Patents by Inventor Guenter Knaup

Guenter Knaup has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240409886
    Abstract: The present invention relates to a culture medium, preferably a cell culture medium, comprising at least one dipeptide, the dipeptide comprising asparagine (Asn) and glutamine (Gln). The invention further relates to the use of a culture medium of the invention for culturing cells, preferably plant cells, animal cells or mammalian cells. Another aspect of the invention relates to a method of manufacturing a cell culture product comprising the steps of (i) providing a cell capable of producing said cell culture product; (ii) contacting said cell with a culture medium according to the invention; and (iii) obtaining said cell culture product from said culture medium or from said cell.
    Type: Application
    Filed: August 22, 2024
    Publication date: December 12, 2024
    Applicant: Evonik Operations GmbH
    Inventors: Friedhelm MERZ, Andreas KARAU, Thomas HERMANN, Guenter KNAUP
  • Patent number: 12115260
    Abstract: The present invention relates to a tablet comprising one or more omega-3 fatty acid amino acid salt(s), a method for preparing a tablet according to the invention and the use of a tablet according to the invention as a food supplement or as a pharmaceutical product.
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: October 15, 2024
    Assignee: Evonik Operations GmbH
    Inventors: Thomas Gottstein, Guenter Knaup, Michael Schwarm
  • Patent number: 11622952
    Abstract: The present invention relates to a tablet comprising one or more omega-3 fatty acid amino acid salts, a method for preparing a tablet according to the invention and the use of a tablet according to the invention as a food supplement or as a pharmaceutical product.
    Type: Grant
    Filed: August 15, 2018
    Date of Patent: April 11, 2023
    Assignee: Evonik Operations GmbH
    Inventors: Thomas Gottstein, Michael Schwarm, Guenter Knaup
  • Patent number: 11441119
    Abstract: Disclosed herein is a cell culture media containing L-glutamine from a set of N-acylated dipeptides Acyl-X-Q, and L-glutamine from a set of other glutamine-sources Qsource in a defined molar ratio R=n(Acyl-X-Q)/n(Qsource), wherein the variables X, Q, Acyl, R, n(Acyl-X-Q) and n(Qsource) are defined in the general disclosure. Processes of using the cell culture media are also described herein.
    Type: Grant
    Filed: March 2, 2018
    Date of Patent: September 13, 2022
    Assignee: Evonik Operations GmbH
    Inventors: Guenter Knaup, Friedhelm Merz
  • Patent number: 11219235
    Abstract: The present invention relates to a method for preparing a composition comprising one or more omega-3 fatty acid salt(s), the composition obtainable or obtained by this method, and also the use of this composition for the preparation of foodstuffs, food supplements or pharmaceutical products.
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: January 11, 2022
    Assignee: Evonik Operations GmbH
    Inventors: Guenter Knaup, Milan Latinovic, Joerg Lotz, Michael Schwarm
  • Publication number: 20210121429
    Abstract: The present invention relates to a tablet comprising one or more omega-3 fatty acid amino acid salts, a method for preparing a tablet according to the invention and the use of a tablet according to the invention as a food supplement or as a pharmaceutical product.
    Type: Application
    Filed: August 15, 2018
    Publication date: April 29, 2021
    Applicant: Evonik Operations GmbH
    Inventors: Thomas GOTTSTEIN, Michael SCHWARM, Guenter KNAUP
  • Publication number: 20200315230
    Abstract: The present invention relates to a method for preparing a composition comprising one or more omega-3 fatty acid salt(s), the composition obtainable or obtained by this method, and also the use of this composition for the preparation of foodstuffs, food supplements or pharmaceutical products.
    Type: Application
    Filed: May 24, 2017
    Publication date: October 8, 2020
    Applicant: EVONIK TECHNOCHEMIE GMBH
    Inventors: Guenter KNAUP, Milan LATINOVIC, Jörg LOTZ, Michael SCHWARM
  • Publication number: 20200315970
    Abstract: The present invention relates to a tablet comprising one or more omega-3 fatty acid amino acid salt(s), a method for preparing a tablet according to the invention and the use of a tablet according to the invention as a food supplement or as a pharmaceutical product.
