Abstract: The present invention relates to a novel and improved process for preparing (5S)-{[2-(4-carboxyphenyl)ethyl][2-(2-{[3-chloro-4?-(trifluo-romethyl)biphenyl-4-yl]methoxy}phenyl)ethyl]amino}-5,6,7,8-tetrahydroquinoline-2-carboxylic acid of the formula (I) and to novel crystalline forms of it, which is i.a. the pseudopolymorphic form monohydrate I (I-M-I) or the pseudopolymorphic form monohydrate II (I-M-II), furthermore the present invention relates to a novel and selective crystallization process for preparation of the pseudopolymorphic form monohydrate I (I-M-I) or the pseudopolymorphic form monohydrate II (I-M-II), preferably monohydrate I of formula (I-M-I) and to pharmaceutical compositions comprising monohydrate I of formula (I-M-I) and to its use for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of pulmonary and cardiopulmonary and cardiovascular diseases.

Abstract: The present application relates to a novel and efficient process with high yield for preparing methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate of the formula (I) in the crystalline form of modification I, wherein the x-ray diffractogram of the compound of the formula (I) in modification exhibits peak maxima of the 2 theta angle at 5.9, 6.9, 22.7, in very high purity which is significantly more cost-effective than the process known from the art and can be performed in customary pilot- and production plant-equipment (stirred tank/devices for isolation).

Abstract: The present invention relates to stable nanosuspensions of methyl {4,6-diamino-2-[5-fluoro-1-(2- fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate (Vericiguat, compound of formula (I)), processes for preparing the stable nanosuspensions, nanoparticles comprising the compound of formula (I), and pharmaceutical compositions in solid form made from the nanosuspensions.

Abstract: The present invention relates to methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate in the form of a novel active compound product having improved properties, for example in respect of the isolability of the active compound product, the dischargeability of the active compound product after isolation and drying and also conveyability, sieveability and micronizability of the active compound product, and to processes for the production and formulation thereof.

Abstract: The invention relates to a method for producing aminobenzoic acid or a aminobenzoic acid derivative via the fermentation of a suitable raw material under the influence of suitable microorganisms and obtaining a fermentation broth containing aminobenzoate and/or aminobenzoic acid. In particular, the invention relates to the step of obtaining the aminobenzoic acid from the fermentation broth, wherein the crystallisation of aminobenzoic acid is carried out via a simple one-stage acid treatment in the presence of seed crystals. The aminobenzoic acid crystallised in this simple manner can be easily separated from the mother liquor, further cleaned if necessary, and then supplied to the different applications.

Abstract: The invention relates to a method for combating salmon lice and other ectoparasites in aquaculture, in which fish are breed in breeding nets, breeding containers or breeding basins inshore or offshore and are fattened. When changing from one breeding net to another breeding net, the fish swim through a channel or a pipe (3) and are subjected to UV-light treatment (4) or to pulsed ultrasonication (5) or a UV light treatment and pulsed ultrasonication, or the fish are removed for a brief period from the breeding nets or breeding containers or breeding basins and are subjected to UV treatment or infra-red treatment (13) and/or are exposed to microwave irradiation (14) outside of the water.

Abstract: The invention relates to a method for producing aminobenzoic acid or a aminobenzoic acid derivative via the fermentation of a suitable raw material under the influence of suitable microorganisms and obtaining a fermentation broth containing aminobenzoate and/or aminobenzoic acid. In particular, the invention relates to the step of obtaining the aminobenzoic acid from the fermentation broth, wherein the crystallisation of aminobenzoic acid is carried out via a simple one-stage acid treatment in the presence of seed crystals. The aminobenzoic acid crystallised in this simple manner can be easily separated from the mother liquor, further cleaned if necessary, and then supplied to the different applications.

Abstract: The invention relates to a seat-belt warning device comprising a device which detects a seat occupied by a passenger, a device which detects whether the seat-belt associated with a seat is being used, and a device which emits a warning signal. According to the invention, the device which detects seat occupancy by a passenger comprises an optical image-producing system comprising an image evaluation unit.

