Patents by Inventor Gui-Chao Kuang

Gui-Chao Kuang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Unsymmetrical bisazides for chemoselective sequential ligation
    Patent number: 8871940
    Abstract: Unsymmetrical bisazides containing chelating and non-chelating azido groups undergo chemoselective three-component copper(I)-catalyzed azide-alkyne conjugation reactions with two different alkyne molecules. In conjunction with the reactivity gap between aromatic and aliphatic alkynes, a bistriazole molecule can be generated with an excellent regioselectivity by mixing two alkynes and a bisazide in a single reaction container. This method is applicable in aqueous solutions at neutral pH, which may lend utilities in bioconjugation applications.
    Type: Grant
    Filed: July 15, 2013
    Date of Patent: October 28, 2014
    Assignee: The Florida State University Research Foundation, Inc.
    Inventors: Lei Zhu, Zhao Yuan, Gui-Chao Kuang
  • UMSYMMETRICAL BISAZIDES FOR CHEMOSELECTIVE SEQUENTIAL LIGATION
    Publication number: 20140018541
    Abstract: Unsymmetrical bisazides containing chelating and non-chelating azido groups undergo chemoselective three-component copper(I)-catalyzed azide-alkyne conjugation reactions with two different alkyne molecules. In conjunction with the reactivity gap between aromatic and aliphatic alkynes, a bistriazole molecule can be generated with an excellent regioselectivity by mixing two alkynes and a bisazide in a single reaction container. This method is applicable in aqueous solutions at neutral pH, which may lend utilities in bioconjugation applications.
    Type: Application
    Filed: July 15, 2013
    Publication date: January 16, 2014
    Applicant: The Florida State University Research Foundation, Inc.
    Inventors: Lei Zhu, Zhao Yuan, Gui-Chao Kuang