    Type: Application
    Filed: May 24, 2017
    Publication date: October 8, 2020
    Applicant: Evonik Technochemie GmbH
    Inventors: Thomas GOTTSTEIN, Guenter KNAUP, Michael SCHWARM
  • Publication number: 20200024571
    Abstract: Disclosed herein is a cell culture media containing L-glutamine from a set of N-acylated dipeptides Acyl-X-Q, and L-glutamine from a set of other glutamine-sources Qsource in a defined molar ratio R=n(Acyl-X-Q)/n(Qsource), wherein the variables X, Q, Acyl, R, n(Acyl-X-Q) and n(Qsource) are defined in the general disclosure. Processes of using the cell culture media are also described herein.
    Type: Application
    Filed: March 2, 2018
    Publication date: January 23, 2020
    Applicant: Evonik Degussa GmbH
    Inventors: Guenter KNAUP, Friedhelm MERZ
  • Publication number: 20200010796
    Abstract: The present invention relates to a culture medium, preferably a cell culture medium, comprising at least one dipeptide, the dipeptide comprising asparagine (Asn) and glutamine (Gln). The invention further relates to the use of a culture medium of the invention for culturing cells, preferably plant cells, animal cells or mammalian cells. Another aspect of the invention relates to a method of manufacturing a cell culture product comprising the steps of (i) providing a cell capable of producing said cell culture product; (ii) contacting said cell with a culture medium according to the invention; and (iii) obtaining said cell culture product from said culture medium or from said cell.
    Type: Application
    Filed: March 2, 2018
    Publication date: January 9, 2020
    Applicant: Evonik Degussa GmbH
    Inventors: Friedhelm MERZ, Andreas KARAU, Thomas HERMANN, Guenter KNAUP
  • Publication number: 20190390161
    Abstract: The invention relates to a culture medium containing at least one oligopeptide of 2-10 amino acids in length. The amino acids are natural amino acids. At least one of the amino acids is lysine; and one further is cysteine, cystine, leucine, tyrosine, valine, or Isoleucine. The oligopeptide is present in an amount of at least 0.1 mM. The invention also relates to the use of the culture medium for culturing cells, preferably plant cells, animal cells or mammalian cells. The invention further relates to a method of manufacturing a cell culture product including the steps of (i) providing a cell capable of producing the cell culture product; (ii) contacting the cell with the culture medium, and (iii) obtaining the cell culture product from the culture medium or from the cell.
    Type: Application
    Filed: March 2, 2018
    Publication date: December 26, 2019
    Applicant: Evonik Degussa GmbH
    Inventors: Guenter KNAUP, Friedhelm MERZ, Christian KESSLER
  • Publication number: 20170367394
    Abstract: A processes for increasing the stability of a composition containing polyunsaturated an omega-6 fatty acid against oxidation proceeds by (i) providing a starting composition containing at least one polyunsaturated omega-6 fatty acid component; (ii) providing a lysine composition; (iii) admixing an aqueous, an aqueous-alcoholic or an alcoholic solution of starting composition and lysine composition, and subjecting a resulting admixture to spray drying conditions subsequently, thus forming a solid product composition containing at least one salt of a cation derived from lysine with an anion derived from the polyunsaturated omega-6 fatty acid; the product composition exhibiting a solvent content SC selected from the following; SC<5 wt %, SC<3 wt %, SC<1 wt %, or <0.5 wt %.
    Type: Application
    Filed: December 17, 2015
    Publication date: December 28, 2017
    Applicant: Evonik Degussa GmbH
    Inventors: Guenter KNAUP, Milan LATINOVIC, Michael SCHWARM
  • Publication number: 20170360072
    Abstract: A process for increasing the stability of a composition containing a polyunsaturated omega-3 fatty acid against oxidation proceeds by (i) providing a starting composition containing at least one polyunsaturated omega-3 fatty acid component; (ii) providing a lysine composition; (iii) admixing an aqueous, an aqueous-alcoholic or an alcoholic solution of starting composition and lysine composition, and subjecting resulting admixture to spray drying conditions subsequently, thus forming a solid product composition containing at least one salt of a cation derived from lysine with an anion derived from a polyunsaturated omega-3 fatty acid; the product composition exhibiting a solvent content SC selected from the following: SC<5 wt %, SC<3 wt %, SC<1 wt %, or SC<0.5 wt %.
