Abstract: The invention relates to an in vitro method for detecting or monitoring an endometrial or ovarian carcinoma in a human subject, which method comprises detecting, or determining the level of, methylation of OXT and/or ZSCAN12 gene in a biological sample from the subject.

Abstract: A filter device for a fume extraction device includes at least two filter elements arranged at an angle relative to one another, and a holding frame for holding the at least two filter elements. An edge of one of the at least two filter elements lies adjacent to an edge of the other one of the at least two filter element. Each of the at least two filter elements has a surface with a variable distance between opposite outer faces of the filter element.

Abstract: This invention relates to compounds of formula (I) and salts, solvates, tautomers, N-oxides, stereoisomers, polymorphs and/or prodrugs thereof. Also disclosed is the use of the compound of formula (I) to treat necroptosis and/or inhibit RIP1 and/or MLKL.

Abstract: This invention relates to compounds of formula (I) and salts, solvates, tautomers, N-oxides, stereoisomers, polymorphs and/or prodrugs thereof. Also disclosed is the use of the compounds of formula (I) to treat necroptosis and/or inhibit MLKL.

Abstract: A cooking-appliance system includes a cooktop having a cooktop panel with an extractor aperture for suction extraction of vapors which are produced in an operating state. An extractor unit is provided for suction extraction of the vapors through the extractor aperture; and an oven is arranged beneath the cooktop in an installation position.

Abstract: A combination appliance includes a hob including a cooking module and having a suction opening, and a fume extraction device located, at least in part, below the cooking module. The fume extraction device includes a blower located below the suction opening and having an air inlet opening, and a filter unit located at the suction opening and having a grease filter. The fume extraction device includes a separating plate which separates the filter unit from the blower located below the filter unit.

Abstract: A filter device for a vapor extraction device includes a grease filter, and a collecting container for collecting liquid. The collecting container includes an opening configured to receive at least part of an edge of the grease filter. The collecting container has an interior defined by a width which is greater than a thickness of the grease filter in a region in which the grease filter is located in the interior of the collecting container.

Abstract: A fume extractor device for a hob includes an air intake opening via which air is sucked downward, and a fan which includes a fan housing, a fan wheel received in the fan housing, and a motor received in the fan housing and operably connected to the fan wheel The fan housing has an upper face which includes an air inlet opening. Means for removing impurities in the fume extractor device are provided only in a flow direction downstream of the air inlet opening of the fan housing.

Abstract: A filter device for a fume extraction device includes at least two filter elements arranged at an angle relative to one another, and a holding frame for holding the at least two filter elements. An edge of one of the at least two filter elements lies adjacent to an edge of the other one of the at least two filter element. Each of the at least two filter elements has a surface with a variable distance between opposite outer faces of the filter element.

Abstract: The invention relates to novel heterocyclic compounds of Formula (I) which inhibit necroptosis and methods for their use. The compounds may be useful in the treatment of conditions associated with deregulated necroptosis.

Abstract: The present invention relates to methods for inhibiting necroptosis; screening methods for identifying compounds which inhibit necroptosis; and compounds for the inhibition of necroptosis, which may be useful in the treatment of conditions associated with deregulated necroptosis.

Abstract: In one aspect, the present invention provides for a compound of Formula I in which in Formula I, the variables X1, X2a, X2b, X2c, R1, B, L, E, A and the subscript n are as defined herein. In another aspect, the present invention provides for pharmaceutical compositions comprising compounds of Formula I as well as methods for using compounds of Formula I for the treatment of diseases and conditions (e.g., cancer, thrombocythemia, etc) characterized by the expression or over-expression of Bcl-2 anti-apoptotic proteins, e.g., of anti-apoptotic Bcl-xL proteins.

Abstract: The present invention relates to chemical compounds of formula (I) and methods for their use and preparation. In particular, the invention relates to substituted pyrazolo[3,4-d]pyrimidine based compounds which can be used in treating proliferative disorders, use of these compounds in methods of therapy and the manufacture of medicaments as well as compositions containing these compounds.

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

Abstract: In one aspect, the present invention provides for a compound of Formula I in which in Formula I, the variables X1, X2a, X2b, X2c, R1, B, L, E, A and the subscript n are as defined herein. In another aspect, the present invention provides for pharmaceutical compositions comprising compounds of Formula I as well as methods for using compounds of Formula I for the treatment of diseases and conditions (e.g., cancer, thrombocythemia, etc) characterized by the expression or over-expression of Bcl-2 anti-apoptotic proteins, e.g., of anti-apoptotic Bcl-xL proteins.

Abstract: In one aspect, the present invention provides for a compound of Formula I in which in Formula I, the variables X1, X2a, X2b, X2c, R1, B, L, E, A and the subscript n are as defined herein. In another aspect, the present invention provides for pharmaceutical compositions comprising compounds of Formula I as well as methods for using compounds of Formula I for the treatment of diseases and conditions (e.g., cancer, thrombocythemia, etc) characterized by the expression or over-expression of Bcl-2 anti-apoptotic proteins, e.g., of anti-apoptotic Bcl-xL proteins.

Abstract: The present invention relates to chemical compounds of formula (I) and methods for their use and preparation. In particular, the invention relates to substituted pyrazolo[3,4-d]pyrimidine based compounds which can be used in treating proliferative disorders, use of these compounds in methods of therapy and the manufacture of medicaments as well as compositions containing these compounds.

Abstract: In one aspect, the present invention provides for a compound of Formula I in which the variable X1a, X1b, X1c, X1d, Q, A, R1, B, L, E, and the subscripts m and n have the meanings as described herein. In another aspect, the present invention provides for pharmaceutical compositions comprising compounds of Formula I as well as methods for using compounds of Formula I for the treatment of diseases and conditions (e.g., cancer, thrombocythemia, etc) characterized by the expression or over-expression of Bcl-2 anti-apoptotic proteins, e.g., of anti-apoptotic Bcl-xL proteins.

Abstract: In one aspect, the present invention provides for a compound of Formula I in which in Formula I, the variables X1, X2a, X2b, X2c, R1, B, L, E, A and the subscript n are as defined herein. In another aspect, the present invention provides for pharmaceutical compositions comprising compounds of Formula I as well as methods for using compounds of Formula I for the treatment of diseases and conditions (e.g., cancer, thrombocythemia, etc) characterized by the expression or over-expression of Bcl-2 anti-apoptotic proteins, e.g., of anti-apoptotic Bcl-xL proteins.