Abstract: A similar simulation experimental device of hydraulic energy-absorbing roadway support is provided. A similar model is placed in a model box, a roadway is excavated in the similar model, and hydraulic energy-absorbing support devices are placed in the roadway on the periphery of the roadway. Front and rear ends of the hydraulic energy-absorbing support device are connected to supporting plates, left and right sides of the model box are provided with horizontal hydraulic cylinders, and front ends of the horizontal hydraulic cylinders are connected to pressure plates. One or several cushion blocks are placed at the top of the model box, and an upper pressure plate is placed above the cushion block(s). Vertical hydraulic cylinders are installed at both ends of the upper pressure plate. An impact rod passing through the upper pressure plate is placed above the cushion block to apply vertical impact load to the similar model.

Abstract: The invention relates a kind of antiviral agents, more concretely, relates to a kind of heterocyclic non-nucleoside compounds with the following structures, their preparation and pharmaceutical compositions including the compounds. The said compounds can be used as antiviral agents and as medicaments for treating diseases such as hepatitis B, influenza, herpes, HIV and so on.

Abstract: The present invention provides small molecule compounds of bisheterocycle in tandem having the structural formula of P1-P2, and the use thereof as well as a composition containing the compounds, each of P1 and P2 is an unsaturated 5-member heterocyclic ring having one or two heteroatoms. This compound may effectively inhibit the replication of influenza virus, the DNA replication of hepatitis B virus (HBV), and the formation of HBsAg and HBeAg. These compounds can be used for the preparation of a medicament for viral diseases, and may overcome the limitations of the known nucleosides drugs, including cytotoxicity, the requirement of other drugs having different structures for against the drug-resistant virus variants induced by long-term therapy. The structure of the compounds according to the invention is relatively simple and easy to be prepared.

Abstract: The invention relates a kind of antiviral agents, more concretely, relates to a kind of heterocyclic non-nucleoside compounds with the following structures, their preparation and pharmaceutical compositions including the compounds. The said compounds can be used as antiviral agents and as medicaments for treating diseases such as hepatitis B, influenza, herpes, HIV and so on.