Abstract: A device which includes a generator of electric current pulses and a neurostimulation probe with M sectoral electrodes forming stimulation poles for passing a current between at least one anode and at least one cathode in a predetermined stimulation configuration. The generator includes N current sources and N current sinks, the N sources and the N sinks being defined independently of the M electrodes. A first distribution circuit can indiscriminately and dynamically switch any of the N sources to any of the M electrodes, and a second distribution circuit can indiscriminately and dynamically switch any of the N sinks to any of the M electrodes. The device can thus define a plurality of commutation combinations between sources and/or sinks, providing a single average current in the organ to be stimulated for different respective predetermined pole configurations.

Abstract: The invention relates to a device which includes a generator of electric current pulses and a neurostimulation probe with M sectoral electrodes forming stimulation poles for passing a current between at least one anode and at least one cathode in a predetermined stimulation configuration. The generator includes N current sources and N current sinks, the N sources and the N sinks being defined independently of the M electrodes. A first distribution circuit can indiscriminately and dynamically switch any of the N sources to any of the M electrodes, and a second distribution circuit can indiscriminately and dynamically switch any of the N sinks to any of the M electrodes. The device can thus define a plurality of commutation combinations between sources and/or sinks, providing a single average current in the organ to be stimulated for different respective predetermined pole configurations.

Abstract: On a channel of an implantable cardiac generator, a cardiac lead is replaced by a vagus nerve stimulation VNS lead. The control circuit controlling the stimulation circuit of this channel of the generator is configured to generate sequences of VNS neurostimulation bursts according to a specific profile, synchronized or not with the heart rate. The control circuit dynamically controls the initial load voltage of the reservoir capacitor so as to adjust to a constant target value the electrical charge delivered to the nerve by each stimulating pulse, from a pulse to the next one and from a burst to the next one. This improves the consistency of the physiological effects of neurostimulation despite significant variations that may occur in impedance at the electrode/vagus nerve interface.

Abstract: On a channel of an implantable cardiac generator, a cardiac lead is replaced by a vagus nerve stimulation VNS lead. The control circuit controlling the stimulation circuit of this channel of the generator is configured to generate sequences of VNS neurostimulation bursts according to a specific profile, synchronized or not with the heart rate. The control circuit dynamically controls the initial load voltage of the reservoir capacitor so as to adjust to a constant target value the electrical charge delivered to the nerve by each stimulating pulse, from a pulse to the next one and from a burst to the next one. This improves the consistency of the physiological effects of neurostimulation despite significant variations that may occur in impedance at the electrode/vagus nerve interface.