Patents by Inventor Guenther Knebel

Guenther Knebel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20130237443
    Abstract: A process for the production of a reaction chamber assembly, wherein a flat substrate and bottomless reaction chambers are provided, the substrate is first loaded with a biological agent and then the bottomless reaction chambers are bonded glue-free to the substrate, in particular through laser bonding, and liquid-tight reaction chambers, for instance individual wells, individually connected wells, such as strips, or wells in the form of a microtiter plate, are obtained. The present invention further provides a kit comprising a substrate suitable for being loaded with at least one biological agent and at least one bottomless reaction chamber, wherein the kit is suitable for glue-free bonding of the bottomless reaction chamber to the substrate.
    Type: Application
    Filed: March 6, 2013
    Publication date: September 12, 2013
    Applicants: SCIENION AG, GREINER BIO-ONE GMBH
    Inventors: Guenther KNEBEL, Holger EICKHOFF
  • Patent number: 8512652
    Abstract: The present invention relates to an improved microplate which is constructed of at least one frame part and at least one bottom part, where the bottom part has a maximum thickness of 500 ?m.
    Type: Grant
    Filed: October 15, 2002
    Date of Patent: August 20, 2013
    Assignee: Greiner Bio-One GmbH
    Inventors: Günther Knebel, Martin Bechem, Werner Stürmer, Ralph Noll
  • Patent number: 8007744
    Abstract: The present invention relates to a sample container for analyses suitable for medical diagnostics comprising a platform plate having at least one reaction chamber. The reaction chamber has a bottom and a sidewall which form a three-dimensional chamber which is open in the upward direction. The ratio of the numerical value of the surface area of the bottom is relatively large relative to the height of the sidewall. The ratio may be greater than or equal to 30, 35, 40, 45, 50, 60, 70, 80, or 90. The reaction chamber further comprises a binding area on an internal surface of the reaction chamber which may be functionalized for binding at least one chemical entity for use in an assay.
    Type: Grant
    Filed: January 16, 2004
    Date of Patent: August 30, 2011
    Assignee: Greiner Bio-One GmbH
    Inventors: Günther Knebel, Jörg Stappert, Heinrich Jehle, Joachim Kessler
  • Publication number: 20110111504
    Abstract: The invention relates to a bioreactor (1) for cell and tissue culture for the mechanical stimulation and for perfusion of tissue or cell cultures, comprising an upper part (3) and a lower part (4) which is connected to said upper part (4) and which comprises a tissue culture chamber (8), wherein at least one distributor plate (12) is arranged in the tissue culture chamber (8), and a method for cultivating cells and tissues in the bioreactor (1).
    Type: Application
    Filed: May 25, 2009
    Publication date: May 12, 2011
    Applicant: Greiner Bio - One GmbH
    Inventors: Guenther Knebel, Sven Muehlfriedel
  • Patent number: 7534396
    Abstract: The invention relates to a container (1) with a base body (2), comprising a base plate (3) and side walls (4) standing out therefrom in an at least approximately perpendicular arrangement, and with wells (5) disposed in the base body (2). The wells (5) are provided in the form of a recess in the base plate (3) and the side walls (4) of the base plate (3) are disposed in at least the approximately opposite direction from the recesses in order to accommodate a volume.
    Type: Grant
    Filed: April 29, 2003
    Date of Patent: May 19, 2009
    Assignee: Greiner Bio-One GmbH
    Inventors: Günther Knebel, Allan D'Arcy, Robert Earl Cudney
  • Patent number: 7005008
    Abstract: The invention relates to a reaction vessel (1) for producing a sample, in particular a crystal, from a substance in solution or in liquid form, having several reaction chambers (6) each forming a separate gas chamber, consisting of at least one housing part, and each reaction chamber (6) has a reservoir (7) and several reaction areas (8) co-operating therewith, connected to one another and to the reservoir (7) in order to exchange gas. The reservoirs and the reaction areas co-operating with them are disposed immediately adjacent to one another in rows, distributed in a predeterminable, identical manner, these rows running parallel with one another. Each row of reservoirs (7) therefore co-operates with at least one row of reaction areas (8).
    Type: Grant
    Filed: June 18, 2001
    Date of Patent: February 28, 2006
    Assignees: Greiner Bio-One GmbH, Max-Planck-Gesellschaft zur Förderung der Wissenschaft e.V.
    Inventors: Günther Knebel, Lajos Nyársik, Holger Friedrich Heinrich Eickhoff, Hans Lehrach
  • Patent number: 6835293
    Abstract: The invention relates to an analysis system comprising a main body (1) with a surface, at least one analysis unit (6) consisting of at least two reservoirs (10) placed in flow connection by at least one passage (13, 14) being provided in the main body (1). Two electrical conductors (23, 24) are provided in the main body (1) or on the surface, a first respective end region thereof being connected respectively to one of the at least two reservoirs (10) and a respective second end region of the conductors (23, 24) being connected to or constituting a contact point (9) on the surface of the main body (1).
    Type: Grant
    Filed: July 9, 2001
    Date of Patent: December 28, 2004
    Assignee: Greiner Bio-One GmbH
    Inventors: Andreas Gerlach, Günther Knebel
  • Patent number: 6514464
    Abstract: The present invention relates to an improved microplate which is constructed of at least one frame part and at least one bottom part, where the bottom part has a thickness of 500 &mgr;m.
    Type: Grant
    Filed: July 23, 1997
    Date of Patent: February 4, 2003
    Assignee: Greiner Bio-One GmbH
    Inventor: Günther Knebel
  • Patent number: 6503456
    Abstract: The present invention relates to an improved microplate, which is constructed from at least one frame part and at least one base part, the base part having a thickness of at most 500 &mgr;m.
    Type: Grant
    Filed: November 2, 1999
    Date of Patent: January 7, 2003
    Assignee: Greiner Bio-One GmbH
    Inventor: Günther Knebel