Patents by Inventor Guenter Linz

Guenter Linz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hydrates and polymorphs of 4-[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament
    Publication number: 20060035902
    Abstract: Disclosed are hydrates and polymorphs of 4-[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, processes for preparing them and their use as pharmaceutical compositions.
    Type: Application
    Filed: August 4, 2005
    Publication date: February 16, 2006
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Guenter Linz, Peter Sieger, Gerd Kraemer, Rolf Herter, Matthias Hoffmann, Werner Rall, Rolf Schmid
  • Pharmaceutical compositions containing tiotropium salts and low-solubility salmeterol salts
    Publication number: 20050256149
    Abstract: Pharmaceutical compositions and kits comprising: (a) a tiotropium salt; and (b) a salmeterol salt having a solubility in water of 0.1 mg/mL or less, processes for preparing them, and their use in the treatment of respiratory complaints, asthma, and chronic obstructive pulmonary disease (COPD).
    Type: Application
    Filed: February 11, 2005
    Publication date: November 17, 2005
    Applicant: Boehringer Ingelheim Pharma KG
    Inventors: Guenter Linz, Rainer Soyka
  • Process for preparing 1- [N²-[3,5-dibromo-N-[[4-(3,4-dihydro-2(1H)-oxoquinazolin-3-yl)-1-piperidinyl]carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyridinyl)-piperazine
    Publication number: 20050192230
    Abstract: The present application relates to a process for preparing the CGRP-antagonist 1-[N2-[3,5-dibromo-N-[[4-(3,4-dihydro-2(1H)-oxoquinazolin-3-yl)-1-piperidinyl]carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyridinyl)-piperazine of formula by means of which this compound can be prepared in large amounts, in high yields and with high purity.
    Type: Application
    Filed: January 20, 2005
    Publication date: September 1, 2005
    Applicant: Boehringer Ingelheim International GambH
    Inventors: Guenter Linz, Wolfgang Broeder, Georg Zerban, Eric Winter, Bernd Schmitt, Svenja Renner, Bjoern Weyell, Heinz-Peter Schmitt
  • Pharmaceutical compositions containing tiotropium salts and low-solubility salmeterol salts
    Patent number: 6919325
    Abstract: Pharmaceutical compositions and kits comprising: (a) a tiotropium salt; and (b) a salmeterol salt having a solubility in water of 0.1 mg/mL or less, processes for preparing them, and their use in the treatment of respiratory complaints, asthma, and chronic obstructive pulmonary disease (COPD).
    Type: Grant
    Filed: September 5, 2002
    Date of Patent: July 19, 2005
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Guenter Linz, Rainer Soyka
  • 3-Z-[1-(4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone-monoethanesulphonate and the use thereof as a pharmaceutical composition
    Publication number: 20040176392
    Abstract: The present invention relates to the compound 3-Z-[1-(4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone-monoethanesulphonate of formula I and the use thereof as a pharmaceutical composition.
    Type: Application
    Filed: July 21, 2003
    Publication date: September 9, 2004
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Gerald J. Roth, Guenter Linz, Peter Sieger, Werner Rall, Frank Hilberg, Thomas Bock
  • Cinnamic acid salts, processes for their preparation, and their use as medicaments
    Patent number: 6756508
    Abstract: The present invention relates to new cinnamic acid salts of salmeterol, processes for the preparation thereof as well as the use thereof as pharmaceutical compositions.
    Type: Grant
    Filed: February 13, 2003
    Date of Patent: June 29, 2004
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Guenter Linz, Rainer Soyka
  • Salicylic acid salts of salmeterol
    Patent number: 6680345
    Abstract: The present invention relates to new substituted salicylic acid salts of salmeterol, processes for preparing them and their use
    Type: Grant
    Filed: September 12, 2002
    Date of Patent: January 20, 2004
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Guenter Linz, Rainer Soyka, André Steiner
  • (R) 2-(4-amidinophenylaminomethyl)-1-methyl-5-[1-(carboxymethylamino)-1 (pyrrolidinocarbonyl)-ethyl]-benzimidazole, the monohydrochloride thereof, preparation thereof and the use as pharmaceutical composition
    Publication number: 20040010026
    Abstract: Crystalline forms of the compounds (R)-2-(4-amidinophenylaminomethyl)-1-methyl-5-[1-(carboxymethylamino)-1-(pyrrolidinocarbonyl)-ethyl]-benzimidazole and the monohydrochloride thereof, processes for the preparation thereof and the use thereof as pharmaceutical compositions.
