Patents by Inventor Guihua Lu

Guihua Lu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7078589
    Abstract: The present invention relates to nematode-regulated promoter and polypeptide-encoding nucleotide sequences and their use in creating or enhancing nematode-resistance in plants. Nucleic acid molecules comprising a nematode-resistance sequence operably linked to a nematode-regulated promoter and vectors, plant cells, plants, and transformed seeds containing such constructs are provided. Methods for the use of such constructs in repressing or inducing expression of a nematode-resistance sequence in a plant are also provided. In addition, methods are provided for conferring or improving nematode resistance in plants by repression or induction of nematode-resistance sequences.
    Type: Grant
    Filed: April 30, 2004
    Date of Patent: July 18, 2006
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: Xu Hu, Guihua Lu
  • Patent number: 7041873
    Abstract: The present invention relates to nematode-regulated promoter sequences and their use in creating or enhancing nematode-resistance in plants. Nucleic acid molecules comprising a heterologous nucleotide sequence operably linked to a nematode-regulated promoter and vectors, plant cells, plants, and transformed seeds containing such constructs are provided. Methods for the creation and use of such promoters in repressing or inducing expression of a heterologous nucleotide sequence in a plant, as well as methods for creating or enhancing nematode-resistance in plants by such repression or induction of heterologous nucleotide sequences by nematode-regulated promoters are also provided.
    Type: Grant
    Filed: October 8, 2002
    Date of Patent: May 9, 2006
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: Xu Hu, Guihua Lu, Richard L. Ruff, Wolfgang Schuh
  • Publication number: 20060041955
    Abstract: The invention provides novel molecular genetic markers in soybean, where the markers are useful, for example, in the marker-assisted selection of gene alleles that impart disease-resistance, thereby allowing the identification and selection of a disease-resistant plant. The markers also find use in positional cloning of disease-resistance genes.
    Type: Application
    Filed: August 19, 2005
    Publication date: February 23, 2006
    Applicants: Pioneer Hi-Bred International, Inc., Virginia Tech Intellectual Properties, Inc.
    Inventors: Michael Godwin, Feng Han, Alec Hayes, Xu Hu, Soon-Chun Jeong, Guihua Lu, M. A. Maroof
  • Publication number: 20060041960
    Abstract: This invention relates to an isolated isoflavone synthase 1 (IFS1) promoter nucleic acid fragment. The invention also relates to the construction of chimeric genes comprising all or a portion of the IFS1 promoter directing the expression of transgenes, in sense or antisense orientation.
    Type: Application
    Filed: November 1, 2005
    Publication date: February 23, 2006
    Inventors: Joan Odell, Xiaodan Yu, Guihua Lu, Xu Hu
  • Publication number: 20050102717
    Abstract: Methods and compositions for modulating development and defense responses are provided. Nucleotide sequences encoding maize, soybean, wheat and rice cystatin proteins are provided. The sequences can be used in expression cassettes for modulating development, developmental pathways, and defense responses. Transformed plants, plant cells, tissues, and seed are also provided.
    Type: Application
    Filed: September 23, 2004
    Publication date: May 12, 2005
    Inventors: Daniel Altier, Zhongmeng Bao, Guihua Lu, Pedro Navarro Acevedo, Vincent Sewalt, Carl Simmons, Nasser Yalpani
  • Publication number: 20050070697
    Abstract: The present invention relates to nematode-regulated polypeptides, nucleotide sequences encoding the same and regulatory elements and their use in creating or enhancing pathogen resistance in plants. Nucleic acid constructs comprising a nematode-control sequence operably linked to a promoter, or other nucleotide sequence operably linked to a nematode specific regulatory region are disclosed as well as vectors, plant cells, plants, and transformed seeds containing such constructs are provided. Methods for the use of such constructs in repressing or inducing expression of a nematode-control sequences in a plant are also provided. In addition, methods are provided for conferring or improving pathogen resistance in plants by repression or induction of nematode-control sequences or by spatially and temporally directing expression to pathogen invasion.
    Type: Application
    Filed: September 30, 2003
    Publication date: March 31, 2005
    Inventors: Xu Hu, Guihua Lu
  • Publication number: 20040248304
    Abstract: The present invention relates to nematode-regulated promoter and polypeptide-encoding nucleotide sequences and their use in creating or enhancing nematode-resistance in plants. Nucleic acid molecules comprising a nematode-resistance sequence operably linked to a nematode-regulated promoter and vectors, plant cells, plants, and transformed seeds containing such constructs are provided. Methods for the use of such constructs in repressing or inducing expression of a nematode-resistance sequence in a plant are also provided. In addition, methods are provided for conferring or improving nematode resistance in plants by repression or induction of nematode-resistance sequences.
    Type: Application
    Filed: April 30, 2004
    Publication date: December 9, 2004
    Applicant: Pioneer Hi-Bred International, Inc.
