Abstract: A 3D micro flow cell is fabricated by forming a first spacer on a substrate to define the flow channel of the cell extending between inlet and outlet openings. A second spacer, comprising a pasty adhesive is applied outside the first spacer or in a groove on the first spacer to seal the cell when the first substrate is joined to a second substrate.

Abstract: A method for detecting the binding between binding sites, comprising the following steps: providing a population of nanoparticles N1, . . . Nx, each nanoparticle having at least one characteristic electrical field property and at least one first binding site, wherein the characteristic electrical field property codes for the corresponding first binding site of each nanoparticle, adding a sample to be analyzed which possibly comprises at least oen analyte with at least one second binding site capable to bind to said first binding site, wherein said analyte and/or said nanoparticles N1, . . . or Nx have at least one detectable property which changes upon binding of said first binding site to said second binding site, the detectable property being different from the electrical field property, applying an electrical field, separating said population of nanoparticles with regard to said electrical field property, measuring the presence or absence of a change of the at least one detectable property.

Abstract: A 3D micro flow cell is fabricated by forming a first spacer on a substrate to define the flow channel of the cell extending between inlet and outlet openings. A second spacer, comprising a pasty adhesive is applied outside the first spacer or in a groove on the first spacer to seal the cell when the first substrate is joined to a second substrate.