Abstract: The invention provides novel compositions and linking configurations for an oligonucleotide to be conjugated to a ligand for targeted in vivo delivery of an oligonucleotide. The invention further provides use of the resulting compounds and pharmaceutical compositions thereof in preparation of a medicament effective for treating a disease or condition.

Abstract: A motor controller includes a housing, a power circuit board, and a control circuit board. The housing includes a first mounting platform, a second mounting platform, and a side wall. There is a height difference between the first mounting platform and the second mounting platform. The first mounting platform is disposed on an upper part of the side wall, and the second mounting platform is disposed on a middle part of the side wall. The second mounting platform is disposed on one side of the first mounting platform. The first mounting platform and the side wall form an upper chamber, and the control circuit board and the power circuit board are disposed in the upper chamber. The control circuit board is closer to the first mounting platform than the power circuit board. The second mounting platform and the side wall form a lower chamber communicating with the upper chamber.

Abstract: Photography equipment, specifically a clamping and supporting apparatus for a smart mobile terminal, including an accommodating member and a mobile phone clamp assembly. The accommodating member includes an accommodating body and a connecting plate rotatably connected to the accommodating body. The mobile phone clamp assembly is disposed on the connecting plate and configured to be received in the accommodating body. The connecting plate rotates to allow the mobile phone clamp assembly to be received in the accommodating body. When the mobile phone clamp assembly is not in use, the connecting plate is rotated to allow the mobile phone clamp assembly to be received, so that space is saved and the accommodation and placement of the clamping and supporting apparatus are facilitated. The accommodating body is a handle, so that one can conveniently hold the accommodating body with one hand and open or close the connecting plate with the other hand.

Abstract: A standardized artificial intelligence automatic radiotherapy planning method includes acquiring a medical image; automatically delineating an ROI area of the medical image to acquire a geometric anatomical structure; determining a prescription according to disease type information corresponding to the medical image, the geometric anatomical structure, and a preset disease-prescription template library, and determining a radiation angle of radiation therapy; obtaining a radiation therapy dose distribution result using a dose prediction model; performing optimization processing using a reverse optimization algorithm based on dose distribution or DVH guidance, with reference to the radiation dose distribution result, to generate executable radiation therapy plans.

Abstract: A method for simulating a particle transport may include recording transport paths of inputted particles and determining an uncertainty of each of lattice cells based on the transport paths of each batch of the inputted particles, a lattice cell being a qualified lattice cell if an uncertainty of the lattice cell does not exceed a first threshold; determining a standard-reaching rate of lattice cells in a region of interest (ROI), the ROI including at least one lattice cell, the standard-reaching rate of lattice cells in the ROI being equal to a ratio of the number of qualified lattice cells to a total number of lattice cells in the ROI; and if the standard-reaching rate of lattice cells in the ROI exceeds a second threshold, stopping inputting particles, and outputting the transport paths of the inputted particles.

Abstract: The present disclosure provides a system and method for X-ray imaging. The method of calculating scatter in an X-ray image may include forming a modulated X-ray image. The method of forming the modulated X-ray image may include acquiring X-rays through a collimator module and an imaged object in sequence to generate an X-ray image group; the acquisition may be performed during a movement of the collimator module in a first direction and the X-ray image group may include a plurality of X-ray images acquired at different times during the movement of the collimator; extracting sub-zones from the plurality of X-ray images in the X-ray image group; combining the sub-zones in the first direction to form the modulated X-ray image. In the present disclosure, an intensity distribution of the X-rays may be adjusted flexibly using a collimator without adding any extra hardware. In addition, scatter components in the X-ray images may be calculated to eliminate the scatter in the X-ray images finally.

Abstract: A method for simulating a particle transport may include recording transport paths of inputted particles and determining an uncertainty of each of lattice cells based on the transport paths of each batch of the inputted particles, a lattice cell being a qualified lattice cell if an uncertainty of the lattice cell does not exceed a first threshold; determining a standard-reaching rate of lattice cells in a region of interest (ROI), the ROI including at least one lattice cell, the standard-reaching rate of lattice cells in the ROI being equal to a ratio of the number of qualified lattice cells to a total number of lattice cells in the ROI; and if the standard-reaching rate of lattice cells in the ROI exceeds a second threshold, stopping inputting particles, and outputting the transport paths of the inputted particles.

