Abstract: The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted melittin delivery peptides. Delivery peptides provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery peptides.

Abstract: The present invention relates to electrodeposition primer compositions comprising catalytically active core/shell particles CS . The electrodeposition primer compositions can be used more particularly for cathodic dip coating for the coating of automobile bodies or parts thereof.

Abstract: Film-forming materials include nonionic metal coordinating structures. Nonionic metal coordinating structures can coordinate metals, such as metal catalysts and metal substrates. Example film-forming materials can be the product of a poly-functional epoxide and a nucleophilic ligand having a nonionic metal coordinating structure, or the product of a poly-functional alcohol and an electrophilic ligand having a nonionic metal coordinating structure. Coating compositions can include the film-forming material and a crosslinker. The coating compositions can be used to coat a substrate, such as a metal substrate. Applied coating layers on substrates can be cured to form coating films.

Abstract: A crosslinker for polymerizing a film-forming material including an alkyl or aromatic compound comprising at least two functional groups reactive with a film-forming resin and at least one pendent group having a nonionic metal coordinating structure. Coating compositions can include a film-forming material and the crosslinker. The coating compositions can be used to coat a substrate, such as a metal substrate. Applied coating layers on substrates can be cured to form coating films.

Abstract: Film-forming materials include nonionic metal coordinating structures. Nonionic metal coordinating structures can coordinate metals, such as metal catalysts and metal substrates. Example film-forming materials can be the product of a poly-functional epoxide and a nucleophilic ligand having a nonionic metal coordinating structure, or the product of a poly-functional alcohol and an electrophilic ligand having a nonionic metal coordinating structure.

Abstract: Electrocoat material comprising bismuth compounds, comprising: (A) at least one self-crosslinking and/or externally crosslinking binder containing(potentially) cationic or anionic groups and reactive functional groups which (i) with themselves or with complementary reactive functional groups in the self-crosslinking binder, or (ii) in the case of the externally crosslinking binder, with complementary reactive functional groups present in crosslinking agents (B) are able to undergo thermal crosslinking reactions, (B) if desired, at least one crosslinking agent comprising the complementary reactive functional groups, and (C) at least one bismuth compound.

Abstract: Powder slurries curable thermally and with actinic radiation and comprising solid and/or highly viscous particles dimensionally stable under storage and application conditions, comprising (A) a binder free of carbon-carbon double bonds activatable with actinic radiation, comprising at least one (meth)acrylate copolymer containing on average per molecule at least one isocyanate-reactive functional group and at least one ion-forming group, (B) at least one blocked and/or part-blocked polyisocyanate, and (C) at least one olefinically unsaturated constituent which is free of isocyanate-reactive functional groups and contains on average per molecule more than four carbon-carbon double bonds activatable with actinic radiation; processes for preparing them, and their use.

Abstract: A pseudoplastic clearcoat slurry comprising solid and/or highly viscous particles which are dimensionally stable under storage and application conditions and at least one water soluble salt, preferably from 0.1 to 50 mmol per 1 000 g of water, which can be decomposed without residue or virtually without residue; process for preparing it, and its use.

Abstract: The invention relates to a powder-slurry that can be hardened by actinic radiation or by thermal means, comprising (I) components containing functional groups (A) which render them hardenable by actinic radiation and components containing complementary functional groups (B) which render them thermally hardenable, in a weight ratio of 50:1 to 1:50 and/or comprising (II) components containing the functional groups (A) and (B) which render them thermally hardenable and hardenable by actinic radiation in a molar ratio of 100:1 to 1:100.

Abstract: A pseudoplastic powder clearcoat slurry free from organic solvents and external emulsifiers and comprising particles which are solid and/or of high viscosity and are dimensionally stable under storage and application conditions, where the particles have an average size of from 1.0 to 20 ?m, at least 99% of the particles having a size ?30 ?m, and comprise as binder at least one polyol with an OH number >110 mg KOH/g, containing potentially ionic groups, and where the powder clearcoat slurry has a potentially ionic group content of from 0.05 to 1 meq/g of solids, at a degree of neutralization of not more than 50% contains from 0.005 to 0.1 meq/g of solids of ionic groups produced by neutralization of the potentially ionic groups, and has a viscosity of (i) from 50 to 1 000 mPas at a shear rate of 1 000 s?1, (ii) from 150 to 8 000 mPas at a shear rate of 10 s?1, and (iii) from 180 to 12 000 mPas at a shear rate of 1 s?1.

Abstract: A pseudoplastic powder clearcoat slurry which is free from organic solvents and comprises solid and/or highly viscous, particles which are dimensionally stable under storage and application conditions and have an average size of from 0.8 to 20 ?m, at least 99% of the particles having a size ?30 ?m, which is preparable by 1) emulsifying an organic solution comprising binder and crosslinking agent to give an emulsion of the oil-in-water type, 2) removing the organic solvent or solvents, and 3) wet grinding the resulting slurry; and also the use of the powder clearcoat slurry to produce clearcoats for automotive OEM finishing and automotive refinish, for furniture coating and for industrial coating, including coil coating, container coating and the coating of electrical components.

