Patents by Inventor Guhuan Liu

Guhuan Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Conjugate and block copolymer containing fluorescent chromophore and preparation method therefor and use thereof
    Patent number: 11129909
    Abstract: A conjugate containing a fluorescent chromophore, which has any structure selected from C1 to C3. The conjugate containing the fluorescent chromophore provided by the described embodiments includes one fluorescent chromophore and two highly reactive groups R1 and R2 linked to the fluorescent chromophore by a covalent bond. The fluorescent chromophore in the conjugate initially has no or only weak fluorescence emission capability, and only after the two highly reactive groups react together with the corresponding molecule, the fluorescent chromophore has strong fluorescence emission. Therefore, the efficiency of conjugation of drug molecules to targeting molecules can be monitored in situ by the infrared fluorescence emission intensity and applied to the target-mediated drug delivery.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: September 28, 2021
    Assignee: University of Science and Technology of China
    Inventors: Shiyong Liu, Guhuan Liu, Yanyan Jiang
  • CONJUGATE AND BLOCK COPOLYMER CONTAINING FLUORESCENT CHROMOPHORE AND PREPARATION METHOD THEREFOR AND USE THEREOF
    Publication number: 20200155707
    Abstract: A conjugate containing a fluorescent chromophore, which has any structure selected from C1 to C3. The conjugate containing the fluorescent chromophore provided by the described embodiments includes one fluorescent chromophore and two highly reactive groups R1 and R2 linked to the fluorescent chromophore by a covalent bond. The fluorescent chromophore in the conjugate initially has no or only weak fluorescence emission capability, and only after the two highly reactive groups react together with the corresponding molecule, the fluorescent chromophore has strong fluorescence emission. Therefore, the efficiency of conjugation of drug molecules to targeting molecules can be monitored in situ by the infrared fluorescence emission intensity and applied to the target-mediated drug delivery.
    Type: Application
    Filed: May 16, 2017
    Publication date: May 21, 2020
    Applicant: University of Science and Technology of China
    Inventors: Shiyong Liu, Guhuan Liu, Yanyan Jiang