Patents by Inventor Guenther Walther

Guenther Walther has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Systems and methods for cluster matching across samples and guided visualization of multidimensional cytometry data
    Patent number: 10685045
    Abstract: Some embodiments provide methods, systems and computer-readable media that employ adaptive binning and dissimilarity scores based on a quadratic form distance for multidimensional data for matching clusters in data corresponding to different sample. Some embodiments provide methods, systems and computer-readable media for rendering a first interactive display including a two-dimensional plot of at least a portion of a multidimensional data set and a corresponding second interactive display including a plurality of single parameter charts or histograms, each displaying information corresponding to one-dimensional measurements of a different parameter in the multidimensional data set.
    Type: Grant
    Filed: July 17, 2017
    Date of Patent: June 16, 2020
    Assignee: The Board of Trustees of The Leland Stanford Junior University
    Inventors: Darya Y. Orlova, Stephen W. Meehan, Wayne A. Moore, Guenther Walther, David R. Parks, Leonore A. Herzenberg, Connor Meehan
  • Cluster processing and ranking methods including methods applicable to clusters developed through density based merging
    Patent number: 10503756
    Abstract: The described invention provides a method and/or system for analyzing data using population clustering through density based merging, and a method for guiding clustering strategy through entropy-based ranking score.
    Type: Grant
    Filed: April 20, 2015
    Date of Patent: December 10, 2019
    Assignee: The Board of Trustees of The Leland Stanford Junior University
    Inventors: Stephen W. Meehan, Wayne A. Moore, Guenther Walther, Darya Orlova, Connor G. W. Meehan, David R. Parks, Leonore A. Herzenberg
  • FULLY AUTOMATED (UNSUPERVISED) IDENTIFICATION, MATCHING, DISPLAY AND QUANTITATION OF SUBSETS (CLUSTERS) BY EXHAUSTIVE PROJECTION PURSUIT METHODS
    Publication number: 20190360914
    Abstract: A method for defining distributions of functional subpopulations of cells in a cell population.
    Type: Application
    Filed: May 1, 2019
    Publication date: November 28, 2019
    Inventors: Stephen W. Meehan, Darya Y. Orlova, Wayne A. Moore, David R. Parks, Connor Meehan, Guenther Walther, Leonore A. Herzenberg
  • Quantitative comparison of sample populations using earth mover's distance
    Patent number: 10452746
    Abstract: A method and apparatus for quantitatively measuring differences between portions of a multivariate, multi-dimensional sample distribution, may comprise summarizing the data by dividing the data into clusters each having a signature representative of a position of the cluster and a fraction of the entire distribution within the cluster; matching a plurality of first supplier signatures to a respective one of a plurality of second receiver signatures using a cost factor indicative of the separation between first signature elements and second signature elements; and determining a measurement of the work required to transform the first signature to the second signature. The step of determining a measurement of the work may comprise applying the earth mover distance (“EMD”) algorithm between the first signature or elements of the first signature and the respective second signatures or elements of the respective second signature.
    Type: Grant
    Filed: January 3, 2012
    Date of Patent: October 22, 2019
    Assignee: The Board of Trustees of The Leland Stanford Junior University
    Inventors: Leonore A. Herzenberg, Guenther Walther, Wayne A. Moore, Noah Zimmerman
  • METHOD FOR IDENTIFYING CLUSTERS OF FLUORESCENCE-ACTIVATED CELL SORTING DATA POINTS
    Publication number: 20190050408
    Abstract: A method and/or system for analyzing data using population clustering through density based merging.
    Type: Application
    Filed: December 8, 2016
    Publication date: February 14, 2019
    Inventors: Guenther Walther, Ilana Belitskaya-Levy, Jinhui Pan, Leonore A. Herzenberg, Wayne Moore, David Parks
  • SYSTEMS AND METHODS FOR CLUSTER MATCHING ACROSS SAMPLES AND GUIDED VISUALIZATION OF MULTIDIMENSIONAL CYTOMETRY DATA
    Publication number: 20180018386
    Abstract: Some embodiments provide methods, systems and computer-readable media that employ adaptive binning and dissimilarity scores based on a quadratic form distance for multidimensional data for matching clusters in data corresponding to different sample. Some embodiments provide methods, systems and computer-readable media for rendering a first interactive display including a two-dimensional plot of at least a portion of a multidimensional data set and a corresponding second interactive display including a plurality of single parameter charts or histograms, each displaying information corresponding to one-dimensional measurements of a different parameter in the multidimensional data set.
