: Thomas Gottstein, Michael Schwarm, Guenter Knaup
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Patent number: 11441119Abstract: Disclosed herein is a cell culture media containing L-glutamine from a set of N-acylated dipeptides Acyl-X-Q, and L-glutamine from a set of other glutamine-sources Qsource in a defined molar ratio R=n(Acyl-X-Q)/n(Qsource), wherein the variables X, Q, Acyl, R, n(Acyl-X-Q) and n(Qsource) are defined in the general disclosure. Processes of using the cell culture media are also described herein.Type: GrantFiled: March 2, 2018Date of Patent: September 13, 2022Assignee: Evonik Operations GmbHInventors: Guenter Knaup, Friedhelm Merz
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Patent number: 11219235Abstract: The present invention relates to a method for preparing a composition comprising one or more omega-3 fatty acid salt(s), the composition obtainable or obtained by this method, and also the use of this composition for the preparation of foodstuffs, food supplements or pharmaceutical products.Type: GrantFiled: May 24, 2017Date of Patent: January 11, 2022Assignee: Evonik Operations GmbHInventors: Guenter Knaup, Milan Latinovic, Joerg Lotz, Michael Schwarm
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Publication number: 20210121429Abstract: The present invention relates to a tablet comprising one or more omega-3 fatty acid amino acid salts, a method for preparing a tablet according to the invention and the use of a tablet according to the invention as a food supplement or as a pharmaceutical product.Type: ApplicationFiled: August 15, 2018Publication date: April 29, 2021Applicant: Evonik Operations GmbHInventors: Thomas GOTTSTEIN, Michael SCHWARM, Guenter KNAUP
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Publication number: 20200315230Abstract: The present invention relates to a method for preparing a composition comprising one or more omega-3 fatty acid salt(s), the composition obtainable or obtained by this method, and also the use of this composition for the preparation of foodstuffs, food supplements or pharmaceutical products.Type: ApplicationFiled: May 24, 2017Publication date: October 8, 2020Applicant: EVONIK TECHNOCHEMIE GMBHInventors: Guenter KNAUP, Milan LATINOVIC, Jörg LOTZ, Michael SCHWARM
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Publication number: 20200315970Abstract: The present invention relates to a tablet comprising one or more omega-3 fatty acid amino acid salt(s), a method for preparing a tablet according to the invention and the use of a tablet according to the invention as a food supplement or as a pharmaceutical product.Type: ApplicationFiled: May 24, 2017Publication date: October 8, 2020Applicant: Evonik Technochemie GmbHInventors: Thomas GOTTSTEIN, Guenter KNAUP, Michael SCHWARM
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Publication number: 20200024571Abstract: Disclosed herein is a cell culture media containing L-glutamine from a set of N-acylated dipeptides Acyl-X-Q, and L-glutamine from a set of other glutamine-sources Qsource in a defined molar ratio R=n(Acyl-X-Q)/n(Qsource), wherein the variables X, Q, Acyl, R, n(Acyl-X-Q) and n(Qsource) are defined in the general disclosure. Processes of using the cell culture media are also described herein.Type: ApplicationFiled: March 2, 2018Publication date: January 23, 2020Applicant: Evonik Degussa GmbHInventors: Guenter KNAUP, Friedhelm MERZ
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Publication number: 20200010796Abstract: The present invention relates to a culture medium, preferably a cell culture medium, comprising at least one dipeptide, the dipeptide comprising asparagine (Asn) and glutamine (Gln). The invention further relates to the use of a culture medium of the invention for culturing cells, preferably plant cells, animal cells or mammalian cells. Another aspect of the invention relates to a method of manufacturing a cell culture product comprising the steps of (i) providing a cell capable of producing said cell culture product; (ii) contacting said cell with a culture medium according to the invention; and (iii) obtaining said cell culture product from said culture medium or from said cell.Type: ApplicationFiled: March 2, 2018Publication date: January 9, 2020Applicant: Evonik Degussa GmbHInventors: Friedhelm MERZ, Andreas KARAU, Thomas HERMANN, Guenter KNAUP
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Publication number: 20190390161Abstract: The invention relates to a culture medium containing at least one oligopeptide of 2-10 amino acids in length. The amino acids are natural amino acids. At least one of the amino acids is lysine; and one further is cysteine, cystine, leucine, tyrosine, valine, or Isoleucine. The oligopeptide is present in an amount of at least 0.1 mM. The invention also relates to the use of the culture medium for culturing cells, preferably plant cells, animal cells or mammalian cells. The invention further relates to a method of manufacturing a cell culture product including the steps of (i) providing a cell capable of producing the cell culture product; (ii) contacting the cell with the culture medium, and (iii) obtaining the cell culture product from the culture medium or from the cell.Type: ApplicationFiled: March 2, 2018Publication date: December 26, 2019Applicant: Evonik Degussa GmbHInventors: Guenter KNAUP, Friedhelm MERZ, Christian KESSLER
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PROCESS FOR INCREASING THE STABILITY OF A COMPOSITION COMPRISING POLYUNSATURATED OMEGA-6 FATTY ACIDS
