Patents by Inventor Guifang ZHAO

Guifang ZHAO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-pain compound and preparation method thereof
    Patent number: 11795174
    Abstract: Disclosed are a compound represented by the general Formula (I), or a stereisomer, tautomer, derivative, prodrug or pharmaceutically acceptable salt thereof, and a method for preparing the compound and use of the compound in manufacture of a medicament for treating a neuropathic pain and/or neuropathic pain syndrome or a medicament for combating an inflammation: wherein R1 is selected from hydrogen, halogen, alkyl, cyano and haloalkyl, R2 and R3 are independently selected from hydrogen, halogen, alkyl, haloalkyl and nitro, and R1, R2 and R3 are not hydrogen at the same time; furthermore, when either R2 or R3 is nitro or halogen, the other two of R1, R2 and R3 are not hydrogen at the same time. The compound has good effects in treating a neuropathic pain and/or neuropathic pain syndrome and good effects in combating an inflammation, and has not side effects such as addiction.
    Type: Grant
    Filed: December 7, 2018
    Date of Patent: October 24, 2023
    Assignee: LUNAN PHARMACEUTICAL GROUP CORPORATION
    Inventors: Runtao Li, Jia Ye, Xin Wang, Zemei Ge, Yingying Liang, Xiaolei Du, Ding Wang, Guimin Zhang, Jingchun Yao, Guifang Zhao
  • MAGL INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF
    Publication number: 20230090255
    Abstract: The present invention belongs to the field of medicine, and relates to a compound of Formula I and a pharmaceutically acceptable salt thereof for using as a MAGL inhibitor, as well as a preparation method and use thereof, and an intermediate for preparing the same.
    Type: Application
    Filed: July 27, 2020
    Publication date: March 23, 2023
    Inventors: Guimin Zhang, Jinxin Wang, Jingchun Yao, Guifang Zhao
  • OLEAN-PHENYLACRYLAMIDE DERIVATIVE, METHOD FOR PREPARING SAME, AND USE THEREOF
    Publication number: 20230023332
    Abstract: The present invention relates to the fields of medicinal chemistry and pharmacotherapeutics, and in particular to a 2-cyano-3,12-dioxoolean-1,9(11)-dien-17-phenylacrylamide derivative and a preparation method thereof; and the present invention further relates to use of the novel compound in the preparation of an anticancer medicament.
    Type: Application
    Filed: November 26, 2020
    Publication date: January 26, 2023
    Inventors: Guimin ZHANG, Hongbao LIANG, Li CHEN, Guifang ZHAO, Zihao ZHAO, Xiaoyan LU, Chenghong SUN
  • ANTI-PAIN COMPOUND AND PREPARATION METHOD THEREOF
    Publication number: 20200369674
    Abstract: Disclosed are a compound represented by the general Formula (I), or a stereisomer, tautomer, derivative, prodrug or pharmaceutically acceptable salt thereof, and a method for preparing the compound and use of the compound in manufacture of a medicament for treating a neuropathic pain and/or neuropathic pain syndrome or a medicament for combating an inflammation: wherein R1 is selected from hydrogen, halogen, alkyl, cyano and haloalkyl, R2 and R3 are independently selected from hydrogen, halogen, alkyl, haloalkyl and nitro, and R1, R2 and R3 are not hydrogen at the same time; furthermore, when either R2 or R3 is nitro or halogen, the other two of R1, R2 and R3 are not hydrogen at the same time. The compound has good effects in treating a neuropathic pain and/or neuropathic pain syndrome and good effects in combating an inflammation, and has not side effects such as addiction.
    Type: Application
    Filed: December 7, 2018
    Publication date: November 26, 2020
    Applicant: LUNAN PHARMACEUTICAL GROUP CORPORATION
    Inventors: Runtao LI, Jia YE, Xin WANG, Zemei GE, Yingying LIANG, Xiaolei DU, Ding WANG, Guimin ZHANG, Jingchun YAO, Guifang ZHAO