Abstract: The present disclosure discloses a standardized artificial intelligence automatic radiotherapy planning method and system, wherein the radiation therapy planning method includes: acquiring a medical image; automatically delineating an ROI area of the medical image to acquire a geometric anatomical structure; determining a prescription according to disease type information corresponding to the medical image, the geometric anatomical structure, and a preset disease-prescription template library, and determining a radiation angle of radiation therapy; obtaining a radiation therapy dose distribution result using a dose prediction model; performing optimization processing using a reverse optimization algorithm based on dose distribution or DVH guidance, with reference to the radiation dose distribution result, to generate executable radiation therapy plans.

Abstract: Photography equipment, specifically a clamping and supporting apparatus for a smart mobile terminal, including an accommodating member and a mobile phone clamp assembly. The accommodating member includes an accommodating body and a connecting plate rotatably connected to the accommodating body. The mobile phone clamp assembly is disposed on the connecting plate and configured to be received in the accommodating body. The connecting plate rotates to allow the mobile phone clamp assembly to be received in the accommodating body. When the mobile phone clamp assembly is not in use, the connecting plate is rotated to allow the mobile phone clamp assembly to be received, so that space is saved and the accommodation and placement of the clamping and supporting apparatus are facilitated. The accommodating body is a handle, so that one can conveniently hold the accommodating body with one hand and open or close the connecting plate with the other hand.

Abstract: There is provided an assembleable aquaboard made of fiber-reinforced plastic (FRP), including: a first plate having a first T-shaped slot on the top surface and a second T-shaped slot on the right side surface, a second plate having a third T-shaped slot on the top surface and a fourth T-shaped slot on the right side surface; a third plate having a fifth T-shaped slot on the top surface, a sixth T-shaped slot on the right side surface; a fourth plate having a seventh T-shaped slot on the top surface and an eighth T-shaped slot on the left side surface; a first T-shaped connector to connect the first and the third plates; a second T-shaped to connect the second and the fourth plates; and a first I-beam connector to connect the first plate, the second, the third plate and the fourth plate to form the assembleable aquaboard.

Abstract: The present disclosure provides a system and method for X-ray imaging. The method of calculating scatter in an X-ray image may include forming a modulated X-ray image. The method of forming the modulated X-ray image may include acquiring X-rays through a collimator module and an imaged object in sequence to generate an X-ray image group; the acquisition may be performed during a movement of the collimator module in a first direction and the X-ray image group may include a plurality of X-ray images acquired at different times during the movement of the collimator; extracting sub-zones from the plurality of X-ray images in the X-ray image group; combining the sub-zones in the first direction to form the modulated X-ray image. In the present disclosure, an intensity distribution of the X-rays may be adjusted flexibly using a collimator without adding any extra hardware. In addition, scatter components in the X-ray images may be calculated to eliminate the scatter in the X-ray images finally.

Abstract: The present disclosure provides a system and method for X-ray imaging. The method of calculating scatter in an X-ray image may include forming a modulated X-ray image. The method of forming the modulated X-ray image may include acquiring X-rays through a collimator module and an imaged object in sequence to generate an X-ray image group; the acquisition may be performed during a movement of the collimator module in a first direction and the X-ray image group may include a plurality of X-ray images acquired at different times during the movement of the collimator; extracting sub-zones from the plurality of X-ray images in the X-ray image group; combining the sub-zones in the first direction to form the modulated X-ray image. In the present disclosure, an intensity distribution of the X-rays may be adjusted flexibly using a collimator without adding any extra hardware. In addition, scatter components in the X-ray images may be calculated to eliminate the scatter in the X-ray images finally.

