Patents by Inventor Gui Gao

Gui Gao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bax fragment induced tumor cell death
    Publication number: 20030004111
    Abstract: The present invention relates treatment of tumors using a Bax protein fragment to induce apoptosis. More specifically, the present invention relates to the use of the Bax amino terminus 18 kDa fragment to induce cytochrome c release and apoptosis in cancer cells. Further provided is the method of inducing cell death even in cancer cells overexpressing Bcl-2 oncoprotein. Further provided is a method using Bax/p18 of triggering cytochrome c release, activation of caspase-3, cleavage of poly(ADP-ribose) polymerase, fragmentation of DNA and induction of cell death.
    Type: Application
    Filed: September 4, 2002
    Publication date: January 2, 2003
    Inventors: Ping Dou, Gui Gao
  • Bax fragment induced tumor cell death
    Publication number: 20020022594
    Abstract: The present invention relates treatment of tumors using a Bax protein fragment to induce apoptosis. More specifically, the present invention relates to the use of the Bax amino terminus 18 kDa fragment to induce cytochrome c release and apoptosis in cancer cells. Further provided is the method of inducing cell death even in cancer cells overexpressing Bcl-2 oncoprotein. Further provided is a method using Bax/p18 of triggering cytochrome c release, activation of caspase-3, cleavage of poly(ADP-ribose) polymerase, fragmentation of DNA and induction of cell death. Further provided is a method of introducing Bax/p18 protein into a cancer cell via introducing Bax/p18 cDNA, to cause release of cytochrome c and induction of caspase-3 mediated apoptosis that is not blocked by overexpression of Bcl-2.
    Type: Application
    Filed: July 11, 2001
    Publication date: February 21, 2002
    Inventors: Ping Dou, Gui Gao