Patents by Inventor Guillaume Le

Guillaume Le has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel derivatives of 3-imino-1,2-dithioles, method for producing them and pharmaceutical compositions containing the same
    Publication number: 20030013742
    Abstract: Compound of formula (I): 1
    Type: Application
    Filed: June 21, 2002
    Publication date: January 16, 2003
    Inventors: Muriel Duflos, Jean-Michel Robert, Marie-Renee Nourrisson, Guillaume Le Baut, Daniel-Henri Caignard, Jean-Guy Bizot-Espiard, Pierre Renard
  • Substituted N-benzylindol-3-ylglyoxylic acid derivatives having antitumor action
    Patent number: 6432987
    Abstract: The invention relates to novel, substituted N-benzyl-indol-3-ylglyoxylic acid derivatives of the following formula and their use for the treatment of oncoses The invention further relates to their physiologically tolerable acid addition salts and if possible their N-oxides.
    Type: Grant
    Filed: December 15, 2000
    Date of Patent: August 13, 2002
    Assignee: Zentaris AG
    Inventors: Eckhard Gunther, Peter Emig, Dietmar Reichert, Guillaume Le Baut, Bernd Nickel, Gerald Bacher
  • Substituted N-benzylindol-3-ylglyoxylic acid derivatives having antitumor action
    Publication number: 20010014690
    Abstract: The invention relates to novel, substituted N-benzyl-indol-3-ylglyoxylic acid derivatives of the following formula and their use for the treatment of oncoses 1
    Type: Application
    Filed: December 15, 2000
    Publication date: August 16, 2001
    Inventors: Eckhard Gunter, Peter Emig, Dietmar Reichert, Guillaume Le Baut, Bernd Nickel, Gerald Bacher
  • Benzopyran compounds
    Patent number: 5889045
    Abstract: A compound of formula (I): ##STR1## in which: R.sub.1 represents alkyl,R.sub.2, R.sub.4 and R.sub.5, which may be identical or different, represent hydrogen or alkyl,R.sub.3 represents any one of the groups as defined in the description,X represents carbonyl or methylene,Y represents hydrogen or alkyl or aryl,A represents single bond or alkylphenyl,R.sub.6 represents any one of the groups as defined in the description, its isomers as well as its addition salts with a pharmaceutically acceptable acid or base,and medicinal productes containing the same are useful in the treatment of diabetes and complications of diabetic disease.
    Type: Grant
    Filed: November 25, 1997
    Date of Patent: March 30, 1999
    Assignee: Adir et Compagnie
    Inventors: Timothee Muller, Claudie Moulin, Muriel Duflos, Sylvie Robert-Piessard, Guillaume Le Baut, Alain Tonnerre, Daniel-Henri Caignard, Dominique Manechez, Pierre Renard
  • N-pyridyl carboxamides and derivatives
    Patent number: 5843947
    Abstract: A compound selected from those of formula (I): ##STR1## where m is equal to 0 or 1 and Het, A, X, R,R.sub.1, R.sub.2, R.sub.3, R.sub.4 and the ring ##STR2## are defined in the description, and a medicinal product comprising the same for treating an inflammatory disorder.
    Type: Grant
    Filed: March 26, 1997
    Date of Patent: December 1, 1998
    Assignee: Adir et Compagnie
    Inventors: Jean-Michel Robert, Odile Rideau, Sylvie Robert-Piessard, Jacqueline Courant, Guillaume Le Baut, Daniel-Henri Caignard, Pierre Renard, Gerard Adam
  • N-pyridyl carboxamides and derivatives
    Patent number: 5712294
    Abstract: A compound selected from those of formula (I): ##STR1## where m is equal to 0 or 1andHet, A, X, R, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and the ring ##STR2## are defined in the description, and a medicinal product comprising the same for treating an inflammatory disorder.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: January 27, 1998
    Assignee: Adir Et Compagnie
    Inventors: Jean-Michel Robert, Odile Rideau, Sylvie Robert-Piessard, Jacqueline Courant, Guillaume Le Baut, Daniel-Henri Caignard, Pierre Renard, Gerard Adam
  • Use of benzopyran derivatives for the treatment of pathologies associated with the NA.sup.+ -independent CI-/HCO.sub.3 -exchanger
    Patent number: 5703118
    Abstract: A method of treating a mammal afflicted with a disorder associated with the Na.sup.+ -independent Cl.sup.- /HCO.sub.3 - exchanger comprising the step of administering a compound selected from those of formula (I): ##STR1## in which R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9, R.sub.10, R.sub.11 and n are as defined in the description, which is effective for alleviating the said disorder.