Abstract: The present application relates to a novel and improved process for preparing the compound 2-{4-[2-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulphanyl)-3,5-dicyano-6-(pyrrolidin-1-yl)pyridin-4-yl]phenoxy}ethyl-L-alanyl L-alaninate monohydrochloride of the formula (I) to novel precursors for its preparation, and to the preparation and use of crystal modification I of 2-{4-[2-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulphanyl)-3,5-dicyano-6-(pyrrolidin-1-yl)pyridin-4-yl]phenoxy}-ethyl-L-alanyl L-alaninate monohydrochloride of the formula (I).

Abstract: An apparatus in a motor vehicle for spatial detection of a scene inside and/or outside the motor vehicle has a LIDAR sensor, which is coupled to an electronic detection device, and an image sensor, which is connected to an image processing device for recording and evaluation of images of the scene. The detection device and the image processing device are coupled to a computer in order to determine spatial data of the scene.

Abstract: The invention relates to formulations of hygroscopic solids with a lipophilic coating layer, and a method of production thereof.

Abstract: The invention relates to a device for detecting and localising objects. The inventive device comprises a 3D camera for recording three-dimensional situation images of an area to be monitored; first means for evaluating the three-dimensional situation images using suitable object detection methods for determining an object in the area to be monitored and the position of the object in said area; a 2D camera for recording two-dimensional situation images of the region in the area to be monitored in which the position of the object has been determined; and second means for evaluating the two-dimensional situation images using suitable object detection methods for redetermining the object in the area to be monitored.

Abstract: The method serves for canceling errors caused by mismatch of different signal paths in a photodetector with a plurality (k) of storage elements for the photogenerated signals, as typically used in phase-measurement systems. The signal-capturing process is performed in at least two measurement cycles (j) . A first cycle (j=1) is executed with the conventional setup with no phase delay in the control signals. It is followed by further measurement cycles (j=2, 3, 4) which use control signals shifted by a constant phase shift (90°). Corresponding signals are read out through different signal paths. At the end, the signals corresponding to a certain phase (?) are added, thus canceling possible offset values.

Abstract: The invention relates to a seat-belt warning device comprising a device which detects a seat occupied by a passenger, a device which detects whether the seat-belt associated with a seat is being used, and a device which emits a warning signal. According to the invention, the device which detects seat occupancy by a passenger comprises an optical image-producing system comprising an image evaluation unit.

Abstract: The method serves for canceling errors caused by mismatch of different signal paths in a photodetector with a plurality (k) of storage elements for the photogenerated signals, as typically used in phase-measurement systems. The signal-capturing process is performed in at least two measurement cycles (j) . A first cycle (j=1) is executed with the conventional setup with no phase delay in the control signals. It is followed by further measurement cycles (j=2, 3, 4) which use control signals shifted by a constant phase shift (90°). Corresponding signals are read out through different signal paths. At the end, the signals corresponding to a certain phase (?) are added, thus canceling possible offset values.

Abstract: A method for providing parking aid for a vehicle, comprises the steps recording ambient data in the external area of a vehicle, calculation of the dimensions of a specific area using the recorded ambient data, and evaluation of the suitability of the specific area as a parking space taking into account the calculated dimensions and known, vehicle-specific reference values. According to the invention, the recording of ambient data comprises recording three-dimensional images of the surroundings by means of an optical 3-D system.

Abstract: An apparatus in a motor vehicle for spatial detection of a scene inside and/or outside the motor vehicle has a LIDAR sensor, which is coupled to an electronic detection device, and an image sensor, which is connected to an image processing device for recording and evaluation of images of the scene. The detection device and the image processing device are coupled to a computer in order to determine spatial data of the scene.

Abstract: The invention relates to a device for detecting and localising objects. The inventive device comprises a 3D camera for recording three-dimensional situation images of an area to be monitored; first means for evaluating the three-dimensional situation images using suitable object detection methods for determining an object in the area to be monitored and the position of the object in said area; a 2D camera for recording two-dimensional situation images of the region in the area to be monitored in which the position of the object has been determined; and second means for evaluating the two-dimensional situation images using suitable object detection methods for redetermining the object in the area to be monitored.

Abstract: A method for controlling appliances, machines and/or vehicles comprises the steps of

Abstract: A roller furnace for heating windows to their softening temperature. The furnace is provided above a roller transportation track. Vanes forming blowing nozzles are arranged transversely to the direction of movement of the windows in order to blow hot gas onto the top surface of the window. A radiative heater is provided below the roller transportation track to heat the bottom of the window.