Patents by Inventor Guido Francois

Guido Francois has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antimalarial naphthylisoquinoline alkaloids and pharmaceutical compositions and medical uses thereof
    Patent number: 6627641
    Abstract: The present invention provides antimalarial pharmaceutical compositions containing antimalarial naphthylisoquinoline alkaloids or antimalarial derivatives thereof, useful new antimalarial naphthylisoquinoline alkaloid derivatives, methods for obtaining such derivatives, and methods of using such antimalarial compounds for the prevention of malaria infections in mammals and for treating mammals with malarial infections. The antimalarial compounds of the present invention inhibit the reproduction and cytopathicity of Plasmodium sp. parasites in vitro and in vivo.
    Type: Grant
    Filed: April 16, 1997
    Date of Patent: September 30, 2003
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Guido François, Gerhard Bringmann, J. David Phillipson, Michael R. Boyd, Laurent Aké Assi, Christoph Schneider, Georges Timperman
  • Antimalarial naphthylisoquinoline alkaloids and pharmaceutical compositions and medical uses thereof
    Patent number: 5639761
    Abstract: The present invention provides antimalarial pharmaceutical compositions containing antimalarial naphthylisoquinoline alkaloids or antimalarial derivatives thereof, useful new antimalarial naphthylisoquinoline alkaloid derivatives, methods for obtaining such derivatives, and methods of using such antimalarial compounds for the prevention of malaria infections in mammals and for treating mammals with malarial infections. The antimalarial compounds of the present invention inhibit the reproduction and cytopathicity of Plasmodium sp. parasites in vitro and in vivo.
    Type: Grant
    Filed: February 14, 1994
    Date of Patent: June 17, 1997
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Guido Francois, Gerhard Bringmann, J. David Phillipson, Michael R. Boyd, Laurent Ake Assi, Christoph Schneider, Georges Timperman
  • Antimalarial korupensamines and pharmaceutical compositions and medical uses thereof
    Patent number: 5409938
    Abstract: The present invention provides new antimalarial compounds called korupensamines, korupensamine derivatives, and pharmacologically acceptable salts thereof, methods for isolating such antimalarial korupensamines from the plant Ancistrocladus korupensis, methods for obtaining new korupensamine derivatives, antimalarial compositions containing such antimalarial korupensamines or derivatives thereof or pharmacologically acceptable salts thereof, and methods of using such antimalarial compounds for the prevention of malaria infections or for treating mammals with malarial infections. The antimalarial compounds of the present invention inhibit the reproduction and cytopathicity of Plasmodium sp. parasites in vitro and in vivo.
    Type: Grant
    Filed: February 14, 1994
    Date of Patent: April 25, 1995
    Assignee: The United States of America as represented by the Secretary, Department of Health and Human Services
    Inventors: Michael R. Boyd, Guido Francois, Gerhard Bringmann, Yaii F. Hallock, Kirk P. Manfredi, John H. Cardellina, II