Abstract: The present invention relates to a process for producing single-coat or multicoat clearcoat finishes on primed or unprimed substrates by applying at least one powder coating dispersion, in particular a powder clearcoat slurry, to the substrate and then curing the resulting film(s) thermally and/or with actinic radiation, in which oxalic acid is added to at least one powder coating dispersion, in particular to a powder clearcoat slurry.

Abstract: The invention relates to an intrinsically viscous powder-slurry that can hardened by actinic radiation or optionally by thermal means, which contains solid spherical particles with an average particle size of 0.8 to 20 &mgr;m and a maximum particle size of 30 &mgr;m. The clear powder coating slurry contains 0.05 to 1 meq/g of ion-forming groups and 0.05 to 1 meq/g of neutralizing agents and has a viscosity of (i) 50 to 1000 mPas at a shear rate of 1000 s−1, (ii) 150 to 8000 mPas at a shear rate of 10 s−1, and (iii) from 180 to 12000 mPas at a shear rate of 1 s−1.

Abstract: A pseudoplastic powder clearcoat slurry which is free from organic solvents and external emulsifiers and comprises solid spherical particles with an average size of from 0.8 to 20 &mgr;m and a maximum size of 30 &mgr;m, at least one ionic thickener and at least one nonionic associative thickener, the powder clearcoat slurry having an ion-forming group content of from 0.05 to 1 meq/g, a neutralizing agent content of from 0.05 to 1 meq/g, and a viscosity of (i) from 50 to 1 500 mPas at a shear rate of 1 000 s−1, (ii) from 150 to 8 000 mPas at a shear rate of 10 s−1, and (iii) from 180 to 12 000 mPas at a shear rate of 1 s−1.

Abstract: Novel powder clearcoat materials and novel powder clearcoat slurries comprising a) at least one epoxide-containing binder containing from 0.5 to 40% by weight, based on the binder, of copolymerized glycidyl-containing monomers, and b) at least one tris(alkoxy-carbonylamino)triazine and at least one polycarboxylic acid, in particular a straight-chain dicarboxylic acid, and/or a carboxy-functional polyester as crosslinking agent, or alternatively a) at least one tris(alkoxy-carbonylamino)triazine and at least one oligomeric or polymeric, epoxide-containing crosslinking agent containing from 0.5 to 40% by weight, based on the crosslinking agent, of copolymerized glycidyl-containing monomers, and/or a low molecular mass, epoxide-containing crosslinking agent, and b) at least one carboxyl-containing polymer as binder, both variants comprising c) at least one polyol.

Abstract: The present invention relates to a process for producing single-coat or multicoat clearcoat finishes on primed or unprimed substrates by applying at least one powder coating dispersion, in particular a powder clearcoat slurry, to the substrate and then curing the resulting film(s) thermally and/or with actinic radiation, in which at least one polyvalent inorganic acid and/or oxalic acid are or is added to at least one powder coating dispersion, in particular to a powder clearcoat slurry.

Abstract: The present invention relates to an aqueous dispersion comprising a solid pulverulent component A and an aqueous component B, said component A comprising a UV-curable powder coating material.

Abstract: The present invention relates to a method of coating substrates, preferably of metal, by cleaning the substrate surface, applying, if desired, an organic and/or inorganic pretreatment composition, applying a primer, applying a coating material by spraying, dipping, knifecoating, rollercoating or brushing, the coating material comprising an amine-modified epoxy resin and a crosslinking agent suitable for crosslinking.

Abstract: The present invention relates to an aqueous binder dispersion for cathodic electrodeposition coatings obtained A) by reacting I. a precursor prepared at temperatures of from 120 to 180° C. from a) a diepoxide compound or a mixture of diepoxide compounds and b) an aromatic or aliphatic compound hydroxyl, carboxyl, phenol and/or thiol groups, or a mixture of such compounds with reaction of the phenolic hydroxyl groups with epoxide groups, II. with at least one organic amine or a mixture of organic amines at a temperature between 60 and about 130° C. to give an epoxide/amine adduct; B) subsequently or simultaneously reacting at least one secondary hydroxyl group of the precursor with an unreacted epoxide group of the epoxide/amine adduct prepared in step A) at a temperatures of from about 110 to about 150° C.; C) adding a crosslinking agent at a temperature of less than about 150° C.

Abstract: The invention relates to a process for preparing a binder for electrodeposition coating compositions comprising providing: (A) from 1 to 99.9% by weight of an epoxy resin and (B) from 0.1 to 99.% by weight of a copolymer of vinyl acetate and at least one further component selected from the group vinyl alcohol, alkyl-vinyl acetal and ethylene, characterized in that components (A) and (B) of the binder are mixed intensively in a solvent or in the melt before being used in the coating composition, preferably in the presence of epoxy ring-opening catalysts.