    Type: Grant
    Filed: May 3, 1996
    Date of Patent: December 30, 1997
    Assignee: Adir et Compagnie
    Inventors: Ludovic Durand, Jean-Paul Babingui, Claudie Moulin, Sylvie Robert-Piessard, Guillaume Le Baut, Elisabeth Scalbert, Daniel-Henri Caignard, Pierre Renard
  • Alpha-amino acid compounds
    Patent number: 5585390
    Abstract: Compounds of the general formula: ##STR1## wherein m, X, Y, A, R.sub.2 and R.sub.3 are defined in the description, and medicaments containing the same.
    Type: Grant
    Filed: May 9, 1995
    Date of Patent: December 17, 1996
    Assignee: Adir Et Compagnie
    Inventors: Muriel Duflos, Sylvie Robert-Piessard, Lucien Welin, Guillaume Le Baut, Daniel-Henri Caignard, Pierre Renard, G erard Adam
  • .alpha.-amino acid compounds
    Patent number: 5470864
    Abstract: Compounds of the general formula: ##STR1## wherein m, X, Y, A, R.sub.2 and R.sub.3 are defined in the description.
    Type: Grant
    Filed: June 30, 1994
    Date of Patent: November 28, 1995
    Assignee: Adir et Compagnie
    Inventors: Muriel Duflos, Sylvie Robert-Piessard, Lucien Welin, Guillaume Le Baut, Daniel-Henri Caignard, Pierre Renard, Gerard Adam
  • Heterocyclic compounds: 2-styryl-4H-1-benzopyran-4-ones
    Patent number: 5409952
    Abstract: A compound of the formula (I) ##STR1## in which: R.sub.1 represents a hydrogen atom, a lower alkyl group, a hydroxy group or a lower alkoxy group,R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8 and R.sub.11 are as defined in the description.Medicaments.
    Type: Grant
    Filed: October 27, 1993
    Date of Patent: April 25, 1995
    Assignee: Adir et Compagnie
    Inventors: Jean D. Brion, Guillaume Le Baut, Francoise Zammatio, Alain Pierre, Ghanem Atassi, Larbi Belachmi
  • New benzopyran compounds
    Patent number: 5395834
    Abstract: A compound selected from those of formula (I): ##STR1## in which R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9 and n are as defined in the description, its optical isomers, and its addition salts thereof with a pharmaceutically-acceptable acid or base, and medicinal product containing the same for treating a mammal afflicted with a disorder connected with peroxydation processes and biosynthesis of eicosanoids.
    Type: Grant
    Filed: April 11, 1994
    Date of Patent: March 7, 1995
    Assignee: Adir et Compagnie
    Inventors: Guillaume Le Baut, Jean-Paul Babingui, Sylvie Robert-Piessard, Pierre Renard, Daniel-Henri Caignard, Jean-Francois Renaud de la Faverie, Gerard Adam
  • Benzopyran compounds
    Patent number: 5393775
    Abstract: A compound selected from those of formula (I): ##STR1## in which R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9 and n are as defined in the description, its optical isomers, and its addition salts thereof with a pharmaceutically-acceptable acid or base,and medicinal product containing the same for treating a mammal afflicted with a disorder connected with peroxydation processes and biosynthesis of eicosanoids.
