Abstract: The present disclosure discloses an optical imaging system including, sequentially from an object side to an image side along an optical axis, a first lens, a second lens, a third lens, a fourth lens, a fifth lens, a sixth lens and a seventh lens, each of which has refractive power. An object-side surface of the first lens is concave, and an image-side surface thereof is convex; the sixth lens has a positive refractive power; and the seventh lens has a negative refractive power, and an object-side surface thereof is convex. Half of a diagonal length ImgH of an effective pixel area on an imaging plane of the optical imaging system satisfies 6 mm<ImgH<7 mm; and a total effective focal length f of the optical imaging system and an effective focal length f6 of the sixth lens satisfy 0.22?f/f6<1.

Abstract: The present invention relates to the field of genetic engineering, and provides a zipper fastener structure of promoting formation of a protein dimer and application thereof. The zipper fastener can be applied to dimerization of proteins of the same type and dimerization of proteins of different types, and can also be applied to polypeptide cycle formation, polypeptide dimerization, and polypeptide extension. A ESAT6-CFP 10 dimer having an approximately native conformation can be obtained, and the dimer has better solubility, and has a better stimulating effect on memory T cells than a ESAT6-CFP10 fusion protein capable of linear fusion expression. A dimer zipper fastener can assist the formation of a more stable cyclic polypeptide, and a CCP polypeptide added with a dimer fastener can improve the detection rate for citrullinated autoantibodies in serum of a rheumatoid arthritis patient.

Abstract: The present disclosure discloses an optical imaging system including, sequentially from an object side to an image side along an optical axis, a first lens, a second lens, a third lens, a fourth lens, a fifth lens, a sixth lens and a seventh lens, each of which has refractive power. An object-side surface of the first lens is concave, and an image-side surface thereof is convex; the sixth lens has a positive refractive power; and the seventh lens has a negative refractive power, and an object-side surface thereof is convex. Half of a diagonal length ImgH of an effective pixel area on an imaging plane of the optical imaging system satisfies 6 mm<ImgH<7 mm; and a total effective focal length f of the optical imaging system and an effective focal length f6 of the sixth lens satisfy 0.22?f/f6<1.