    Type: Application
    Filed: July 17, 2017
    Publication date: January 18, 2018
    Inventors: Darya Y. Orlova, Stephen W. Meehan, Wayne A. Moore, Guenther Walther, David R. Parks, Leonore A. Herzenberg
  • METHOD FOR IDENTIFYING CLUSTERS OF FLUORESCENCE-ACTIVATED CELL SORTING DATA POINTS
    Publication number: 20170091199
    Abstract: A method and/or system for analyzing data using population clustering through density based merging.
    Type: Application
    Filed: December 8, 2016
    Publication date: March 30, 2017
    Inventors: Guenther Walther, Ilana Belitskaya-Levy, Jinjui Pan, Leonore A. Herzenberg, Wayne Moore, David Parks
  • A METHOD FOR IDENTIFYING CLUSTERS OF FLUORESCENCE-ACTIVATED CELL SORTING DATA POINTS
    Publication number: 20170091282
    Abstract: A method and/or system for analyzing data using population clustering through density based merging.
    Type: Application
    Filed: December 13, 2016
    Publication date: March 30, 2017
    Inventors: Guenther Walther, Ilana Belitskaya-Levy, Jinjui Pan, Leonore A. Herzenberg, Wayne Moore, David Parks
  • Method for identifying clusters of fluorescence-activated cell sorting data points
    Patent number: 9552416
    Abstract: A method and/or system for analyzing data using population clustering through density based merging.
    Type: Grant
    Filed: May 3, 2013
    Date of Patent: January 24, 2017
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Guenther Walther, Ilana Belitskaya-Levy, Jinhui Pan, Leonore A. Herzenberg, Wayne Moore, David Parks
  • CLUSTER PROCESSING AND RANKING METHODS INCLUDING METHODS APPLICABLE TO CLUSTER DEVELOPED THROUGH DENSITY BASED MERGING
    Publication number: 20150293992
    Abstract: The described invention provides a method and/or system for analyzing data using population clustering through density based merging, and a method for guiding clustering strategy through entropy-based ranking score.
    Type: Application
    Filed: April 20, 2015
    Publication date: October 15, 2015
    Inventors: Stephen W. Meehan, Wayne A. Moore, Guenther Walther, Darya Y. Orlova, Connor G.W. Meehan, David R. Parks, Leonore A. Herzenberg
  • POPULATION CLUSTERING THROUGH DENSITY BASED MERGING
    Publication number: 20130246434
    Abstract: A method and/or system for analyzing data using population clustering through density based merging.
    Type: Application
    Filed: May 3, 2013
    Publication date: September 19, 2013
    Inventors: Guenther Walther, IIana Belitskaya-Levy, Jinhui Pan, Leonore A. Herzenberg, Wayne Moore, David Parks
  • Method for clustering data items through distance-merging and density-merging techniques
    Patent number: 8473215
    Abstract: A method and/or system for analyzing data using population clustering through density based merging.
    Type: Grant
    Filed: April 26, 2004
    Date of Patent: June 25, 2013
    Assignee: Leland Stanford Junior University
    Inventors: Guenther Walther, Ilana Belitskaya-Levy, Jinhui Pan, Leonore A. Herzenberg, Wayne Moore, David Parks
  • Quantitative Comparison of Sample Populations Using Earth Mover's Distance
    Publication number: 20120173199
    Abstract: A method and apparatus for quantitatively measuring differences between portions of a multivariate, multi-dimensional sample distribution, may comprise summarizing the data by dividing the data into clusters each having a signature representative of a position of the cluster and a fraction of the entire distribution within the cluster; matching a plurality of first supplier signatures to a respective one of a plurality of second receiver signatures using a cost factor indicative of the separation between first signature elements and second signature elements; and determining a measurement of the work required to transform the first signature to the second signature. The step of determining a measurement of the work may comprise applying the earth mover distance (“EMD”) algorithm between the first signature or elements of the first signature and the respective second signatures or elements of the respective second signature.
    Type: Application
    Filed: January 3, 2012
    Publication date: July 5, 2012
    Inventors: Leonore A. Herzenberg, Guenther Walther, Wayne A. Moore, Noah Zimmerman
  • Population clustering through density-based merging
    Publication number: 20110029519
    Abstract: A method and/or system for analyzing data using population clustering through density based merging.
    Type: Application
    Filed: April 26, 2004
    Publication date: February 3, 2011
    Inventors: Guenther Walther, IIana Belitskaya-Levy, Jinhui Pan, Leonore A. Herzenberg, Wayne Moore, David Parks