    Inventors: Xu Hu, Guihua Lu
  • Publication number: 20040111761
    Abstract: Compositions and methods to aid in protecting plants from invading pathogenic organisms are provided. The compositions of the invention comprise anti-pathogenic genes, including 5′ regulatory sequences in the promoter, and proteins encoded by the anti-pathogenic genes. The compositions find use in methods for reducing or eliminating damage to plants caused by plant pathogens. Transformed plants, plant cells, tissues, and seed having enhanced disease resistance are also provided.
    Type: Application
    Filed: August 7, 2003
    Publication date: June 10, 2004
    Applicants: Pioneer Hi-Bred International, Inc., CuraGen Corporation
    Inventors: Dennis L. Bidney, Jon Duvick, Xu Hu, Guihua Lu, Oswald R. Crasta
  • Publication number: 20040073971
    Abstract: Compositions and methods to aid in protecting plants from invading pathogenic organisms are provided. The compositions of the invention comprise anti-pathogenic genes, including 5′ regulatory sequences in the promoter, and proteins encoded by the anti-pathogenic genes. The compositions find use in methods for reducing or eliminating damage to plants caused by plant pathogens. Transformed plants, plant cells, tissues, and seed having enhanced disease resistance are also provided.
    Type: Application
    Filed: August 7, 2003
    Publication date: April 15, 2004
    Applicants: Pioneer Hi-Bred International, Inc., CuraGen Corporation
    Inventors: Dennis L. Bidney, Jon Duvick, Xu Hu, Guihua Lu, Oswald R. Crasta
  • Patent number: 6709865
    Abstract: Methods and compositions for modulating development and defense response are provided. Nucleotide sequences encoding a LOX protein are provided. Nucleotide sequences comprising the LOX promoter are also provided. The sequences can be used in expression cassettes for modulating development, developmental pathways, and the plant defense response. Transformed plants, plant cells, tissues, and seed are also provided.
    Type: Grant
    Filed: November 16, 2000
    Date of Patent: March 23, 2004
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: Dennis L. Bidney, Jonathan P. Duvick, Carol Hendrick, Xu Hu, Guihua Lu, Oswald R. Crasta
  • Patent number: 6677503
    Abstract: The invention relates to isolated sunflower nucleic acid sequences encoding a protein having antipathogenic activity, vectors, plant cells, plants and seeds comprising said nucleic acid sequences. The invention further relates to a method of transforming plants for increased resistance against plant pathogens.
    Type: Grant
    Filed: June 8, 2000
    Date of Patent: January 13, 2004
    Assignees: Pioneer Hi-Bred International, Inc., GuraGen Corporation
    Inventors: Dennis L. Bidney, Jon Duvick, Xu Hu, Guihua Lu, Oswald R. Crasta
  • Patent number: 6677502
    Abstract: This invention relates to an isolated nucleic acid fragment encoding a GTP cyclohydrolase II/3,4-dihydroxy-2-butanone-4-phosphate synthase protein. The invention also relates to the construction of a chimeric gene encoding all or a substantial portion of the protein, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of the protein in a transformed host cell.
    Type: Grant
    Filed: July 12, 2000
    Date of Patent: January 13, 2004
    Assignees: E.I. du Pont de Nemours and Company, Pioneer Hi-Bred International
    Inventors: Stephen M. Allen, Anthony J. Kinney, J. Antoni Rafalski, Emil M. Orozco, Jr., Guo-Hua Miao, Omolayo O. Famodu, Jian-Ming Lee, Karin N. Lohman, Alan R. Rendina, Hajime Sakai, Zude Weng, Perry G. Caimi, Yiwen Fang, Jennie Bih-Jien Shen, Ilham L. Zoughi, Shawn L. Anderson, Jinrui Shi, Guihua Lu, Timothy G. Helentjaris, Chun Ping Li
  • Patent number: 6667427
    Abstract: Compositions and methods to aid in protecting plants from invading pathogenic organisms are provided. The compositions of the invention comprise anti-pathogenic nucleotide sequences, including their promoters, and polypeptides encoded by the anti-pathogenic nucleic acid sequences. The compositions find use in methods for reducing or eliminating damage to plants caused by plant pathogens. Transformed plants, plant cells, tissues, and seed are also provided having enhanced disease resistance.
    Type: Grant
    Filed: October 10, 2000
    Date of Patent: December 23, 2003
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: Zhangmeng Bao, Jonathan P. Duvick, Xu Hu, Guihua Lu
  • Patent number: 6660907
    Abstract: Compositions and methods for enhancing the resistance of plants to pests and for altering the level of biotin in plants are provided. Nucleotide sequences isolated from soybean, rice, maize, and wheat are provided. The nucleotide sequences encode orthologs of sunflower SCIP-1. Also provided are the SCIP-1 proteins encoded by such nucleotide sequences. The methods involve transforming plants with the SCIP-1 nucleotide sequences to enhance the plant's resistance to plant pests or to alter the level of biotin in the plant. Transformed plants, plant cells, tissues, and seeds are also provided.