    Type: Application
    Filed: June 17, 2003
    Publication date: January 15, 2004
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Guenter Linz, Peter Sieger, Gunnar Schreiner, Werner Rall, Rolf Schmid
  • Cinnamaic acid salts, processes for the preparation thereof and use thereof as medicament
    Publication number: 20030166722
    Abstract: The present invention relates to new cinnamic acid salts of salmeterol, processes for the preparation thereof as well as the use thereof as pharmaceutical compositions.
    Type: Application
    Filed: February 13, 2003
    Publication date: September 4, 2003
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Guenter Linz, Rainer Soyka
  • Pharmaceutical compositions containing tiotropium salts and low-solubility salmeterol salts
    Publication number: 20030130300
    Abstract: Pharmaceutical compositions and kits comprising:
    Type: Application
    Filed: September 5, 2002
    Publication date: July 10, 2003
    Applicant: Boehringer Ingelheim Pharma KG
    Inventors: Guenter Linz, Rainer Soyka
  • Salicylic acid salts of salmeterol
    Publication number: 20030069310
    Abstract: The present invention relates to new substituted salicylic acid salts of salmeterol, processes for preparing them and their use
    Type: Application
    Filed: September 12, 2002
    Publication date: April 10, 2003
    Applicant: Boehringer Ingelheim Pharma KG
    Inventors: Guenter Linz, Rainer Soyka, Andre Steiner
  • Cyclic urea derivatives, pharmaceutical compositions containing these compounds and processes for preparing them
    Patent number: 5852192
    Abstract: The invention relates to cyclic urea derivatives of general formula ##STR1## wherein R.sub.a, R.sub.b, X and Y are as defined herein, pharmaceutical compositions containing the derivatives and processes for preparing them.
    Type: Grant
    Filed: May 1, 1997
    Date of Patent: December 22, 1998
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Frank Himmelsbach, Helmut Pieper, Volkhard Austel, Guenter Linz, Johannes Weisenberger, Wolfgang Eisert, Thomas Mueller
  • Cyclic urea derivatives, pharmaceutical compositions containing these compounds and processes for preparing them
    Patent number: 5650424
    Abstract: The invention relates to cyclic urea derivatives of general formula ##STR1## wherein R.sub.a, R.sub.b, X and Y are as defined herein, pharmaceutical compositions containing the derivatives and processes for preparing them.
    Type: Grant
    Filed: August 29, 1995
    Date of Patent: July 22, 1997
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Frank Himmelsbach, Helmut Pieper, Volkhard Austel, Guenter Linz, Thomas Mueller, Johannes Weisenberger, Wolfgang Eisert
  • Cyclic imino derivatives and pharmaceutical compositions containing them
    Patent number: 5591769
    Abstract: The invention relates to cyclic imino compounds which have, inter alia, valuable pharmacological properties, especially inhibitory effects on cell aggregation, pharmaceutical compositions which contain these compounds and processes for preparing them.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: January 7, 1997
    Assignee: Karl Thomae GmbH
    Inventors: Frank Himmelsbach, Volkhard Austel, Helmut Pieper, Wolfgang Eisert, Thomas Mueller, Johannes Weisenberger, Guenter Linz, Gerd Krueger
  • Cyclic imino derivatives, processes for preparing them and pharmaceutical compositions containing these compounds
    Patent number: 5576444
    Abstract: Cyclic imino derivatives of the formulaB--X.sub.2 --X.sub.1 --A--Y--E (I)wherein A, B, E, X.sub.1, X.sub.2 and Y are as defined herein, the stereoisomers, tautomers, mixtures and addition salts thereof, pharmaceutical compositions containing these compounds and processes for preparing them. The cyclic imino derivatives are useful as inhibitors of cell-cell and cell-matrix interactions, e.g., thrombocyte aggregation.
