Abstract: An implantable xenograft intended for human recipients for correcting cardiovascular abnormalities. The xenografts are prepared from a non-human native tissue portion and are completely sterilized, acellular and exhibit a tensile strength generally higher than that of the native tissue. The uniqueness of the xenografts is that the outer surface of the tissue portion is impregnated with collagen nano-fibers. The implantable xenograft exhibits excellent storage stability, non-immunogenicity, non-thrombogenicity, non-cytotoxicity and non-calcifying properties.