Patents by Inventor Guey-Jen LEE-CHEN

Guey-Jen LEE-CHEN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10213470
    Abstract: The present invention relates to a method for treating spinocerebellar ataxias comprising administering a pharmaceutical composition comprising of therapeutically effective amounts of Paeonia lactiflora and Glycyrrhiza uralensis to a subject in need. The pharmaceutical composition reduces productions of reactive oxygen species and inflammatory factors to suppress polyglutamine aggregation.
    Type: Grant
    Filed: January 15, 2016
    Date of Patent: February 26, 2019
    Assignee: NATIONAL TAIWAN NORMAL UNIVERSITY
    Inventors: Guey-Jen Lee-Chen, Chiung-Mei Chen
  • Patent number: 10064838
    Abstract: A method for treating tau-associated disease by administering a pharmaceutical composition comprising a tetrahydropyranol derivative to a subject in need is disclosed. Particularly, a method for treating Alzheimer's disease by administering a pharmaceutical composition comprising a tetrahydropyranol derivative to a subject in need is disclosed. The tetrahydropyranol derivatives have demonstrated their abilities for reducing tau aggregation.
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: September 4, 2018
    Assignee: National Taiwan Normal University
    Inventors: Guey-Jen Lee-Chen, Kwun-Min Chen
  • Publication number: 20180042864
    Abstract: The present invention provides a use of a compound to prepare a pharmaceutical composition for treating abnormal ?-amyloid aggregation mediated diseases. The compound is represented by the following formula (I): wherein A, B, R1, R2, R3, R4, R5 and R6 are defined in the specification.
    Type: Application
    Filed: July 21, 2017
    Publication date: February 15, 2018
    Inventors: Guey-Jen LEE-CHEN, Wenwei LIN
  • Publication number: 20180042889
    Abstract: A method for treating tau-associated disease by administering a pharmaceutical composition comprising a tetrahydropyranol derivative to a subject in need is disclosed. Particularly, a method for treating Alzheimer's disease by administering a pharmaceutical composition comprising a tetrahydropyranol derivative to a subject in need is disclosed. The tetrahydropyranol derivatives have demonstrated their abilities for reducing tau aggregation.
    Type: Application
    Filed: February 16, 2017
    Publication date: February 15, 2018
    Inventors: Guey-Jen LEE-CHEN, Kwun-Min CHEN
  • Patent number: 9795600
    Abstract: A method for treating abnormal ?-amyloid mediated diseases is disclosed, comprising administering a pharmaceutical composition to a subject in need, wherein the pharmaceutical composition comprises an indolylquinoline derivative represented by the following formula 1:
    Type: Grant
    Filed: May 12, 2015
    Date of Patent: October 24, 2017
    Assignee: NATIONAL TAIWAN NORMAL UNIVERSITY
    Inventors: Guey-Jen Lee-Chen, Hsiu-Mei Hsieh, Ching-Fa Yao
  • Patent number: 9770478
    Abstract: The invention relates to a novel use of the Chinese herb Glycyrrhiza inflata in treatment of neurodegenerative disorders. Particularly, the invention relates to the use of ammonium glycyrrhizinate and licochalcone A in targeting polyQ-mediated spinocerebellar ataxia.
    Type: Grant
    Filed: December 30, 2014
    Date of Patent: September 26, 2017
    Assignee: NATIONAL TAIWAN NORMAL UNIVERSITY
    Inventors: Guey-Jen Lee-Chen, Chiung-Mei Chen
  • Publication number: 20170202792
    Abstract: A method for treating a tau-associated disease is disclosed, which comprises the step of administering a pharmaceutical composition to a subject in need. Particularly, a method for treating Alzheimer's disease is disclosed, which comprises the step of administering a pharmaceutical composition to a subject in need.
    Type: Application
    Filed: August 16, 2016
    Publication date: July 20, 2017
    Inventors: Hsiu-Mei HSIEH, Ying-Chieh SUN, Guan-Chiun LEE, Guey-Jen LEE-CHEN, Ming-Tsan SU, Hui-Chen HUANG, Yu-Shao HSIEH, Chia-Jen HSU
  • Patent number: 9629835
    Abstract: A method for treating tau-associated disease by administering a pharmaceutical composition comprising a quinoline derivative to a subject in need is disclosed. Particularly, a method for treating Alzheimer's disease by administering a pharmaceutical composition comprising a quinoline derivative to a subject in need is disclosed. The two disclosed quinoline derivatives have the inhibition effect for GSK-3? kinase activity, so as the two disclosed quinoline derivatives have the ability for inhibiting tau hyperphosphorylation or reducing tau aggregation.
    Type: Grant
    Filed: August 16, 2016
    Date of Patent: April 25, 2017
    Assignee: National Taiwan Normal University
    Inventors: Guey-Jen Lee-Chen, Hsiu-Mei Hsieh, Guan-Chiun Lee, Ying-Chieh Sun
  • Publication number: 20170000835
    Abstract: The present invention relates to a method for treating spinocerebellar ataxias comprising administering a pharmaceutical composition comprising of therapeutically effective amounts of Paeonia lactiflora and Glycyrrhiza uralensis to a subject in need. The pharmaceutical composition reduces productions of reactive oxygen species and inflammatory factors to suppress polyglutamine aggregation.
