Patents by Inventor Guido Zanetti

Guido Zanetti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2,4-diamino-5[4-amino (or dimethylamino)-3,5-dimethoxybenzyl]pyrimidine and antibacterial composition thereof
    Patent number: 4792557
    Abstract: 2,4-Diamino-5-benzylpyrimidines of the formula ##STR1## wherein R.sup.1, R.sup.2, A, Z and n are as hereinafter set forth, are described. The 2,4-diamino-5-benzylpyrimidines of the invention have useful antibacterial activity. More particularly, they inhibit bacterial dihydrofolate reductase and potentiate the antibacterial activity of sulfonamides.
    Type: Grant
    Filed: January 14, 1987
    Date of Patent: December 20, 1988
    Assignee: Hoffman-La Roche Inc.
    Inventors: Ivan Kompis, G/e/ rald Rey-Bellet, Guido Zanetti
  • Intermediates for benzylpyrimidines
    Patent number: 4659818
    Abstract: 2,4-Diamino-5-benzylpyrimidines of the formula ##STR1## wherein R.sup.1, R.sup.2, A, Z and n are as hereinafter set forth, are described. The 2,4-diamino-5-benzylpyrimidines of the invention have useful antibacterial activity. More particularly, they inhibit bacterial dihydrofolate reductase and potentiate the antibacterial activity of sulfonamides.
    Type: Grant
    Filed: February 27, 1985
    Date of Patent: April 21, 1987
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Ivan Kompis, Gerald Rey-Bellet, Guido Zanetti
  • 2,4-Diamino-5-(4-amino and 4-dimethylamino-3,5-dimethoxy benzyl)pyrimidines
    Patent number: 4515948
    Abstract: 2,4-Diamino-5-benzylpyrimidines of the formula ##STR1## wherein R.sup.1, R.sup.2, A, Z and n are as hereinafter set forth, are described. The 2,4-diamino-5-benzylpyrimidines of the invention have useful antibacterial activity. More particularly, they inhibit bacterial dihydrofolate reductase and potentiate the antibacterial activity of sulfonamides.
    Type: Grant
    Filed: June 30, 1981
    Date of Patent: May 7, 1985
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Ivan Kompis, Gerald Rey-Bellet, Guido Zanetti
  • Benzylpyrimidines
    Patent number: 4251454
    Abstract: Benzylpyrimidines of the formula ##STR1##wherein R.sup.1, R.sup.2, A, Z and n are as hereinafter described, are prepared. The benzylpyrimidines are useful as potentiators of the activity of the sulfonamides.
    Type: Grant
    Filed: July 24, 1978
    Date of Patent: February 17, 1981
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Ivan Kompis, Gerald Rey-Bellet, Guido Zanetti
  • Benzylpyrimidines
    Patent number: 4039543
    Abstract: Benzylpyrimidines of the formula ##STR1## wherein R.sup.1 and R.sup.2 each, independently, is amino, optionally C.sub.1.sub.-3 -alkyl-substituted pyrrolo, pyrrolidino, piperidino, -NHR.sup.3, -N(R.sup.3).sub.2, -NHR.sup.4, -N(R.sup.3)(R.sup.4),-NR.sup.3 COOR.sup.3, -NHCOOR.sup.3, -NHCONHR.sup.3, -NHCONH.sub.2 or -N(NO)R.sup.3 or wherein R.sup.3 is C.sub.1.sub.-4 -alkyl or C.sub.2.sub.-4 -alkenyl, R.sup.4 is acyl; Z is hydrogen, chlorine, bromine, pyrrolo, pyrrolidino, piperidino or morpholino or R.sup.3, OR.sup.3 or -N(R.sup.3).sub.2 ; A is an oxygen atom bonded to one of the cyclic nitrogen atoms; and n is 0 or 1 are prepared. The benzylpyrimidines are useful as potentiators of the activity of the sulfonamides.
    Type: Grant
    Filed: December 19, 1975
    Date of Patent: August 2, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Ivan Kompis, Gerald Rey-Bellet, Guido Zanetti
  • 1-Polyhydroxy alkyl-1,4-benzodiazepin-2-ones
    Patent number: 3963777
    Abstract: Novel 1,4-benzodiazepin-2-ones bearing a polyhydroxyalkyl group in the 1-position are disclosed. These 1-substituted benzodiazepins are useful as muscle relaxant, anti-convulsant and sedative agents.
    Type: Grant
    Filed: October 20, 1975
    Date of Patent: June 15, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Joseph Hellerbach, Henri Hoffmann, Guido Zanetti
  • 2,4-Diamino-5-benzylpyrimidines
    Patent number: 3931181
    Abstract: 2,4-Diamino-5-benzylpyrimidines characterized by the formula ##SPC1##Wherein R.sup.1, R.sup.2, A.sup.1, Z and n are as hereinafter set forth, are described. The 2,4-diamino-5-benzylpyrimidines of the invention have useful antibacterial activity. More particularly, they block bacterial dihydrofolate reductase and potentiate the antibacterial activity of sulfonamides.
    Type: Grant
    Filed: July 16, 1974
    Date of Patent: January 6, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Ivan Kompis, Gerald Rey-Bellet, Guido Zanetti