    Type: Grant
    Filed: September 7, 1993
    Date of Patent: February 28, 1995
    Assignee: Adir et Compagnie
    Inventors: Guillaume Le Baut, Jean-Paul Babingui, Sylvie Robert-Piessard, Pierre Renard, Daniel-henri Caignard, jean-Francois Renaud de la Faverle, Gerard Adam
  • New chromene compounds having a triene side chain
    Patent number: 5391569
    Abstract: A compound selected from those of formula (I): ##STR1## in which the groups R.sub.1 to R.sub.8 are as defined the description. Medicaments.
    Type: Grant
    Filed: September 28, 1993
    Date of Patent: February 21, 1995
    Assignee: Adir et Compagnie
    Inventors: Jean-Daniel Brion, Guillaume Le Baut, Guillaume Poissonnet, Lucy De Montarby, Larbi Belachmi, Jacqueline Bonnet, Massimo Sabatini, Charles Tordjman
  • New 3-(hydroxybenzylidenyl)-indolin-2-ones
    Patent number: 5382593
    Abstract: The invention relates to a compound selected from those of formula (I): ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and X are as defined in the description, its Z and E isomers, its optical isomers, in pure form or in the form of a mixture, and its addition salts thereof with a pharmaceutically-acceptable acid or base, and medicinal products containing the same which are useful in treating a disorder resulting from or associated with peroxidation phenomena, disturbances in eicosanoid synthesis, or with platelet aggregation disorders.
    Type: Grant
    Filed: July 20, 1993
    Date of Patent: January 17, 1995
    Assignee: Adir et Compagnie
    Inventors: Guillaume Le Baut, Marie-Renee Nourrisson, Jean-Francois Renaud de la Faverie, Jean-Guy Bizot Espiard, Daniel-Henri Caignard, Pierre Renard, Gerard Adam
  • Benzopyran compounds
    Patent number: 5315017
    Abstract: A compound selected from the group consisting of those of formula I ##STR1## in which R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, X and n are defined in the description, an optical isomer thereof, and an addition salt thereof with a pharmaceutically-acceptable base or acid.Medicinal product which is useful in treating or in preventing a disorder due to or linked to the phenomena of peroxidation and to the disturbance of the eicosanoid biosynthesis.
    Type: Grant
    Filed: May 1, 1992
    Date of Patent: May 24, 1994
    Assignee: Adir Et Compagnie
    Inventors: Guillaume Le Baut, Jean-Paul Babingui, Jacqueline Courant, Jean-Michel Robert, Pierre Renard, Daniel-Henri Caignard, Jean-Francois R. de la Faverie, Gerard Adam
  • Benzopyran compounds
    Patent number: 5290797
    Abstract: A compound selected from those of the formula I: ##STR1## in which: R.sub.1 represents hydrogen or alkyl having 1 to 3 inclusive carbon atoms,R represents hydrogen, alkyl having 1 to 4 inclusive carbon atoms, or acyl --CO--R' in which R' represents alkyl having 1 to 4 inclusive carbon atoms,X represents O or H.sub.2,an isomer,and an addition salt thereof with a pharmaceutically-acceptable acid or base, andmedicinal products containing the same which are useful in treating or in preventing disorder resulting from or associated with phenomena of peroxidation and disturbance of the synthesis of eicosanoids.
    Type: Grant
    Filed: March 4, 1992
    Date of Patent: March 1, 1994
    Assignee: Adir et Compagnie
    Inventors: Guillaume Le Baut, Jean-Paul Babingui, Jean-Michel Robert, Pierre Renard, Jean-Francois Renaud de la Faverie, Gerard Adam
  • New heteroarotinoid compounds
    Patent number: 4975455
    Abstract: Compounds of general formula (I): ##STR1## in which: R denotes a hydrogen atom, a halogen atom or a hydroxy, lower alkyl, lower alkyloxy, carboxyl, (lower alkyloxy)carbonyl, (lower arylalkyloxy)carbonyl, aminocarbonyl, (lower mono- or dialkyl)aminocarbonyl or (lower arylalkyl)aminocarbonyl group, an aminocarbonyl group N-substituted with a heterocyclic radical, or a thio, (lower alkyl)thio, sulfonyl or (lower alkyl)sulfonyl group,R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which may be identical or different, denote a hydrogen atom, a halogen atom or a lower alkyl, lower alkenyl, lower alkyloxy or lower alkenyloxy group, optionally substituted with one or more halogen atoms,their isomers, enantiomers, diastereoisomers and also, when R denotes a carboxyl, their addition salts with a pharmaceutically acceptable base and, when R contains a basic group, their addition salts with a pharmaceutically acceptable acid.