    Type: Grant
    Filed: April 26, 1993
    Date of Patent: November 19, 1996
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Frank Himmelsbach, Austel Volkhard, Helmut Pieper, Guenter Linz, Johannes Weisenberger, Thomas Mueller
  • Heterobiaryl derivatives
    Patent number: 5563268
    Abstract: Heterobiaryl derivatives of the formulaR.sub.1 NH--X.sub.1 --X.sub.2 --X.sub.3 --Y.sub.1 --Y.sub.2 --Y.sub.3 --Y.sub.4 --E (I)whereinR.sub.1, X.sub.1 to X.sub.3 and Y.sub.1 to Y.sub.4 are as defined herein, the tautomers, stereoisomers and mixtures thereof, and the salts, particularly the physiologically acceptable salts, thereof with organic or inorganic acids or bases. The derivatives have valuable pharmacological properties, such as inhibiting cell-cell aggregation and cell-matrix interactions.
    Type: Grant
    Filed: January 19, 1995
    Date of Patent: October 8, 1996
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Guenter Linz, Helmut Pieper, Frank Himmelsbach, Volkhard Austel, Thomas Mueller, Johannes Weisenberger, Elke Seewaldt-Becker
  • Cyclic imino derivatives and pharmaceutical compositions containing them
    Patent number: 5541343
    Abstract: The invention relates to cyclic imino compounds which have, inter alia, valuable pharmacological properties, especially inhibitory effects on cell aggregation, pharmaceutical compositions which contain these compounds and processes for preparing them.
    Type: Grant
    Filed: December 28, 1994
    Date of Patent: July 30, 1996
    Assignee: Karl Thomae GmbH
    Inventors: Frank Himmelsbach, Volkhard Austel, Helmut Pieper, Wolfgang Eisert, Thomas Mueller, Johannes Weisenberger, Guenter Linz, Gerd Krueger
  • Cyclic imino derivatives, pharmaceutical compositions containing these compounds and processes preparing them
    Patent number: 5489693
    Abstract: Cyclic imino derivatives of the formula ##STR1## wherein X and R.sub.a to R.sub.g are as defined herein, useful for their inhibitory effects on aggregation, pharmaceutical compositions containing the compounds and processes for preparing them.
    Type: Grant
    Filed: April 26, 1993
    Date of Patent: February 6, 1996
    Inventors: Guenter Linz, Volkhard Austel, Frank Himmelsbach, Johannes Weisenberger, Thomas Mueller, Helmut Pieper, Elke Seewaldt-Becker
  • Cyclic urea derivatives and pharmaceutical compositions containing these compounds
    Patent number: 5478942
    Abstract: The invention relates to cyclic urea derivatives of general formula ##STR1## wherein R.sub.a, R.sub.b, X and Y are as defined herein, pharmaceutical compositions containing the derivatives and processes for preparing them.
    Type: Grant
    Filed: October 28, 1993
    Date of Patent: December 26, 1995
    Assignee: Karl Thomae GmbH
    Inventors: Frank Himmelsbach, Helmut Pieper, Volkhard Austel, Guenter Linz, Thomas Mueller, Johannes Weisenberger, Wolfgang Eisert
  • 5-membered heterocyclic compounds, processes for preparing them and pharmaceutical compositions containing these compounds
    Patent number: 5463071
    Abstract: Compounds of the formula ##STR1## wherein X.sub.1 to X.sub.5 are as defined herein, the tautomers, the stereoisomers including the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases. The compounds are useful for inhibiting undesirable cell aggregation.
    Type: Grant
    Filed: November 8, 1993
    Date of Patent: October 31, 1995
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Frank Himmelsbach, Guenter Linz, Volkhard Austel, Helmut Pieper, Thomas Mueller, Johannes Weisenberger, Elke Seewaldt-Becker