    Type: Application
    Filed: December 17, 2015
    Publication date: December 21, 2017
    Applicant: Evonik Degussa GmbH
    Inventors: Guenter KNAUP, Milan LATINOVIC, Michael SCHWARM
  • Patent number: 6830692
    Abstract: The invention relates to a special amino acid mixture for hemodialysis as well as to the dialysis solution that can be prepared from the amino acid mixture. When the amino acid mixtures according to the invention are used for such purposes, the “shrinking men” phenomenon cam be prevented. The present invention also relates to a hemodialysis process and apparatus. This aspect of the invention provides a closed dialysis system with a dialyzer solution containing the amino acid mixtures according to the invention.
    Type: Grant
    Filed: September 20, 1999
    Date of Patent: December 14, 2004
    Assignee: Degussa AG
    Inventors: Karlheinz Drauz, Guenter Knaup, Gerard Richet, Werner Kleophas, Adolf Gruenert
  • Patent number: 6787039
    Abstract: The invention relates to a special amino acid mixture for hemodialysis as well as to the dialysis solution that can be prepared from the amino acid mixture. When the amino acid mixtures according to the invention are used for such purposes, the “shrinking men” phenomenon can be prevented. The present invention also relates to a hemodialysis process and apparatus. This aspect of the invention provides a closed dialysis system with a dialyzer solution containing the amino acid mixtures according to the invention.
    Type: Grant
    Filed: January 26, 2001
    Date of Patent: September 7, 2004
    Assignee: Degussa AG
    Inventors: Karlheinz Drauz, Guenter Knaup, Gerard Richet, Werner Kleophas, Adolf Gruenert
  • Patent number: 6673942
    Abstract: The present invention relates to a process for the resolution of DL-racemic mixtures of compounds which crystalize in the form of a conglumerate. Both, the D and L-enantiomers are obtained according to the invention in a industrially feasable process by adding chiral enantioselective polymers to the supersaturated solution of the racemat to inhibit crystalization of one enantiomer. Next a DL-racemic mixture of said compound is suspended in about twice the amount of the crystallized enantiomer. Consequently, the opposite enantiomer could be recovered by said suspension by physical separation.
    Type: Grant
    Filed: July 23, 2002
    Date of Patent: January 6, 2004
    Assignees: Degussa AG, Yeda Research and Development Co., Ltd.
    Inventors: Matthias Kottenhahn, Guenter Knaup, Karlheinz Drauz, Meir Lahav, David Zbaida
  • Publication number: 20020144946
    Abstract: An amino acid composition suitable for hemodialysis and a dialysis solution that can be prepared from the amino acid mixture. When the inventive amino acid composition is used for this purpose, the “shrinking men” phenomenon can be prevented. Also provides are a hemodialysis process and apparatus.
    Type: Application
    Filed: January 26, 2001
    Publication date: October 10, 2002
    Inventors: Karlheinz Drauz, Guenter Knaup, Gerard Richet, Werner Kleophas, Adolf Gruenert
  • Patent number: 5304470
    Abstract: Protected and unprotected di- or oligopeptides are synthesized by reacting an N-terminally protected .alpha.-amino acid alkyl ester or peptide alkyl ester of the formula X--E--R.sup.1 with an amino acid or a di- or oligopeptide or a derivative thereof of the formula H.sub.2 N--Q--R.sup.2 in aqueous solution in the presence of a hydrolase, and, removing protective groups from the reaction product separated from the reaction mixture, where E is the residue of an .alpha.-amino acid or of a di- or oligopeptide, R.sup.1 is lower alkyl and X is a group which carries a charge or is polar at the pH values used for the reaction and which increases the solubility by a factor >5 compared with compounds wherein X=H, Q is the residue of an amino acid or of a di- or oligopeptide, and R.sup.2 is an optionally esterified or amidated acid group. In a preferred embodiment, the peptide or (.alpha.
    Type: Grant
    Filed: January 23, 1992
    Date of Patent: April 19, 1994
    Assignees: Forschungszentrum Juelich GmbH, Degussa AG
    Inventors: Andreas Fischer, Alexander Schwarz, Christian Wandrey, Guenter Knaup, Andreas Bommarius, Karl-Heinz Drauz