    Type: Grant
    Filed: July 10, 2001
    Date of Patent: December 9, 2003
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: Carol A. Hendrick, Xu Hu, Guihua Lu
  • Patent number: 6630615
    Abstract: The invention relates to the genetic manipulation of plants, particularly to the expression of nucleotide sequences from defense-related signaling genes. Isolated nucleotide sequences encoding a neoxanthin cleavage enzyme, an amino acid permease, and a novel protein are provided. Also provided are isolated nucleotide sequences comprising promoters that drive expression in a plant in an inducible or tissue-preferred manner. The nucleotide sequences find use in increasing the resistance of plants to pathogens and other stresses, modifying ABA metabolism in plants, modifying amino acid transport and content in plants, and regulating gene expression in plants. Additionally provided are isolated proteins, and transformed plants and seeds thereof.
    Type: Grant
    Filed: August 17, 2000
    Date of Patent: October 7, 2003
    Assignees: Pioneer Hi-Bred International, Inc., Curagen Corporation
    Inventors: Dennis L. Bidney, Oswald R. Crasta, Xu Hu, Guihua Lu
  • Publication number: 20030167507
    Abstract: This invention relates to an isolated isoflavone synthase 1 (IFS1) promoter nucleic acid fragment. The invention also relates to the construction of chimeric genes comprising all or a portion of the IFS1 promoter directing the expression of transgenes, in sense or antisense orientation.
    Type: Application
    Filed: March 22, 2002
    Publication date: September 4, 2003
    Inventors: Joan T. Odell, Xiaodan Yu, Guihua Lu, Xu Hu
  • Patent number: 6608240
    Abstract: Compositions and methods for enhancing disease resistance in plants are provided. Compositions comprise sunflower resistance gene analogs. The methods involve transforming a plant with a resistance nucleotide sequence. The methods find use in enhancing broad-based resistance in plants to pathogens. Also provided are transformed plants, plant cells, tissues, and seeds having enhanced disease resistance. The R gene analogs can be used as molecular markers for disease resistance.
    Type: Grant
    Filed: June 23, 2000
    Date of Patent: August 19, 2003
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: Dennis L. Bidney, Xu Hu, Guihua Lu
  • Publication number: 20030119165
    Abstract: This invention relates to an isolated nucleic acid fragment encoding a transcription factor. The invention also relates to the construction of a chimeric gene encoding all or a portion of the transcription factor, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of the transcription factor in a transformed host cell.
    Type: Application
    Filed: November 21, 2002
    Publication date: June 26, 2003
    Inventors: Rebecca E. Cahoon, Guihua Lu, Mark E. Williams
  • Publication number: 20030101483
    Abstract: The present invention relates to nematode-regulated promoter sequences and their use in creating or enhancing nematode-resistance in plants. Nucleic acid molecules comprising a heterologous nucleotide sequence operably linked to a nematode-regulated promoter and vectors, plant cells, plants, and transformed seeds containing such constructs are provided. Methods for the creation and use of such promoters in repressing or inducing expression of a heterologous nucleotide sequence in a plant, as well as methods for creating or enhancing nematode-resistance in plants by such repression or induction of heterologous nucleotide sequences by nematode-regulated promoters are also provided.
    Type: Application
    Filed: October 8, 2002
    Publication date: May 29, 2003
    Applicant: Pioneer Hi-Bred International, Inc.
    Inventors: Xu Hu, Guihua Lu, Richard L. Ruff, Wolfgang Schuh
  • Patent number: 6555673
    Abstract: Synthetic elements for enhancing expression of genes in plant cells are disclosed. These include a promoter with a “TATA to start” sequence containing 64% or greater GC content and an synthetic upstream element incorporating several OCS binding motifs and novel flanking sequences. Upstream activating regions (UARs) are also disclosed that can further increase the constitutive transcriptional activity when they are operably linked to said promoter and/or the synthetic upstream element. In particular, the nucleotide sequence of the UAR of the maize Ubi-1 gene is provided and its use in expression cassettes and vectors containing these promoter elements. Cells and plants transformed with these vectors are further provided. These include a transgenic sunflower expressing an exogenous oxalate oxidase gene at a high level under the transcriptional control of a recombinant promoter having at least one upstream activating region of the 35S CaMV promoter.
    Type: Grant
    Filed: April 21, 2000
    Date of Patent: April 29, 2003
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: Benjamin A. Bowen, Wesley B. Bruce, Guihua Lu, Lynne E. Sims, Laura A. Tagliani