Abstract: The present disclosure describes processes and intermediates useful for preparing a compound of Formula (Xa) or Formula (Xb). The processes and intermediates can be used to prepare the compounds of the disclosure at multigram or kilogram scale.

Abstract: The present disclosure is directed to compounds that are inhibitors of HIF-2? having a structure according to Formula I, and compositions containing those compounds. Methods of using the compounds for the treatment of diseases, disorders, or conditions are also described.

Abstract: Methods and systems are configured for monitoring operations of a computing device by associating threads executing in a user space with kernel events in a kernel space. The systems and methods are configured for detecting a kernel event in the kernel space of the computing device; in response to detecting the kernel event, accessing, from a mapping table that maps a computing thread in the user space to a span that is active on the computing thread, a base address of a memory in the user space of the computing device, the memory storing a span identifier for each span in the user space, the span comprising one or more operations of a computing thread that is active in the user space; accessing, based on the base address, a span identifier in the memory; and associating the span identifier with the kernel event.

Abstract: Problems of thermal resistance of the anode of an x-ray tube are solved by constructing a flat cathode which is set within a stair-step focusing device. It is shown that, depending on the shape of this device, the heat output on the anode is limited by a saturation value which is lower than a limit of thermal resistance of the x-ray tube. In order to improve the thermal resistance of the cathode, a cathode is constructed in the form of a hollow beam. This ensures rigidity of the cathode which is inherent in its beam shape without being attended by the disadvantages of excessive thermal inertia.