Publication number: 20170367394Abstract: A processes for increasing the stability of a composition containing polyunsaturated an omega-6 fatty acid against oxidation proceeds by (i) providing a starting composition containing at least one polyunsaturated omega-6 fatty acid component; (ii) providing a lysine composition; (iii) admixing an aqueous, an aqueous-alcoholic or an alcoholic solution of starting composition and lysine composition, and subjecting a resulting admixture to spray drying conditions subsequently, thus forming a solid product composition containing at least one salt of a cation derived from lysine with an anion derived from the polyunsaturated omega-6 fatty acid; the product composition exhibiting a solvent content SC selected from the following; SC<5 wt %, SC<3 wt %, SC<1 wt %, or <0.5 wt %.Type: ApplicationFiled: December 17, 2015Publication date: December 28, 2017Applicant: Evonik Degussa GmbHInventors: Guenter KNAUP, Milan LATINOVIC, Michael SCHWARM -
PROCESS FOR INCREASING THE STABILITY OF A COMPOSITION COMPRISING POLYUNSATURATED OMEGA-3 FATTY ACIDS
Publication number: 20170360072Abstract: A process for increasing the stability of a composition containing a polyunsaturated omega-3 fatty acid against oxidation proceeds by (i) providing a starting composition containing at least one polyunsaturated omega-3 fatty acid component; (ii) providing a lysine composition; (iii) admixing an aqueous, an aqueous-alcoholic or an alcoholic solution of starting composition and lysine composition, and subjecting resulting admixture to spray drying conditions subsequently, thus forming a solid product composition containing at least one salt of a cation derived from lysine with an anion derived from a polyunsaturated omega-3 fatty acid; the product composition exhibiting a solvent content SC selected from the following: SC<5 wt %, SC<3 wt %, SC<1 wt %, or SC<0.5 wt %.Type: ApplicationFiled: December 17, 2015Publication date: December 21, 2017Applicant: Evonik Degussa GmbHInventors: Guenter KNAUP, Milan LATINOVIC, Michael SCHWARM -
Patent number: 6830692Abstract: The invention relates to a special amino acid mixture for hemodialysis as well as to the dialysis solution that can be prepared from the amino acid mixture. When the amino acid mixtures according to the invention are used for such purposes, the “shrinking men” phenomenon cam be prevented. The present invention also relates to a hemodialysis process and apparatus. This aspect of the invention provides a closed dialysis system with a dialyzer solution containing the amino acid mixtures according to the invention.Type: GrantFiled: September 20, 1999Date of Patent: December 14, 2004Assignee: Degussa AGInventors: Karlheinz Drauz, Guenter Knaup, Gerard Richet, Werner Kleophas, Adolf Gruenert
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Patent number: 6787039Abstract: The invention relates to a special amino acid mixture for hemodialysis as well as to the dialysis solution that can be prepared from the amino acid mixture. When the amino acid mixtures according to the invention are used for such purposes, the “shrinking men” phenomenon can be prevented. The present invention also relates to a hemodialysis process and apparatus. This aspect of the invention provides a closed dialysis system with a dialyzer solution containing the amino acid mixtures according to the invention.Type: GrantFiled: January 26, 2001Date of Patent: September 7, 2004Assignee: Degussa AGInventors: Karlheinz Drauz, Guenter Knaup, Gerard Richet, Werner Kleophas, Adolf Gruenert
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Patent number: 6673942Abstract: The present invention relates to a process for the resolution of DL-racemic mixtures of compounds which crystalize in the form of a conglumerate. Both, the D and L-enantiomers are obtained according to the invention in a industrially feasable process by adding chiral enantioselective polymers to the supersaturated solution of the racemat to inhibit crystalization of one enantiomer. Next a DL-racemic mixture of said compound is suspended in about twice the amount of the crystallized enantiomer. Consequently, the opposite enantiomer could be recovered by said suspension by physical separation.Type: GrantFiled: July 23, 2002Date of Patent: January 6, 2004Assignees: Degussa AG, Yeda Research and Development Co., Ltd.Inventors: Matthias Kottenhahn, Guenter Knaup, Karlheinz Drauz, Meir Lahav, David Zbaida
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Publication number: 20020144946Abstract: An amino acid composition suitable for hemodialysis and a dialysis solution that can be prepared from the amino acid mixture. When the inventive amino acid composition is used for this purpose, the “shrinking men” phenomenon can be prevented. Also provides are a hemodialysis process and apparatus.Type: ApplicationFiled: January 26, 2001Publication date: October 10, 2002Inventors: Karlheinz Drauz, Guenter Knaup, Gerard Richet, Werner Kleophas, Adolf Gruenert
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Patent number: 5304470Abstract: Protected and unprotected di- or oligopeptides are synthesized by reacting an N-terminally protected .alpha.-amino acid alkyl ester or peptide alkyl ester of the formula X--E--R.sup.1 with an amino acid or a di- or oligopeptide or a derivative thereof of the formula H.sub.2 N--Q--R.sup.2 in aqueous solution in the presence of a hydrolase, and, removing protective groups from the reaction product separated from the reaction mixture, where E is the residue of an .alpha.-amino acid or of a di- or oligopeptide, R.sup.1 is lower alkyl and X is a group which carries a charge or is polar at the pH values used for the reaction and which increases the solubility by a factor >5 compared with compounds wherein X=H, Q is the residue of an amino acid or of a di- or oligopeptide, and R.sup.2 is an optionally esterified or amidated acid group. In a preferred embodiment, the peptide or (.alpha.Type: GrantFiled: January 23, 1992Date of Patent: April 19, 1994Assignees: Forschungszentrum Juelich GmbH, Degussa AGInventors: Andreas Fischer, Alexander Schwarz, Christian Wandrey, Guenter Knaup, Andreas Bommarius, Karl-Heinz Drauz