Abstract: A method for simulating a particle transport may include recording transport paths of inputted particles and determining an uncertainty of each of lattice cells based on the transport paths of each batch of the inputted particles, a lattice cell being a qualified lattice cell if an uncertainty of the lattice cell does not exceed a first threshold; determining a standard-reaching rate of lattice cells in a region of interest (ROI), the ROI including at least one lattice cell, the standard-reaching rate of lattice cells in the ROI being equal to a ratio of the number of qualified lattice cells to a total number of lattice cells in the ROI; and if the standard-reaching rate of lattice cells in the ROI exceeds a second threshold, stopping inputting particles, and outputting the transport paths of the inputted particles.

Abstract: A clamping device for an intelligent mobile terminal includes a first clamping member provided with a first clamping portion; and a second clamping member slidably engaged with the first clamping member and provided with a second clamping portion, a space for clamping the intelligent mobile terminal being formed between the second clamping portion and the first clamping portion, wherein an end of the first clamping member away from the second clamping member in a sliding direction is provided with a male connector, and an end of the second clamping member away from the first clamping member in the sliding direction is provided with a female connector that matches the male connector.

Abstract: There is provided an assembleable boat made of fiber-reinforced plastic (FRP) including a bottom wall assembly; a left side wall assembly; a right side wall assembly; and a front wall assembly. the bottom wall assembly, the back wall assembly, the left side wall assembly, the right wall assembly, and the front wall assembly are mechanically connected to form the assembleable boat; and each of the bottom wall assembly, the left side wall assembly, the right wall assembly, and the front wall assembly is made of FRP.

Abstract: A method for simulating a particle transport may include recording transport paths of inputted particles and determining an uncertainty of each of lattice cells based on the transport paths of each batch of the inputted particles, a lattice cell being a qualified lattice cell if an uncertainty of the lattice cell does not exceed a first threshold; determining a standard-reaching rate of lattice cells in a region of interest (ROI), the ROI including at least one lattice cell, the standard-reaching rate of lattice cells in the ROI being equal to a ratio of the number of qualified lattice cells to a total number of lattice cells in the ROI; and if the standard-reaching rate of lattice cells in the ROI exceeds a second threshold, stopping inputting particles, and outputting the transport paths of the inputted particles.

Abstract: The present invention relates to the technical field of cloud computing and relates to a standardized cloud radiotherapy planning method, a storage medium, and a system. The method comprises the following steps: (1) patient data is uploaded to a master cloud server (S210), where the patient data comprises a patient image and medical order data; (2) a target area is delineated on the basis of the patient image (S220); (3) the master cloud server assigns a computation task to a controlled computer, the controlled computer uses a standard radiotherapy equipment mode to compute a radiotherapy plan for a patient, thus generating a standard radiotherapy plan (S230); and, (4) a specific radiotherapy plan matching specific radiotherapy equipment is generated on the basis of the standard radiotherapy plan.

Abstract: There is provided a standard block made of fiber-reinforced plastic (FRP), including a first slot and a second slot parallel to the first slot on the top surface of the standard block; a third slot and a fourth slot parallel to the first slot on the bottom surface of the standard block; a fifth slot parallel to the first slot on the right side surface of the standard block; and a sixth slot parallel to the first slot on the left side surface of the standard block.

Abstract: There is provided an assembleable boat made of fiber-reinforced plastic (FRP) including a bottom wall assembly; a left side wall assembly; a right side wall assembly; and a front wall assembly. the bottom wall assembly, the back wall assembly, the left side wall assembly, the right wall assembly, and the front wall assembly are mechanically connected to form the assembleable boat; and each of the bottom wall assembly, the left side wall assembly, the right wall assembly, and the front wall assembly is made of FRP.

Abstract: There is provided an assembleable aquaboard made of fiber-reinforced plastic (FRP), including: a first plate having a first T-shaped slot on the top surface and a second T-shaped slot on the right side surface, a second plate having a third T-shaped slot on the top surface and a fourth T-shaped slot on the right side surface; a third plate having a fifth T-shaped slot on the top surface, a sixth T-shaped slot on the right side surface; a fourth plate having a seventh T-shaped slot on the top surface and an eighth T-shaped slot on the left side surface; a first T-shaped connector to connect the first and the third plates; a second T-shaped to connect the second and the fourth plates; and a first I-beam connector to connect the first plate, the second, the third plate and the fourth plate to form the assembleable aquaboard.