    Type: Application
    Filed: January 15, 2016
    Publication date: January 5, 2017
    Inventors: Guey-Jen LEE-CHEN, Chiung-Mei CHEN
  • Patent number: 9463197
    Abstract: A method for treating an abnormal polyglutamine-mediated disease is disclosed, which comprises: administering a pharmaceutical composition comprising a trehalose-based compound to a subject in need. Additionally, the pharmaceutical composition optionally further comprises a trehalase inhibitor.
    Type: Grant
    Filed: July 15, 2014
    Date of Patent: October 11, 2016
    Assignee: NATIONAL TAIWAN NORMAL UNIVERSITY
    Inventors: Guey-Jen Lee-Chen, Hsiu-Mei Hsieh, Guan-Chiun Lee
  • Patent number: 9393229
    Abstract: A method for treating an abnormal polyglutamine-mediated disease is disclosed, wherein indole and an indole-based compound contained in a pharmaceutical composition used in the method of the present invention can reduce the polyglutamine aggregation through decreasing reactive oxygen species production and increasing the activity of chaperone and autophagy.
    Type: Grant
    Filed: May 20, 2014
    Date of Patent: July 19, 2016
    Assignee: NATIONAL TAIWAN NORMAL UNIVERSITY
    Inventors: Guey-Jen Lee-Chen, Hsiu-Mei Hsieh, Ching-Fa Yao
  • Publication number: 20160143899
    Abstract: A method for treating abnormal ?-amyloid mediated diseases is disclosed, comprising administering a pharmaceutical composition to a subject in need, wherein the pharmaceutical composition comprises an indolylquinoline derivative represented by the following formula 1:
    Type: Application
    Filed: May 12, 2015
    Publication date: May 26, 2016
    Inventors: Guey-Jen LEE-CHEN, Hsiu-Mei HSIEH, Ching-Fa YAO
  • Publication number: 20150190444
    Abstract: The invention relates to a novel use of the Chinese herb Glycyrrhiza inflata in treatment of neurodegenerative disorders. Particularly, the invention relates to the use of ammonium glycyrrhizinate and licochalcone A in targeting polyQ-mediated spinocerebellar ataxia.
    Type: Application
    Filed: December 30, 2014
    Publication date: July 9, 2015
    Inventors: Guey-Jen LEE-CHEN, Chiung-Mei CHEN
  • Publication number: 20150064287
    Abstract: The present invention relates to a method for treating abnormal polyglutamine-mediated diseases comprising: administering a pharmaceutical composition comprising one or more selected from the group consisting of a Gardenia jasminoides extract, geniposide and crocin.
    Type: Application
    Filed: August 19, 2014
    Publication date: March 5, 2015
    Inventors: Guey-Jen LEE-CHEN, Chiung Mei CHEN
  • Publication number: 20150025028
    Abstract: A method for treating an abnormal polyglutamine-mediated disease is disclosed, which comprises: administering a pharmaceutical composition comprising a trehalose-based compound to a subject in need. Additionally, the pharmaceutical composition optionally further comprises a trehalase inhibitor.
    Type: Application
    Filed: July 15, 2014
    Publication date: January 22, 2015
    Inventors: Guey-Jen LEE-CHEN, Hsiu-Mei HSIEH, Guan-Chiun LEE
  • Publication number: 20140357689
    Abstract: A method for treating an abnormal polyglutamine-mediated disease is disclosed, wherein indole and an indole-based compound contained in a pharmaceutical composition used in the method of the present invention can reduce the polyglutamine aggregation through decreasing reactive oxygen species production and increasing the activity of chaperone and autophagy.
    Type: Application
    Filed: May 20, 2014
    Publication date: December 4, 2014
    Applicant: National Taiwan Normal University
    Inventors: Guey-Jen LEE-CHEN, Hsiu-Mei HSIEH, Ching-Fa YAO
  • Publication number: 20140249095
    Abstract: A method for inhibiting spinocerebellar ataxia is disclosed, which comprises: administering an extract of Paeonia lactiflora to a subject in need; wherein a concentration of the extract of Paeonia lactiflora is in the range from 1 ?g/mL to 80 ?g/mL.
    Type: Application
    Filed: February 28, 2014
    Publication date: September 4, 2014
    Applicant: National Normal University
    Inventors: Guey-Jen LEE-CHEN, Chiung-Mei CHEN
  • Publication number: 20140065669
    Abstract: A neuroblastoma host cell line for stably expressing human exogenous protein is provided. The cell line is generated by independently integrating control plasmid and switch plasmid into genome of human neuroblastoma SH-SY5Y cells. Upon inserting diseased gene into the above cell line, the cell line thus stably expresses the interested protein by induction, which can be used to study human neurological diseases related to the gene mutation.
    Type: Application
    Filed: April 8, 2013
    Publication date: March 6, 2014
    Applicant: National Taiwan Normal University
    Inventors: Guey-Jen LEE-CHEN, Li-Ching LEE, Chih-Hsin LIN
  • Publication number: 20130345074
    Abstract: A biomarker and a method for evaluating a risk for Parkinson's disease are disclosed. The method comprises: obtaining a sample from a tester, analyzing the polymorphic biomarker of the sample, wherein the biomarker is substrate-specifying subunit of SCF E3 ubiquitin ligase complex-FBXO7 gene; and when the cDNA sequence in position 155 of the biomarker is G or the amino acid sequence in position 52 of the biomarker is cysteine, it represents that the tester has a lower risk for Parkinson's disease.
    Type: Application
    Filed: March 14, 2013
    Publication date: December 26, 2013
    Inventors: Guey-Jen LEE-CHEN, Chiung-Mei CHEN, Yih-Ru WU