    Type: Grant
    Filed: April 11, 1989
    Date of Patent: December 4, 1990
    Assignee: Adir et Cie
    Inventors: Jean-Daniel Brion, Guillaume Le Baut, Patrick Ducrey, Sylvie Piessard-Robert, Claude Cudennec, Genevieve Seurre
  • Triene compounds having a chromene structure
    Patent number: 4975454
    Abstract: Compounds of general formula (I): ##STR1## in which: R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which may be identical or different, denote a hydrogen atom, a halogen atom or a lower alkyl, lower alkenyl, lower alkyloxy or lower alkenyloxy group, optionally substituted with one or more halogen atoms,R.sub.5 denotes a carboxyl, (lower alkyloxy)carbonyl, (lower alkenyloxy)carbonyl or (lower alkynyloxy)-carbonyl,their isomers, stereoisomers and diastereoisomers, and also their addition salts with a pharmaceutically acceptable base.Medicinal products.
    Type: Grant
    Filed: April 11, 1989
    Date of Patent: December 4, 1990
    Assignee: Adir et Compagnie
    Inventors: Jean-Daniel Brion, Guillaume Le Baut, Patrick Ducrey, Sylvie Piessard-Robert, Claude Cudennec, Genevieve Seurre
  • N-substituted 2-aminomethylene-1,3-indanediones for treating arterial hypertension and spasmodic conditions
    Patent number: 4758561
    Abstract: The present invention to pharmaceutical composition comprising an effective amount of products having the structural formula ##STR1## where R.sub.1 is a hydrogen atom or a lower alkyl group such as methyl or ethyl,R.sub.2 is a straight or branched cyclopropylmethyl, 2-furyl methyl, benzyl, phenyl or lower alkyl group from C.sub.1 to C.sub.4 such as methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tertiary butyl; the NR.sub.1 R.sub.2 group can also represent a nitrogenous heterocyclic compound N(CH.sub.2).sub.n in which n can be any value between 4 and 6.The products are useful in human and veterinary therapy because of their anti-inflammatory, diuretic, bronchodilating, anticholinergic, antispasmodic and antidepressant properties.
    Type: Grant
    Filed: July 22, 1985
    Date of Patent: July 19, 1988
    Assignee: Societe Cortial, S.A.
    Inventors: Guillaume Le Baut, Louis Sparfel, Marie-Helene Creuzet, Claude Feniou, Henri Pontagnier, Gisele Prat
  • Therapeutic application of N-substituted 2-aminomethylene-1,3-indanediones
    Patent number: 4757067
    Abstract: The present invention to pharmaceutical composition comprising an effective amount of products having the structural formula ##STR1## where R.sub.1 is a hydrogen atom or a lower alkyl group such as methyl or ethyl,R.sub.2 is a straight or branched cyclopropylmethyl, 2-furyl methyl, benzyl, phenyl or lower alkyl group from C.sub.1 to C.sub.4 such as methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tertiary butyl; the NR.sub.1 R.sub.2 group can also represent a nitrogenous heterocyclic compound N(CH.sub.2).sub.n in which n can be any value between 4 and 6.The products are useful in human and veterinary therapy because of their anti-inflammatory, diuretic, bronchodilating, anticholinergic, antispasmodic and antidepressant properties.
    Type: Grant
    Filed: January 21, 1987
    Date of Patent: July 12, 1988
    Assignee: Societe Cortial, S.A.
    Inventors: Guillaume Le Baut, Louis Sparfel, Marie-Helene Creuzet, Claude Feniou, Henri Pontagnier, Gisele Prat